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When Does Deletion Of 11q22.3 In B Cells Occur During Chronic Lymphocytic Leukemia?
Question: meanig of having Deletion of 11q22.3: 48% (48/100) of cells; with CLL
Brief Answer:
It is chromosomal abnormality seen in B cell CLL.
Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.
Deletion of 11q22.3 is chromosomal abnormality seen in b cell Chronic lymphocytic leukemia.
It mean there is loss of some chromosomal material on long arm of chromosome 11. Mostly it involves ATM gene. 48% cells show this abnormality.
It has prognostic significance.
It is associated with large and bulky lymphadenopathy and poor prognosis. So mainly it has prognostic significance and associated with poor outcome and high chance of disease progression.
Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.
It is chromosomal abnormality seen in B cell CLL.
Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.
Deletion of 11q22.3 is chromosomal abnormality seen in b cell Chronic lymphocytic leukemia.
It mean there is loss of some chromosomal material on long arm of chromosome 11. Mostly it involves ATM gene. 48% cells show this abnormality.
It has prognostic significance.
It is associated with large and bulky lymphadenopathy and poor prognosis. So mainly it has prognostic significance and associated with poor outcome and high chance of disease progression.
Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Is their any hope or treatment for this condition ,or is this the end of the line for me
Brief Answer:
Treatment is chemotherapy or monoclonal antibody.
Detailed Answer:
Hi dear
I have gone through your question. I can understand your concern.
Treatment is based on the severity of associated symptoms as well as the rate of cancer growth. There are many factors like stage of disease, symptoms, overall health, benefits verses side effects affect the treatment decision.
You should start treatment of your CLL. Because you have high chance of disease progression.
There are many options available.
Chemotherapy, monoclonal antibodies treatment, targeted therapy or biological therapy are useful.
Consult your doctor and start suitable regimen for you.
Don't worry much about that. Just be relaxed. It is not the end of line. There is a hope. And hope for the best.
Hope I have answered your question. If you have any doubts then feel free to ask me. I will be happy to answer. thanks for using health care magic. Wish you a very good health.
Treatment is chemotherapy or monoclonal antibody.
Detailed Answer:
Hi dear
I have gone through your question. I can understand your concern.
Treatment is based on the severity of associated symptoms as well as the rate of cancer growth. There are many factors like stage of disease, symptoms, overall health, benefits verses side effects affect the treatment decision.
You should start treatment of your CLL. Because you have high chance of disease progression.
There are many options available.
Chemotherapy, monoclonal antibodies treatment, targeted therapy or biological therapy are useful.
Consult your doctor and start suitable regimen for you.
Don't worry much about that. Just be relaxed. It is not the end of line. There is a hope. And hope for the best.
Hope I have answered your question. If you have any doubts then feel free to ask me. I will be happy to answer. thanks for using health care magic. Wish you a very good health.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Brief Answer:
You can wait.
Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.
whether treatment should be taken or not depends on symptoms and stage of disease.
If you don't have any symptoms then nothing to worry. Its not necessary to start treatment right now. You can wait for a while.
Wait and watch approach is commonnly used in early stage of CLL. But you should go for regular follow up. Start treatment later on when needed.
Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.
You can wait.
Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.
whether treatment should be taken or not depends on symptoms and stage of disease.
If you don't have any symptoms then nothing to worry. Its not necessary to start treatment right now. You can wait for a while.
Wait and watch approach is commonnly used in early stage of CLL. But you should go for regular follow up. Start treatment later on when needed.
Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
I am 70 now . Do I have any chance of living 5 to 10 more years
Brief Answer:
Overall 5 year survival rate is 60 to 80%.
Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.
Prognosis and survival rate depends on many factors like stage, type, genetic abnormality, number of abnormal lymphocytes, patients co morbid condition, other medical history and many others.
It is not possible to tell a person how long he will live with CLL.
But from statistics we can say that approximately 5 year survival rate is 60 to 80%.
Don't worry much about that.
Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.
Overall 5 year survival rate is 60 to 80%.
Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.
Prognosis and survival rate depends on many factors like stage, type, genetic abnormality, number of abnormal lymphocytes, patients co morbid condition, other medical history and many others.
It is not possible to tell a person how long he will live with CLL.
But from statistics we can say that approximately 5 year survival rate is 60 to 80%.
Don't worry much about that.
Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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