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What should be the gap between last intake of Citalopram and intake of Cocaine?

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Posted on Wed, 18 May 2016
Question: I want to know how long before taking cocaine one needs to stop taking citalopram in order to avoid a seratonine syndrome...

doctor
Answered by Dr. Shubham Mehta (13 minutes later)
Brief Answer:
Atleast 36 hours.

Detailed Answer:
Hello
Welcome to HCM.

In my opinion, there should be a gap of atleast 36 hours between last intake of citalopram and intake of cocaine.
This should not cause serotonin syndrome.

Hope it helps.
Thanks.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Shubham Mehta (19 minutes later)
So I do not need to fully go off Citalopram right? Basically I do not need to wait say one full week and go through withdrawal syndrome right?
doctor
Answered by Dr. Shubham Mehta (35 minutes later)
Brief Answer:
Need not go off it fully.

Detailed Answer:
Yes, it is not necessary to completely stop citalopram. This will prevent withdrawal symptoms.

Thanks.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shubham Mehta (23 hours later)
PS I am being a bit paranoid here, but can you briefly explain me why 36hrs should be enough?

After how long can people start taking citalopram again?

This is the last one.

Thanks
doctor
Answered by Dr. Shubham Mehta (19 hours later)
Brief Answer:
Half life.

Detailed Answer:
Hello again.
Sorry for late response.

I say 36 hours because the half life of drug is 36 hours. The risk of serotonin syndrome would be substantially reduced after this period.

In my opinion, the half life of metabolites of cocaine is upto 6 hours.
Citalopram can be restarted after this period.

Hope this answers your query.
Thanks.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Shubham Mehta

Psychiatrist

Practicing since :2008

Answered : 2122 Questions

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What should be the gap between last intake of Citalopram and intake of Cocaine?

Brief Answer: Atleast 36 hours. Detailed Answer: Hello Welcome to HCM. In my opinion, there should be a gap of atleast 36 hours between last intake of citalopram and intake of cocaine. This should not cause serotonin syndrome. Hope it helps. Thanks.