Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

152 Doctors Online
Doctor Image
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

What is the pattern of secretion of adrenal androgens?

Answered by
Dr.
Dr. Uma Rajah Ananth

Pediatrician, Neonatology

Practicing since :1970

Answered : 891 Questions

default
Posted on Mon, 24 Dec 2012 in Growth and Development in Children
Question: Hi,

What is the pattern of secretion of adrenal androgens.....does a measured amount during a lab test indicate a 'one off ' secretion or a number of seperate secretions/bursts? Hope you can make me understand .Thanks for your advice in advance.

XXXXXXX
doctor
Answered by Dr. Uma Rajah Ananth 1 hour later
Hi,
Welcome to HCM

I find that you are asking very interesting questions from morning about Cortisol,ACTH and now adrenal androgens!!!

Are you a Clinical Researcher or allied health professional?

In this forum where we usually give clinical advice and guidelines for investigations and management,I wonder whether we can answer to your satisfaction.

However I will try!

The DHEAS concentration is usually stable through out the day and can be measured any time of the day .
The timing of the test does not affect the test.
So this means that it is not secreted in pulses.

This is unlike cortisol.
Cortisol is highest after waking and very low at bedtime.

ACTH is tested usually in the morning at about 8 am and has circadian rhythm like cortisol.

Its levels are opposite to that of ACTH.
But your questions of how many pulses in children ,I can not answer. Sorry!

All the best
Regards
Dr Uma



Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
default
Follow up: Dr. Uma Rajah Ananth 2 days later
DEAR Doctor,

I read somewhere that HPA maturation during adrenarche leads to HPG maturation after approx 2 years in a boys. What is the reason for this, is it due to cortisol secretion?

Thanks and Best Regards,
XXXXXXX
doctor
Answered by Dr. Uma Rajah Ananth 41 minutes later
Hi XXXXXXX,

It seems logical to think like this!
But literature mentions that in pubertal development adrenarche can start around 6- 9 years but the effect on height increase continues well into teens and even up to 20 years.
So both axis are emerging into new patterns of regulations and growth. There is great variation in individuals in this timing ,rate of change and coordination of these changes .
There is role or leptin and insulin sensitivity which seem to be associated with HPG axis.

Thanks
Dr Uma

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
default
Follow up: Dr. Uma Rajah Ananth 12 minutes later
Thank you for the feedback,


Are adrenal androgen levels seen after onset of adrenarche sufficient enough to halp stimulate maturation of HPG axis?

XXXXXXX
doctor
Answered by Dr. Uma Rajah Ananth 59 minutes later
Hi
usually yes but rarely can be no, especially in girls eg turner's syndrome where adrenarche is not necessarily followed by gonadarchy.

You can refer to the article in European journal of Endocrinology
August 1, 2011 for more analysis.

Good luck
Dr Uma
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
premium_optimized

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,  
Drug/Medication ,   ,  
Medical Topics ,  

Recent questions on  Cortisol

doctor1 MD

I was gardening in the morning with garden gloves, big sun hat & big white long sleeve high collar shirt under the strong sun, because I burn badly. That evening suddenly my lower arms between the elbow & wrist are covered with bunch of red spots. At first I thought they are from the bugs, so I put the over the counter insect bite cream. It didn t help at all after frequent application overnight. They Itch badly, tiny dot size to 1/4 diameter, some have white or clear pointed center. I remembered I had a similar incident about 3 months ago on my lower legs & went to the dermotologist. She prescribed fluocinonide cream usp 0.05%, so I have been appling it this morning, but no improvement. Should I give more time ? I also have proctozone-HC TM 2.5% ( hydrocortisone cream usp 2.5% ) prescribed from another doctor. Is this the same as the first cream ? May I use ths instead or use it after the first one is gone ? How often may I use per day & how long may I use ? Or do I have totally another problem ?

doctor1 MD

Hi. I visited the doctor the other day, because I have numbness in my arms and fingers and palpitations, and so I was worried about my heart. They took bloods which showed I am anaemic. They also did an ekg and I am really worried now because they said it was abnormal. The doctor said there was a tiny bump which should be on a certain part, and it wasn't there, but that it "wasn't a big problem". The doctor also said the 2 leads which showed that issue with the bump were the ones under my breasts, and that "you have quite large breasts, so that could have cause this result". I told the doctor I am also really tired and stressed and she said also took some blood to test for low cortisol and low B12. I am awaiting the results. She said the symptoms I was describing were not to do with my heart. I have been referred for a stress test which I will do 4 weeks today, but I'm terrified that something is seriously wrong with my body and/or my heart. Please help me. I think the doctor is being pretty pro-active, but I'm so worried :-(

doctor1 MD

I have a condition called ballinitus which I have controlled for the past 12 years with trimovate cream. This was prescribed by a consultant I saw and I only used a tiny amount each year, and got a new tube when it went out of date . My current GP has prescribed 1% hydrocortisone cream instead but this does not seem to be as effective

doctor1 MD

I have 2 bites, about 3/4 across and close together, not raised, on my upper arm, close to arm pit. They itch like crazy and burn slightly, all the time. Have tried anti-itch creams, hydrocortisone and cool wet cloths but nothing seems to help. They have been there two days. What can I do? Should I see Dr.?

doctor1 MD

I HAVE HAD HYPOTHYROIDISM FOR WHAT SEEMS LIKE FOREVER. I HAVE GONE TO MANY DIFFERENT DOCTORS AND ALL THEY DO IS GO BACK AND FORTH WITH THE DOSAGE OF SYNTHROID AND IN THE MEANTIME, I AM EXHAUSTED, MY JOINTS HURT, AT THE MOST RIDICULOUS TIMES-MY...

doctor1 MD

Started fever 11 days ago. Nodes in 2 areas of neck swollen but better. Left arm near elbow broken out and itches. My right entire side of back is totally broken out. If i scratch seems like fluid inside. Very small breakouts but covers entire...

doctor1 MD

My daughter is obsessed with seeing people in pain. She watches movies and vid of people in pain all day long and thinks abour it to all day long. whats wrong?