Brief Answer: yes, you can apply topical medicine. Detailed Answer: Hi, I have read your query and I feel I could help you with it. You have not mentioned any history of diabetes /hypertension. Painful and red leg may be due to claudication , cellulitis, so i need more details about your condition. Please also mention which part of of your leg is red and painful e.g above thigh region or below knee region. Also mention if there is any history of fever,weight loss,night sweats,swelling in joint. You may consult your doctor as he may physical examine you or advise you some investigations like colour doppler to see conditions of blood vessels of your leg. He may also advise you some x-rays of your leg. After your physical examination and tests mentioned above, send us the reports. Then i will advise you further management. In the mean time you may apply topical declofenac ointment, two times a day for pain in leg. Do not simply take any painkiller without proscription of any doctor,as these medicine need to be carefully monitored by doctor. You have to elevate your limb while night or when you are sitting. Since your leg is painful and red, apply crepe bandage from your foot to thigh. I hope you have get your answer.You are welcome to ask further health related queries. Regards

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