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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What is mitochondrial dysfunction in Parkinson's disease?

Answered by
Dr.
Dr. Erion Spaho

Neurologist, Surgical

Practicing since :2004

Answered : 3656 Questions

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Posted on Tue, 23 Aug 2016 in Brain and Spine
Question: What is mitochondrial Parkinson's?
doctor
Answered by Dr. Erion Spaho 3 hours later
Brief Answer:
Mitochondrial processes affected by different substances.

Detailed Answer:
Hello and thanks for using HCM.

I have read your question and understand your concerns.

Mitochondrial Parkinson's disease refers to Parkinson's disease that may be caused by substances that affect mitochondrial processes such MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

MPP accumulates in mitochondria and interferes with the function of complex I of the respiratory chain. A chemical resemblance between MPTP and some herbicides and pesticides suggested that an MPTP-like environmental toxin might be a cause of Parkinson disease, but no specific agent has been identified. Nonetheless, mitochondrial complex I activity is reduced in Parkinson disease, suggesting a common pathway with MPTP-induced parkinsonism.

Hope you found the answer helpful.

Let me know if I can assist you further.

Greetings.
Above answer was peer-reviewed by : Dr. Priyanka G Raj
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