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What Is An Effective Test For HIV?

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Posted on Mon, 4 Aug 2014
Question: Dear Dr,
Thanks for your reply.
As what i said i did the Elisa combo test after 23 days, and the result is negative.
The case is i had unprotected oral sex on 3rd of XXXXXXX And i took the combo test. Is the test reliable ?
And made me very stressful is there are some symptoms appear these few days like mild sore throat and swollen gland not feeling well, white tongue, and low fever appear for one night.
And painful feet.
It drive me crazy. Dr pls give me some advice!
doctor
Answered by Dr. Sanjay Kumar Kanodia (2 hours later)
Brief Answer:
symptoms are not of ARS; Go for RNA PCR

Detailed Answer:
Hello,

Welcome and thanks for posting your query to the forum.

I can understand your concern for HIV after unprotected intercourse.

Let me first reassure you that your symptoms are not at all matching with typical Antiretroviral syndrome or also known as ARS of HIV.

In ARS there is high grade fever with typical rash and frankly enlarged lymph nodes. The typical of symptoms are like patient says "worst flu ever".

So getting to your symptoms I can not find high grade fever, no rash and not severe of sore throat.

For lymph gland enlargement - I very often see young men like you coming and complaining of node enlargement but on examination I find that they perceive the normal structure of muscles and other normal tissues as nodes.

White tongue is generally a sign of dehydration and stress.

So getting to all the points your symptoms are not typical of ARS and rather are part of anxiety and stress due continuous thinking and reading about of HIV.

Regarding your combo test- Before I guide you for the test let me first guide you about the standard protocol which we follow and about HIV infection:

In an unprotected intercourse with a HIV positive person the HIV viruses gets entered into the body and divides in innumerous numbers(millions of viruses per ml).

After a period of 2-6 week there is mounting of antibodies against the viruses. These antibodies can take at the maximum of 8-10 weeks of the period to get expressed.

Therefore the infection can be analyzed by two ways -

-A): By HIV virus detection: done by RNA- PCR. It tells us the number of copies of virus present in per ml of blood. By the latest of methods the viruses can be detected within 2 weeks of period.

B): By HIV antibody Detection: As told earlier once the antibodies can appear from 4th week to maximum of 8-10 weeks and then these antibodies to HIV virus persist throughout life.

The protocol of the antibody tests done for HIV is as follows: One HIV antibody test at 6-8 weeks and then a follow up final test at 3 months (84 days or 12 weeks).

Antibodies once formed to HIV can never disappear. So if a person has HIV infection, 3 months of period is the time when we say to be fully sure of whether HIV is present or not on the basis of antibody tests.

Now correlating all the facts and interpreting with your situation:

- It is good that your ELISA combo at 23 day is negative but we take this test most conclusive at 84th day.

- A RNA PCR test is of best help in all the anxious cases who do not want to wait till even till 6 weeks -12 weeks.

So to relieve all the anxiety I suggest you to go for RNA PCR.

Rest I again reassure you that your symptoms are not at all matching with HIV illness and therefore do not worry about the same.

I hope above informations will clear your doubts. I will be glad to answer any further of your queries.

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (14 hours later)
Dear Dr. XXXXXXX
Thanks for your reply. I 've done the RNA test this morning .
And can you give me some ideas about my combo test result in 23 days is negative. Will it be reliable in the fourth generation? I m very wory about the RNA result....

r
doctor
Answered by Dr. Sanjay Kumar Kanodia (29 minutes later)
Brief Answer:
RNA PCR will give you the peace of mind

Detailed Answer:
Hello young man,

Thanks a lot for further follow up.

This is good that you have gone for RNA PCR test. This is the best test at this situation and will relieve all your anxiety and fear regarding HIV. I was reading other of your queries and analyzed all of these. After reading all with diligence, in my experience depending upon the type of exposure your test will come negative and give you the peace of mind. Therefor you need not to think negative in this manner.

As I said earlier- Combo test is quite sensitive now a days but we consider more reliable around 6th week and best at 12 weeks. But as I can see your anxious state and we can not wait till 6 week and then again repeating at 12 weeks so I suggested you to go for RNA PCR.

I am waiting to hear for the negative result of your RNA PCR test. Do give me a follow up of negative test result.

"My best wishes for your healthy life"

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (1 hour later)
Dear Dr XXXXXXX
Thanks for your kind wording. May i ask you what will be the probability the 4th combo test is negative and the RNA test come out a positive?
By then, did u see these cases often??????
doctor
Answered by Dr. Sanjay Kumar Kanodia (6 hours later)
Brief Answer:
Negative at around 12 weeks- Negative RNA PCR

Detailed Answer:
Hello young fellow,

Thanks for your follow up.

For the correlation between 4th generation combo test and RNA PCR- In my experience if the test is negative at around 6 weeks then the chances of positive RNA PCR are very low. A 12 weeks negative combo has never shown positive result for RNA PCR.

Now young man stop thinking about HIV and keep yourself calm. DO not sit alone and read matter other than HIV.

Do give me follow up of your result.

All my best wishes for you.

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (44 minutes later)
Dear Dr, XXXXXXX
I really feel bad and always checking the symptoms on my body, like this evening i feel my armpit swollen lymph node after i drink a glass of water.
And white tongue is more serious ... And littlw alin rash. Even Dr XXXXXXX said my symptoms are not from HIV infected , i went to see my 2 Family Drs
they said the same. But i still will think it is because pnly 4 weeks , most of the symptoms will appear in 5 & 6 week......So my armpit problem drive me crazy now......
Dr Am I HIV Phomia?
Have you ever seen a patient got all the HIV earliest stage symptoma?

Regards
Honestly i already not sleep well for a few weeka . Only aoruns 3 houra a day.
doctor
Answered by Dr. Sanjay Kumar Kanodia (14 minutes later)
Brief Answer:
HIV symptoms never comes before 5-6 weeks

Detailed Answer:
My Dear young friend,

It is quite common to find your kind of situation quite often. I very frequently counsel and examine your sort of patients with deep fear of HIV.

It is so bad that 24x7 person is thinking only of HIV.

As I guided you ealrier that in ARS there is high grade fever with typical rash and frankly enlarged lymph nodes. The typical of symptoms are like patient says "worst flu ever". You do not have high grade fever, no rash and not severe of sore throat.

For node enlargement in arm pit- I very often see young men like you coming and complaining of node enlargement but on examination I find that they perceive the normal structure of muscles and other normal tissues as nodes. Similarly for white tongue too is generally a sign of dehydration and stress.

I have never seen any patient with HIV symptoms before 5-6 weeks. So do not worry about the same.

I reassure you fully that as per my experience your test will come negative. As a brotherly suggestion do take a good sleep today as bright good future is waiting for you tomorrow when you will receive a negative report of HIV in your hands.

All the best.

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (11 minutes later)
Dr XXXXXXX
Thank for your patience. And sorry for my poor english skill.
Just like what u said my last 2 unprotected oral sex were on 28th May and 3rd XXXXXXX My feared symptomS were all found start on laat week. Mouth ucler, swollen gland not feeling well, low fever for one night, painful fee. And my body feel very weak during thw weekend . Scare of cold.
Dr . XXXXXXX please help me. What you you think of my symptoms -again?'they started at the 4th week.......
doctor
Answered by Dr. Sanjay Kumar Kanodia (23 minutes later)
Brief Answer:
All your symptoms are due to anxiety only.

Detailed Answer:
Dear young fellow,

Your English is quite good and I am very well able to understand your concerns. As I said earlier that I have never seen ARS symptoms earliest not before 6 weeks.

You have your history since 4 weeks only and not beyond that. If we consider your things then these came even before completion of 4th week which is one of the thing in favor that are not symptoms related to ARS and therefore to HIV.

All your symptoms are due to anxiety only.

So relax and now take a good sleep.

All the best.

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (6 minutes later)
DrSanay,
Thank you very much for all your replies!!!
I m very tired! Dr XXXXXXX please sit next to me!
I need you here to support me.
Once again thank you very much and i will update you my status!!!

Thanks
doctor
Answered by Dr. Sanjay Kumar Kanodia (9 hours later)
Brief Answer:
Exhale out all your anxiety and fear.

Detailed Answer:
Dear young buddy,

Very good morning to you.

This morning will bring brighter side of your life which you were lacking from around last few days. I am there with you, just feel my presence and am taking care of all your problem just like your elder brother and one your best friends.

Based on my clinical experience I am cent percent sure that your results will come negative. I invite you to Pink city XXXXXXX to celebrate your good health.

Just take deep breath and exhale out all your anxiety and fear. I am waiting to hear the negative results of your reports.

All the best.

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (14 hours later)
Dear Dr XXXXXXX
May i repeat my caae again?
I had few times unprotected oral sex on 20/5, 28/5 and the last time was on 3/6. And i did an instant blood test and had a negative result, then i did a fourth generation elisa combo test on 26/6 and a negative result received on 27.
I already not sleep well for 2 months, just around few hours a day.
Since last week, there were some symptoms show up in order. First my swollen gland not feeling well, then mouth ucler, low fever for one night. Then my legs not feeling well and feet are painful. Then i not my armpit not feeling well, and there are few cold sores appear these few day around my lips. And mild diarrhea this morning. And i felt my body water expansion today.I feel very stressful. is the combo test negative is wrong? I did a RNA test yesterday and result will be on coming thursday.
Please give me some advises , am i infected?
Regards
doctor
Answered by Dr. Sanjay Kumar Kanodia (10 hours later)
Brief Answer:
Your symptoms do not match wiht HIV

Detailed Answer:
Hello young buddy,

Welcome to the forum and thanks for your further follow up.

I have gone through your query again and analyzed each and every point very diligently. As I said earlier, none of your symptoms matches with HIV and its related Acute retroviral syndrome(ARS).

Let you understand each and every point in detail-

- In ARS three is swelling of multiple nodes and not a single node.

- There is fever of high grade remaining for atleast minimum of 7 days to up to 14 days. Your fever remained only for one day and that too of low grade which has no significance in HIV.

- Mouth ulcers are not XXXXXXX manifestation of HIV and anybody can have oral ulcers due to stress.

- Restless legs are again due to stress and anxiety and are not symptoms of HIV proper.

- Cold sores is very common to occur due to stress so do not correlate it with HIV.

- Diarrhea is a broad term and we should have at least passage of 4 or more stool of lose consistency to designate diarrhea. SO do not think only of HIV.

As I said based on all these facts as well as type of exposure you have is not giving any indication of HIV. That is why I am cent percent confident that your test of RNA PCR will come negative. I suggested you RNA PCR only for the part of giving you a medical proof in your hand therefore the confidence that you are clear.

I am always there with you as your friend to take care of your any kind of issues. Just feel my presence besides you. Do not sit alone. Read good books and positive motivating things.

Please for God sake do not read anything on HIV till you get your report. It is now matter of short time till you get your report so do not get anxious.

My all best wishes for your good health.

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (14 minutes later)
Dr XXXXXXX
Thanks for your patience and kindness.
Thanks for understanding why i being so nervous.
What js thw probability my report will be positivw tomorrow? Or i can ask what is the percentage of the fourth generation would giving out a false negative in 23 days?
My diarrhea seems more serious today......

I cannot sleep at all
doctor
Answered by Dr. Sanjay Kumar Kanodia (41 minutes later)
Brief Answer:
Relax yourself and do not get anxious

Detailed Answer:
Hello young buddy,

Thanks for your swift follow up.

As I said earlier, combo test for HIV is very much authentic and reliable. But if you read out my earlier clarifications, there is a specific time period for the test. We consider it more reliable at 6 weeks and most at 12 weeks. So there is no question of false negative result of the test done at 23 days.

I feel that you are becoming very much anxious as the time period of result is coming closer. Diarrhea is not an early symptom of HIV. In your kind of anxious situation I quite often see persons complaining of frequent motions. It is quite common due to anxiety. I also remember my student days when I quite often felt condition of diarrhea before examinations or before results. Please do not get anxious and take a good company of a friend. DO not sit alone and think anything about HIV.

I am cent percent confident that your test of RNA PCR will come negative.

My all best wishes for your good health.

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (50 minutes later)
Dear Dr. XXXXXXX
I m still very nervous bcoz when u mentioning aboout ARS. I got sore throat since last thursady and swollen gland not feeling well after. Then i found my tongue quite white in color in the inner part, then i felt very tired.... Joint paiunful..... And yesterday start not feeling well with my armpit on monday. The start diarrhea yeaterday. But just very low fever on last wedneaday night. I know i m very terrify....by then what is "Infectious mononucleosis"?
And will be the symptom skin rash next?......
doctor
Answered by Dr. Sanjay Kumar Kanodia (1 hour later)
Brief Answer:
High grade fever in "Infectious mononucleosis".

Detailed Answer:
Dear young buddy,

So still you are reading a lot on internet to find out the cause. It is not at all "Infectious mononucleosis" too. In that too there is high grade fever. In all the HIV patients I have seen clinically, I observed the most important symptom of high grade fever. In "Infectious mononucleosis" too there is high grade fever.

You never had high grade fever till now. If your symptoms would had been of HIV then before all the symptoms you enumerated you would have complained of fever of high grade- which is actually not !!! So none of your symptoms are actually matching with either HIV or "Infectious mononucleosis".

You will see that as soon as you will find your negative report you will be relieved of all your symptomatology.

Be there with me and do not fear of anything.

My all best wishes for your good health.

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (38 minutes later)
Dear Dr XXXXXXX
Will the ARS pharyngitis very serious or just mild?

Regards.
A
doctor
Answered by Dr. Sanjay Kumar Kanodia (7 hours later)
Brief Answer:
Pharyngitis is very troublesome in HIV

Detailed Answer:
Hello young buddy,

Welcome again and thanks for your follow up.

Regarding pharyngitis- it is very troublesome and is told as worst kind if sore throat or flu like symptoms in life.

I don't think that you have this kind of sore throat. So try and relax yourself.

With all my best wishes,

Dr Sanjay Kanodia
MD-DERMATOLOGY & Sexually transmitted diseases.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (11 hours later)
Dear Dr. XXXXXXX
Once again, thank you very much for your support!
And very sorry for my poor english skill.
My RNA report is Negative.
Can you teach me and give me an idea of the next step of checking sedcuhele? Or planing? And teach me how to not too nervous when facing problem?
I really do believe in you!

May i have your address? So that i can send me something for my thanksgiving.

Regards.
A
doctor
Answered by Dr. Sanjay Kumar Kanodia (8 hours later)
Brief Answer:
I'm extremely happy to know the negative result.

Detailed Answer:
Hello young buddy,

I am extremely happy to know that your RNA PCR result is negative. It is a really best news you have given to me. I am sorry to reply you bit late as I was at remote place without net ccess. I can't tell you how eager I was to hear from your side that you are completely alright.

I was cent percent sure that your result willbe negative and you are clear and healthy. Now as your result of the test is negative so you need not to go for any further testing. This is full and final thing and you do not require anything beyond this. Do not waste your time and money in any further testing.

Now in few days you will feel that you are getting better and better. It will take few days for you to come out of the aura of HIV possibility. Take breath and relax my dear young fellow.

Your healthy report in your hand and lovely smile after that is the best gift for me.

I invite you to XXXXXXX and do meet me whenever you are coming to XXXXXXX My address is there on my Web page. It is

C 90
Sethi colony XXXXXXX ( XXXXXXX )
India- 302004

Stay in touch with me. I further suggest that you always do safer sex with condoms to reileve any tensions in future. Condoms provide the best mode of protection in all STDs.

Enjoy your day with best zeal and I am there with you as always.

My best wishes for your healthy life ahead.

With regards,

Dr Sanjay Kanodia
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (10 hours later)
Dr. XXXXXXX
Thank you! It's always glad to reveive your reply.
In the past few days, i was really stressful and anxiety. So my family dr, gave me some nalion 0.25mg and Xanax 0.25mg to make me not too anxiety , and stipidem 10mg to improve my sleep quality. But i found that i have symptom diarrhea after the medicine , will these medicine make any side effect?
doctor
Answered by Dr. Sanjay Kumar Kanodia (5 hours later)
Brief Answer:
Stop the tablets & stay healthy without any tablet

Detailed Answer:
My dear young buddy,

Thanks a lot for your reply and follow up.

You must be feeling quite relaxed now and I hope that the most of the symptoms which you were feeling are partially receding now. It is quite common that till the time you are terrified you feel all the symptoms exactly like you enumerated. But as soon as you get a negative report all of your anxiety and stress starts relieving slowly.

As I said it will also take sometime to accept your brain that you are completely free and clear now. So for few days to weeks you may feel less or more of the symptoms and therefore should not be worried at all.

In my view you should not take any tablets now and do not be dependent on any of these. SO you should stop the tablets and stay healthy without any tablets. Taking these tablet can make you bit dependent and presently there is no need of the same also.

Now the most important thing is to keep yourself busy. Do whatever you were not able to do in last few weeks. enjoy with friends and relax with your family. DO not sit alone and do not give any second thought to HIV again.

Go for a morning walk, d o yoga, see the morning rising sun and give yourself positive thoughts for your future life ahead.

"My all best wishes for a very healthy life ahead- now and always"

Regards,

Dr Sanjay Kumar Kanodia
MD -Dermatology and Sexually transmitted diseases
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (29 hours later)
Hi Dr XXXXXXX
How's your weekend?! Thank you for your encouragement at all time!!!
Honestly, I'm still in very anxious feeling. Dr. XXXXXXX Can you tell me is that mean i had no HIV infected after the RNA PCR test result in negative? What is the probability of false negative prsence in my window perio?
I even scare to touch my lovely daughter!
Dr. Please help.

By the way, thank you for giving me the address. This is very luck to know you!!!!!!d
doctor
Answered by Dr. Sanjay Kumar Kanodia (5 hours later)
Brief Answer:
No window period now. you are healthy.

Detailed Answer:
Dear young buddy,

I am enjoying my weekend and hope you must be enjoying your weekend too.

Fine my dear friend, so you are still worried about any possibility of HIV till now. You shouldn't be at all.

If you are still reading that there is some kind of window period now then it is not correct.

Let you understand about window period: window period is actually the time from entrance of any infective organism like HIV and then it's detectability by various methods.

So this window period is variable from one test method to the other. In combo ELISA it is minimum 6 weeks to maximum 12 weeks. In RNA PCR it is minimum 7 days to maximum 14 days.

In yourself it was more than 1 month after which the test was done for RNA PCR. It is more than enough of the time to detect HIV virus. Had it been positive then would had been positive by 14 days itself.

So do not get confused with window period at all. You are completely healthy and there is no need to fear.

Give your family and especially your lovely daughter the best of love and affection you can give!!!

As I said you may feel consciousness for some time but it is but natural for you.

You are totally healthy and there is no need to worry. I am always there with you to clear any of your doubts.

My best wishes for your great weekend!!!

Cheers & enjoy!!

Dr Sanjay
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (9 hours later)
Dr. XXXXXXX
Thanks for your reply.
Is that mean there is only two answers with the RNA test, positive (infected) or negative ( no infected ).
What will be the other factors to give out a false negative result?
My neck and armpit lymph still not feeling well ( not hard but little bit swelling ) and some red dots appear on my left front arm already few days(see photo).And my throat still not feeling well..... Body hot but not fever......what happen to me?
I m very tired with my anxiety.....
doctor
Answered by Dr. Sanjay Kumar Kanodia (31 minutes later)
Brief Answer:
Reduce your anxiety.

Detailed Answer:
Hello young buddy,

Good morning with Sunday breeze of relax.

So you got it correctly that there is no if and buts in RNA PCR. It is either positive or negative. It is only negative in those HIV persons who are taking anti retro viral drugs(anti HIV drugs) from long time.

Therefore you should not be worried about anything. It is negative means completely negative.

For your rest of the symptoms:
- the rash is simple heat rash which can occur to anyone and is totally nonspecific.

- the rest of the symptoms are due to anxiety and stress. Our brain perceives all the things in the same manner as we read or perceive. So as you have felt in the same manner like you had HIV, therefore it is quite obvious that your brain will take sometime to accept the negative status.

That's why I am saying to relax yourself and do not think of HIV now.

spend your quality time with your family and give my love to your daughter with regards to all your family members.

My all best wishes for your good health.

With regards,
Dr Sanjay Kanodia
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (12 hours later)
Dear Dr XXXXXXX
I know you always do the best for me to make me not too worry.
But may i ask you a question? Why people nesd to keep the tests after their RNA PCR test is in negative result?
I saw so many people here they keep do the tests after 5, 6, ....weeks....i still feel very anxiety!
I know i should believe the report result. But i cant.

Regards
doctor
Answered by Dr. Sanjay Kumar Kanodia (2 hours later)
Brief Answer:
RNA PCR is the god standard of HIV testing

Detailed Answer:
Dear Young Buddy,

I hope you enjoyed your Sunday with your best zeal..atleast better than last few Sundays !!

Regarding repeated testing by people- This is actually everyone's personal issue to get tested again and again. They keep on presuming that they might be infected with HIV.

I believe in scientific and medical facts and not just presumptions. I also see quite a many persons who keep on checking and go for repeated testing despite negative results according to protocol and timeline of test authenticity.

As best of my knowledge I again reassure that there is no further testing required. This subject of HIV is made sometimes so complicated that everyone tries to make his or her own assumptions and interpretation.

Since 1985 till now in last 30 years there have had been lot of changes in the testing protocols according to advancements. In present day scenario at or after 14 days of probable exposure RNA PCR is the Gold standard test. I didn't wanted you to wait for another 2 months of agony and anxiety and to go for ELISA combo at 12 weeks. That is why I suggested you RNA PCR, where the causative organism itself is detected.

When the virus itself is not present then how come the symptoms could be present- you can yourself think of that!!!

The most commonly done test is ELISA combo which is easily available and most of the people are suggested the same which detects the antibody produced by the virus itself. But as per the protocol of this test, one test is done at 6 weeks and repeated at 3 months ( 12 weeks ) as final report. But above and best of this is RNA PCR which detects directly the viruses. Additionally there is no waiting time of 6 weeks first and then later for next 6 weeks of waiting again.

Just think of persons who have to wait for complete 12 weeks and the mental agony and trauma they feel for this complete period. In this anxious state they keep on repeating test every now and then .. every weeks!!!

I have counseled so many people when this RNA PCR was not available and could feel the kind of agony which they felt.

I am sharing all these facts as you like my younger buddy who also require to all these facts.

So you just relax for any possibility of HIV, you are totally clear and healthy. This is also a fact that our mind takes time to get itself out of the aura of HIV.

So sleep today with the sweetest of dreams and new horizons to see tomorrow's great morning.

I am there with you to clarify any doubts just like your best buddy!!!

With regards,
Dr Sanjay Kanodia
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (21 hours later)
Dear Dr XXXXXXX
Hi! Thanks for your reply and support!!
The attachment is my EBV test result today!
It's a positive result . I felt so bad.....
Dr. XXXXXXX what is EBV ? Any relationship between HIV and EBV?
Can you give me some advise?

Regards.
A
doctor
Answered by Dr. Sanjay Kumar Kanodia (2 hours later)
Brief Answer:
EBV, is one of the most common human viruses

Detailed Answer:
Hello my dear young buddy,

Welcome again and thanks for your follow up.

I am there with you to clear all your doubts and worries.

I have gone through the complete report of EBV and after interpreting it with diligence let me again reassure you that this report has nothing to do with HIV or your present state of symptoms (which are solely due to anxiety only).

Let me first tell you that the report just tells you regarding past infection of Epstein-Barr virus (EBV) almost of indefinite period or multiple years back. It has no relation with HIV virus or other things.

Now regarding EBV- Whenever we talk of this virus we say Epstein-Barr virus, or EBV, is one of the most common human viruses in the world. To tell you more importantly as per the data most people will get infected with EBV in their lifetime and will not have any symptoms. We ourself are not able to remember when we can get infected with this virus.

So you can see that it is not at all uncommon but one of the commonest viral infections seen in world. I don't know why you have gone for the report, probably after reading on internet regarding Infectious mononucleosis and thus to rule out the possibility of the same.

But lucky man, your reports do not show any recent infection of EBV and thus for infectious mononucleosis. If you can see the report then can interpret that none of IgM antibody is positive and only IgG antibodies are positive.

IgM antibodies are positive in recent infection, say for within a period of 2-3 months of exposure. IgG antibodies are positive in case of past infection of many months to years to indefinite period. All of might get infected with EBV in childhood and can show positive IgG antibodies. You can see that both Anti aVCA and Anti EBNA IgG are positive. The presenace of antibodies to both VCA and EBNA suggests past infection (from several months to years earlier).

This EBV is so simple virus that it can get spread by sharing drinks and food
using the same cups, eating utensils, or toothbrushes or simple kissing and toys etc.

So probably you are able to understand the simplicity of this virus and because your IgG (and not IgM) is positive which shows a past infection of indefinite nature.

So cheer up Bro!!!

Be tension free, relax and enjoy the evening !!!

I hope it cleared all your doubts, let me know if you still have any doubts left.

With regards and best wishes,

Dr Sanjay Kanodia
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (18 hours later)
Dear Dr. XXXXXXX
I'm still very confuse.
I have few questions. I read some articles said people may have HIV infected that's why made EBV virus show again. In my case, what do you think?
I m worry about my 23 days combo test is not enough for the window period.
What other test i can do to make my self clear i m not being infected?
Are the symptoms of EBV are very similar to HIV infected? I m very worry....even the RNA PCR test is negative....

Dr. XXXXXXX please help.
I 'm going crazy....
doctor
Answered by Dr. Sanjay Kumar Kanodia (6 hours later)
Brief Answer:
There is no HIV or EBV or any other thing

Detailed Answer:
Hello young buddy,

Welcome again to the forum and thanks for further follow up.

As far as your present concern for EBV and HIV are concerned let me reassure you that there is no such issue which is there in your mind.

Let me guide you again:

You can see by yourself that its IgG basically which is positive and none of the IgM antibody is positive. So this IgG can be positive in me, you including all the individuals who have had exposure so many years back in past. IgG positivity has nothing to do with your present exposure.

Had it been IgM positive state I would have definitely had taken your status accordingly. But as you can see it is only IgG which is positive so has nothing significant.

You are correct that in some articles it is written that EBV is again positive in HIV. Let me add that it is not HIV alone where EBV is positive, it can be positive in so many other states too. But my dear buddy if such a thing of EBV reactivation could happened then it would had been IgM which showed its positive state and not IgG.

For HIV you have gone for the best test in the world which has no comparison. The technology of the RNA PCR detection is best in this world and no there test can be compared with it. If you are comparing RNA PCR with ELISA combo then is same like comparing an aeroplane with a car. RNA PCR is the final answer to every HIV test.

So do believe in me, you have trusted me since the beginning of the discussion. I am not guiding you as my patient but as a friend and as a young buddy itself.

There is no need of any tests further. It would be mere wastage of your money and time.

Do not read anything related to HIV and or EBV or any other thing. My dear I want to say that you are presently talking to an expert. No internet knowledge can give you complete knowledge. Internet is studded with immense and vast knowledge but without proper guidance is either dangerous or misguiding.

So I finally say that you are clear and there is no HIV or EBV or any other thing is present in you.

I hope it cleared all your doubts, let me know if you still have any doubts left.

With regards and best wishes,

Dr Sanjay Kanodia
Dr Sanjay Kanodia
MD-DERMATOLOGY & Sexually transmitted diseases.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (7 hours later)
Dear Dr. XXXXXXX
Thanks for your reply.
Yes, you reminded me I m asking an expert. I always believe in you!
Sorry for my poor english skills again, is that mean if i got hiv infected , my EBV IgM antibody should be positive? Or i can say my exposure in 4-5 weeks ago, if i got hiv infected, should made the IgM positive?
So the anixety made the EBV virus IgG activate again, and EBV symptoms are similar to ARS symptoms? Because i got most of the symptoms like sore throat, the feeling of neck lymph and armpit lymph feeling larger, heat rash, headache, my excreta not solid,

Dr. XXXXXXX , i believe in you. But i m very nervous
doctor
Answered by Dr. Sanjay Kumar Kanodia (4 hours later)
Brief Answer:
No EBV and No HIV

Detailed Answer:
Hello young buddy,

Very Good morning.

Your English skills are very good and I am able to understand each and every of your concerns and emotions behind every query.

So still you have bit confusion. Let me clear the clouds of confusion:

- As I said you have IgG positive in report. It is a good thing not a bad thing. it doesn't mean that you have EBV positive state. It just shows that you have immunity and protection for EBV. IgG has not been activated now, it is been present since so many years. It is just incidental that out of anxiety you gone for the test and found IgG which is a protective antibody and therefore it does not mean active EBV state.

Now for your other of the symptoms, you can notice that there is no fever of high grade and continuous for 7 days. This was one of the most important clinical symptom which made me to declare clinically that the symptoms you are experiencing are not related to ARS.

Had it been ARS then a high grade fever is/was must to accompany your other symptoms. I so often see your kind of condition where the person is so much anxious and the most important guiding symptom is fever.

So the symptoms you are experiencing are not uncommon in anxiety conditions. I again reassure you for "NIL possibility" of either HIV or EBV.

Your reports are based on scientific and medical facts and best technology and can not be fake. You have to believe in your reports which are not just assumptions. Your reports are like sunlight which throws a crystal clear light on your clean status. Do not worry and please do not read anything anywhere on net. Do not search anything from internet now as is the most important cause of anxiety in your kind of situation and cases.

I am with you as always to support you and clear your confusions for any of your issues.

With my best wishes for your healthy life.

With regards and best wishes,

Dr Sanjay Kanodia
MD-DERMATOLOGY & Sexually transmitted diseases.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (12 minutes later)
Dear Dr. XXXXXXX if about the ARS high grade fever, when will it normally happen after the esposure. I just suddenly alert about the HIV infected about 2 weeks ago. From 4th XXXXXXX to 2x XXXXXXX maybe i really not feeling myself fever?
My last unprotected oral sex was om 3rd of XXXXXXX So would it be already happened and i never noticed? By then the 24days elisa combo test was done on 27 june? What is the possiblity the antibodies not show up yet?
Also that means HIV infected can cause EBV IgG reactivted?.....not only Ig

Regards.
AM
doctor
Answered by Dr. Sanjay Kumar Kanodia (2 hours later)
Brief Answer:
There is nothing like activation of IgG for EBV.

Detailed Answer:
Dear young fellow,

Welcome again and thanks for prompt follow up.

In ARS the fever starts by 5th to 6 weeks or any time later. It is of high grade (above 102F) and is a continuous fever remains for a week period. It can never go unnoticed and as I told the flu like symptoms are called to be as "worst flu ever".

Fever in ARS or in EBV is must to follow. If there is ARS then there is fever of high grade.

As we have gone for your RNA PCR so your antibodies will never show up as these are not present because HIV is not present.

There is nothing like activation of IgG for EBV. IgG only appears when there is long term immunity is present for the EBV. So do not get confused for any type of reactivation of EBV and therefore IgG.

IgG is good antibody and is not activated now. It is present since long time and has not been activated presently.

Just relax and please do not get preoccupied with HIV and EBV.

I hope thee information will relax you.

With regards and best wishes,

Dr Sanjay Kanodia
MD-Dermatology & Sexually transmitted diseases.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (29 hours later)
Dear DR XXXXXXX
How are you?
It's me again. Due to my anxiety, i went to do an Elisa combo test again yesterday . Fortunately, it's negative result today. I feel much better today. It's a 35 days result.
Dr XXXXXXX can you give me some advise? What's the next step? Or....test day?
Regards
A
doctor
Answered by Dr. Sanjay Kumar Kanodia (2 hours later)
Brief Answer:
I feel happy that you are feeling comfortable

Detailed Answer:
Dear young buddy,

I am fine and hope that slowly you are coming out of your anxiety.

It is not just fortunate but is truth that your status is negative and therefore accordingly the Elisa combo test came negative.

I assure you that the test will be negative at any time because of your clear status. On one side I feel bad that despite the best test being negative you are still anxious, but overall I feel happy also that you are feeling comfortable.

In my opinion there is no need of any test after RNA PCR. I know your status of mind and high anxious level, but this kind of high anxious level can lead to unnecessary tensions.

I quite often see and counsel certain cases who despite being negative in RNA PCR go for weekly test till 12 weeks and then get satisfied that they are HIV negative. When I talk to them and ask the reason then the simple reason given by them is the reading on net and a center point given on net that the test should be negative at 12 weeks. So just to gain confidence and relieve anxiety they try and get tested again and again.

There is no logic in suggesting any next test after RNA PCR and in my opinion there is no need of wasting your money and time.

So relax buddy, just relax and think where are you going.....you are completely healthy and enjoy your life with your family!!!

I hope thee information will relax you.

With regards and best wishes,

Dr Sanjay Kanodia
MD-Dermatology & Sexually transmitted diseases.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (2 days later)
Dear Dr. XXXXXXX
How's your weekend? Thank you for your informations.
I tried not to read anything online in past few days. And just believe on the report results. And try to not trouble you!
I enjoyed a wonderful weekend with my family. But my sore throat , lymphs ( neck and armpit ) and skin on my shoulder( seems some rash) still not feeling well, what happened?
By then, Dr. XXXXXXX what will be the "false negative" possibility in my case? A 23 days combo test, a 27days RNA PCR test, a 35 Days combo test are all in negative results
Can you give me some advise?

Regards,
A.
doctor
Answered by Dr. Sanjay Kumar Kanodia (3 hours later)
Brief Answer:
You are clear means you are free of HIV

Detailed Answer:
Hello young buddy,

Welcome again and thanks a lot for your follow up. I enjoyed a hectic yet very busy and important weekend as a part of my future carrier.

You are most welcome my buddy for any of your issues and don't even think that I am troubled. Rather I feel a satisfaction in my heart to help you come out of the issue.

I am really happy to know that you enjoyed a good weekend with your family without thinking anything for HIV. These are some of the good things which you should do continuously to keep yourself busy and keep your attention away from HIV or related things.

Now one thing you also can notice that gradually the list of your problems are coming down. We started with so many issue and now just three symptoms of sore throat, lymph nodes and rash.

Sore throat can be seasonal, nodes are just a personal perceptions and so is the rash. You can send a picture of rash to me.

There is no possibility of false negative in your case. HIV testing is so precise especially for RNA PCR that there is no issue of false negative. In my clinical practice of so many years I have never seen any false negative case.

Don't be pessimistic pal, we are talking on scientific proofs and not just presumptions. You are clear means you are free of HIV and there is no issues regarding the same.

Once RNA PCR is negative, all your other tests will be completely negative whether combo or anything else and there is no confusion for the same.

So start your work from tomorrow and keep yourself busy. It will divert your mind form any issues of HIV.

I hope it cleared all your doubts, let me know if you still have any doubts left.

With regards and best wishes,

Dr Sanjay Kanodia
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (7 hours later)
Dear Dr. XXXXXXX
Good luck and wish you sucessful !!
Always glad to hear your reply.
The photos are my shoulder skin. Can you have a look for me?
Regards
.
doctor
Answered by Dr. Sanjay Kumar Kanodia (5 hours later)
Brief Answer:
Very mild Rash : not related to any viral cause

Detailed Answer:
Hello young buddy,

Good morning and thanks for your follow up with pictures.

After analyzing the pictures let me reassure you that it is not at all related to any viral rash.

The rash is very mild and even imperceptible. It is simple rash might be related to heat, humidity or synthetic clothes.

had it been viral rash then must had accompanied with fever and generalized deep red rash all over the body.

So rest assured for any rash related to viral origin.

Do saline gargles for kind of sore throat problem you have mentioned.

The nodes can be simple structure of muscles or nearby tissues so do not worry.

Have a busy and productive day.

I hope it cleared all your doubts, let me know if you still have any doubts left.

With regards and best wishes,

Dr Sanjay Kanodia
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (7 hours later)
Dear My Deareat Dr. XXXXXXX

Why i still cannot believe my RNA test result?
I believe in you. Can you tell me more about the RNA test ' s accuracy? I planned to go to another lab to do the RNA test or Combo test to more assure my result, what do you think?
What will be the RSA skin rash like?
Dr. XXXXXXX very sorry. But my feeling is always go up and down.
Regards
A
doctor
Answered by Dr. Sanjay Kumar Kanodia (3 hours later)
Brief Answer:
PCR or combo will be negative.

Detailed Answer:
Dear young buddy,

How was your day...I hope you kept yourself busy!!!

It is quite a natural process to have swings in confidence level for a period of time. It is not unusual with you to feel low at one time and bit high at some other point of time.

The rash is simple thing and not related to any viral agent. I am not able to get RSA. Kindly elaborate about RSA and give me full form.

Regarding restesting: RNA PCR is the only test which detects virus itself and there is no other test which can detect directly the virus particles. If you ask for authenticity of the test and comparing it with any other test then it is like showing torch to sun.
I think you can get from this thing that how much reliable is this test.

In case of going to any other lab- you know from wherever you have gone for the test, it is the credibility of lab which is at stake. Especially for HIV the things are very much sensitive. I have never seen in my clinical practice or heard anywhere about in-authenticity of RNA PCR and wrong reporting.

Even if you go for any test whether PCR or combo it will be negative.

My all best wishes for your good health.

With regards,
Dr Sanjay Kanodia

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (34 hours later)
Dear Dr. XXXXXXX

Thanks for your reply.
I did another 4th generation Elisa test yesterday , and the result is negative today. It's a 42 days test result. 23 days combo was neg; 27 days RNA PCR test was neg; 35 days combo test was neg; and today 42 days combo test is neg ( I also tested in another lab this time ).

I know you will think i not believe in you, very sorry about that. I just want to make sure i m clear to my family.
Dr. XXXXXXX it's almost 6 weeks after the last exposure. Will RSA stil happen after 6 weeks?
I know you will ask me to believe my RNA test, but i cannot.

Regards
Al
doctor
Answered by Dr. Sanjay Kumar Kanodia (3 hours later)
Brief Answer:
Just relax and keep yourself busy.

Detailed Answer:
Hello young buddy,

Good morning!!!

How you are doing!!! must be relaxed after negative ELISA.

I very understand your state of mind and can judge the positive and negative mood swings eery now and then. It is common phenomenon and do not get embarrassed at all.

As I am saying right from the begining that your status is clean from my side. But I know you want to confirm and reconfirm the things in this state of anxiety.

You go for any number of time the test will remain negative as there is no virus is present in yourself.

Now I got your RSA; It is not RSA but is ARS meaning Acute retroviral syndrome. In yourself there is no possibility of ARS so do not worry about the same.

You are totally clear and spend your time with your family and they require your presence mentally and physically both with them. Even if you are still scared then do not sit alone and have a good company of best friend with you.

Just relax and keep yourself busy.

My all best wishes for your good health.

With regards,
Dr Sanjay Kanodia
Note: Consult a Sexual Diseases Specialist online for further follow up- Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Sanjay Kumar Kanodia

Dermatologist

Practicing since :2002

Answered : 4165 Questions

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What Is An Effective Test For HIV?

Brief Answer: symptoms are not of ARS; Go for RNA PCR Detailed Answer: Hello, Welcome and thanks for posting your query to the forum. I can understand your concern for HIV after unprotected intercourse. Let me first reassure you that your symptoms are not at all matching with typical Antiretroviral syndrome or also known as ARS of HIV. In ARS there is high grade fever with typical rash and frankly enlarged lymph nodes. The typical of symptoms are like patient says "worst flu ever". So getting to your symptoms I can not find high grade fever, no rash and not severe of sore throat. For lymph gland enlargement - I very often see young men like you coming and complaining of node enlargement but on examination I find that they perceive the normal structure of muscles and other normal tissues as nodes. White tongue is generally a sign of dehydration and stress. So getting to all the points your symptoms are not typical of ARS and rather are part of anxiety and stress due continuous thinking and reading about of HIV. Regarding your combo test- Before I guide you for the test let me first guide you about the standard protocol which we follow and about HIV infection: In an unprotected intercourse with a HIV positive person the HIV viruses gets entered into the body and divides in innumerous numbers(millions of viruses per ml). After a period of 2-6 week there is mounting of antibodies against the viruses. These antibodies can take at the maximum of 8-10 weeks of the period to get expressed. Therefore the infection can be analyzed by two ways - -A): By HIV virus detection: done by RNA- PCR. It tells us the number of copies of virus present in per ml of blood. By the latest of methods the viruses can be detected within 2 weeks of period. B): By HIV antibody Detection: As told earlier once the antibodies can appear from 4th week to maximum of 8-10 weeks and then these antibodies to HIV virus persist throughout life. The protocol of the antibody tests done for HIV is as follows: One HIV antibody test at 6-8 weeks and then a follow up final test at 3 months (84 days or 12 weeks). Antibodies once formed to HIV can never disappear. So if a person has HIV infection, 3 months of period is the time when we say to be fully sure of whether HIV is present or not on the basis of antibody tests. Now correlating all the facts and interpreting with your situation: - It is good that your ELISA combo at 23 day is negative but we take this test most conclusive at 84th day. - A RNA PCR test is of best help in all the anxious cases who do not want to wait till even till 6 weeks -12 weeks. So to relieve all the anxiety I suggest you to go for RNA PCR. Rest I again reassure you that your symptoms are not at all matching with HIV illness and therefore do not worry about the same. I hope above informations will clear your doubts. I will be glad to answer any further of your queries. Regards, Dr Sanjay Kumar Kanodia MD -Dermatology and Sexually transmitted diseases