Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
173 Doctors are Online

What does this blood test results regarding mononucleosis indicate?

User rating for this question
Very Good
Answered by

Oncologist, Surgical
Practicing since : 2003
Answered : 177 Questions
My 2 year old daughter was just diagnosed with mono (positive ebv). Initially, they were suspecting leukemia. After the test results were back and said she had mono, they are wanting blood work....cbc. Just curious if her labs reflect ebv or should I be concerned there is something else going on? She had labs drawn on a Thursday and the following Monday. Results are as follows:

Thursday. Monday
WBC 10.6 WBC 15.7 (H)
Hemoglobin 9.9 (L). Hemoglobin 10.8 (L)
Mean corp hgb 30.7 (L). Hematocrit 31.1 (L)
Manual neutrophils 13.0 (L). Manual neutrophils 12.0 (L)
Manual REACT lymphocytes 16.0 (H). Manual lymphocytes 87 (H)
Manual absolute lymphocytes 6.36 Manual absolute lymphocytes 13.66
Smudge cells 52 (H). Sed rate 31 (H)
Also, I just received the following lab results:

EBV AB VCA, IgM- 160.0 (H)
EBV early antigen AB, IgG- 64.3 (H)
EBV viral capsule antigen, IgG- 70.7 (H)
EBV nuclear antigen AB, IgG- <18

EBV interpretation showed the following as positive:
Early phase (EBV-IgM)
Acute primary (EBV-IgM and VCA-IgG)
Convalescence/past (VCA-IgG,EBNA-IgG)
Reactivated (VCA-IgG, EBNA-IgG, EA (D)-IgG)

Following results showed (+ or -):
Acute primary (EA(D)-IgG)
Convalescence/past (EA(D)-IgG)
Reactivated (EBV-IgM)

I know she does have mono but just wanting to know if her labs look suspicious enough to warrant further testing for other possible diagnosis.
Posted Mon, 4 Aug 2014 in Infections
Answered by Dr. Prashant Sharma 2 days later
Brief Answer:
No chances of leukemia

Detailed Answer:
Hi madam,

Many times it is difficult to differentiate between mono and leukemia based on the symptoms alone. So we order tests.

In leukemia peripheral blood film shows blasts along with other lymphocytes, which are not seen in your daughter's case so doctors ruled out that.

In addition reports clearly indicate it to be an infection by EBV, so there should be no doubt now. The treatment for mono depends on the condition of patient, symptoms and the nutritional status of child. The pediatrician looking after her will decide about the treatment. Follow his/her advise. She will be alright soon.

Feel free to ask further.
Above answer was peer-reviewed by
Share on Facebook
Share on Twitter
Share on Google+

The user accepted the expert's answer

Ask an Internal Med Specialist

© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor