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Dr. Andrew Rynne

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Exp 50 years

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What does this blood report indicate?

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Dr. Indranil Ghosh

Oncologist

Practicing since :2004

Answered : 1464 Questions

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Posted on Fri, 30 Jun 2017 in Blood Disorders
Question: Hi,
My MCV has been high for many years (maybe since I was born?): 104 - 106
37 years old, I almost never drink alcohol (I feel bit unwell when I try to drink a few sips), healthy diet with lots of green veggies, fruits, eggs, and also regularly have dairy and meat.
Other out of range results are:
-     L.F.T. : ALT 38 U/L
-     MCH: 33.3 pg (slightly high)
-     White cell count: 3.6 x 10*9/L
-     Iron 45 umol/L
-     Iron Saturation: 77 % Saturation
The iron levels have been in this range for many years (at least 12 years, maybe more)
Also:
Haemochromatosis: C282Y: Heterozygous, H63D: Unaffected

Otherwise, healthy, no known health issue.

Doctors have prescribed blood test recently because I have amenorrhea for many years.
Went off the contraceptive pill 2.5 years ago, and no period since then.
I tried fertility drugs (Letrozole, Provera) but fertility specialist says it does not work because of pituitary gland not secreting enough hormones.

Apart from regularly eating dark (90%) chocolate, I can’t see why I would have high iron and liver issues.
Doctors say I should not have any Haemochromatosis symptoms as I’m Heterozygous.
No known issue in my family.

Do you think my hypopituitarism would be related to those iron abnormalities (and probably liver overload too)?
Any ideas where those iron/liver/blood cells abnormalities could come from??
Many thanks!!!
doctor
Answered by Dr. Indranil Ghosh 14 hours later
Brief Answer:
Unlikely to be hemochromatosis

Detailed Answer:
Hi
Thanks for your query. I understand your concerns.

You are heterozygous for hemochromatosis, it is not a risk factor for hemochromatosis. But it is well known to cause high serum iron and transferrin saturation. These levels are unlikely to cause damage to organs like pituitary. Liver enzyme only borderline elevated and it is nonsignificant. Same goes for mch. Only WBC is bit low which we need to follow the trend.

So we have to find another cause for hormonal deficiency. We can get a MRI of the pituitary. If that also is normal then no cause can be identified and the condition treated symptomatically.

Hope this helps.
Regards
Above answer was peer-reviewed by : Dr. Raju A.T
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