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    What does the survival rate in a hypereosinophilic syndrome patient depend on?

Posted on Fri, 14 Jul 2017 in Blood Disorders
Question: Mother has been diagnosed with HES ( hypereosinophillic syndrome). Her wbc today was 23.6. In your opinion, what is her prognosis? Her symptoms range from hypertention, itching, , cough, shortness of breath, mouth sours, muscle weakness, loose bowels. Her eosinophils have been elevated extremely for more than 6 months. She is 86 years old. Presently, she is being stepped down from prednisone for treatment of ITP. 40mg for a week. From what ive read, HES has no cure, how long in your opinion does she have to live, and what can i expect?
Answered by Dr. Lekshmi Rita Venugopal 1 hour later
Brief Answer:
Prognosis and management of HES

Detailed Answer:
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The survival rate of Hypereosinophilic syndrome is 80% survival at 5 years and a 42% survival at 15 years, which means that 80% and 42% people affected survive after 5 and 15 years respectively.

The prognosis greatly depends on the response to treatment, gene mutation associated, blast/leukemic changes and the extent to which other organs like heart gets affected.

First-line treatment is with glucocorticoids, followed by interferon, Imatinib, and chemotherapeutic agents.In nonresponsive cases stem cell transplantation can also be tried.

She would also need regular follow-up to monitor heart function and pulmonary function.

Please be advised to follow up with a Hematologist for further evaluation and management.

Hope this answers your question
Please feel free to address further questions here


Above answer was peer-reviewed by : Dr. Arnab Banerjee
Answered by
Dr. Lekshmi Rita Venugopal

General & Family Physician

Practicing since :2012

Answered : 3187 Questions


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