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What does the presence of acanthocytes in blood of child indicate?

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Posted on Wed, 8 Jul 2015
Question: should I be worried if my daughter has acanthocytes in her blood
doctor
Answered by Dr. Archana Verma (21 minutes later)
Brief Answer:
Hi

Detailed Answer:
Hi
Welcome to HCM

I completely understand your concerns. Acanthocytosis on blood smear examination is not a normal finding. It can occur in various conditions such as abetalipoproteinemia, liver dysfunction, neuroacanthocytosis, hypothyroidism, myxoedema etc. I would recommend you to the following laboratory tests to find out the reason for this finding in your child:

1. Liver function test
2. Lipid profile
3. Thyroid function test

You may forward these reports along with the clinical condition of your child to me so that I can help you further.
Take care
Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Follow up: Dr. Archana Verma (26 minutes later)
She has had many tests and the only abnormal things are Platelet count high just out of range at 404 and a positive Anti-Gliadin IgG 36 units, does this help at all?
doctor
Answered by Dr. Archana Verma (20 minutes later)
Brief Answer:
Hi

Detailed Answer:
Platelets are in normal range.

Anti gliadin IgG antibody test is a very non specific test for coeliac disease.This can come positive even in food allergies, cystic fibrosis, parasitic infections, Crohn’s disease, and other types of autoimmune GI diseases. These antibodies may also be slightly elevated in individuals with no obvious disease.

Anti gliadin IgG in your child is very weakly positive.

To guide you in a better way, I would like to see her reports including the one's I recommended. Also, you need to tell me her signs and symptoms for which she is undergoing so many tests.

Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Follow up: Dr. Archana Verma (22 minutes later)
she is tired all the time and has fallen asleep in class, on the weekend we went to a birthday party at 2pm and she said she did not feel well and slept on my lap for an hour. She has growing pains (what it's labelled) in mainly her ankle joints often, dark rings under her eyes and is making comment frequently on not feeling well but unable to explain why. They think it may be coeliac but all tests are inconclusive and no-one has mentioned the acanthocytes. She has had the following tests:
HLA Typing for coeliac, calcium & bone metabolism, Iron Studies, Serum B12 and Folate,ESR, Glucose Fasting, Thyroid Function, Tissue Transglutaminase IgA, Insulin (serum), Anti-Gliadin IgG, Anti-Gliadin IgA, Zinc, Urea, Creatinine & Electrolytes, FBP. Her 10 year old sister is Type 1 Diabetic but no other family issues.
doctor
Answered by Dr. Archana Verma (2 hours later)
Brief Answer:
Hi

Detailed Answer:
The tests you have gone for doesn't include liver function test and lipid profile which I had suggested. Liver dysfunction can be associated with the symptoms which are present in your daughter. Also acanthocytosis is seen in these cases. If you upload the investigation reports, it will be better. Many times it gives us a better idea.

Take care
Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Answered by
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Dr. Archana Verma

Pediatrician

Practicing since :2006

Answered : 1129 Questions

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What does the presence of acanthocytes in blood of child indicate?

Brief Answer: Hi Detailed Answer: Hi Welcome to HCM I completely understand your concerns. Acanthocytosis on blood smear examination is not a normal finding. It can occur in various conditions such as abetalipoproteinemia, liver dysfunction, neuroacanthocytosis, hypothyroidism, myxoedema etc. I would recommend you to the following laboratory tests to find out the reason for this finding in your child: 1. Liver function test 2. Lipid profile 3. Thyroid function test You may forward these reports along with the clinical condition of your child to me so that I can help you further. Take care