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What Does The Following VDRL Test Report Indicate?

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Posted on Wed, 24 Dec 2014
Question: Iam looking for 2nd opinion
When was young 20 years a go was having VDRL + and treatment, was not following results on that time.

After check 2 years a go get RPR 1/2 TPHA + not titre results, get a lot of stress, feeling some muscular pain , but not any other clinical and fisical sintoms, any way get 1 Benzetacil 2.4 Nov 2012

in Feb 2013 was in a specialtist VDRL 1/4 TPHA 1/5120 and another get 2 Benzetacil 2.4
XXXXXXX 2013 VDRL 1/4 TPHA 1/ 5120

August 2013- VDRL was negative TPHA was positive. +10240 PL VDRL - FTA ABS - get 3 benzetacil 2.4

Nov 2013 VDRL 1/4 TPHA 1/640

Feb 2014 VDRL 1/4 TPHA 1/1280

May 2014 VDRL 1/8 TPHA 2560

Oct 2014 VDRL 1/4 TPHA- + 1/ 10240 Could you please give your opinion
doctor
Answered by Dr. Johny Chacko (46 minutes later)
Brief Answer:
My opinion on VDRL & TPHA It is unlikely that you have active syphilis

Detailed Answer:
Hello,
Welcome to healthcare magic,
TPHA will remain positive for life if you have had syphilis once in your life time. The titre of TPHA does not matter. It is either positive or negative. VDRL usually becomes negative with complete treatment. In your case you have taken complete treatment more than once. Therefore I feel that your VDRL positivity might be biological false positivity.
Some chronic illness like systemic lupus erythematosus, rheumatoid arthritis or any autoimmune or collagen disease, antiphospholipid syndrome, drug addiction, liver disease, malignancy etc are causes of chronic biological false positivity. Besides many febrile illnesses such as malaria, tuberculosis, filariasis, and conditions such as pregnancy, aging, and immunization might result in transient false positivity.
I feel you should not be worried about having syphilis, but it is a good idea to consult a physician to rule out causes of VDRL Biological false positivity. Physician will do certain blood tests like Complete blood count, Peripheral smear, ANA, RA factor, ANA Profile, liver function tests, Chest Xray, Mantoux test etc for ruling out some common causes of false positivity.
Hope this helped,
Take care.
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
Answered by
Dr.
Dr. Johny Chacko

Dermatologist

Practicing since :2005

Answered : 1916 Questions

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What Does The Following VDRL Test Report Indicate?

Brief Answer: My opinion on VDRL & TPHA It is unlikely that you have active syphilis Detailed Answer: Hello, Welcome to healthcare magic, TPHA will remain positive for life if you have had syphilis once in your life time. The titre of TPHA does not matter. It is either positive or negative. VDRL usually becomes negative with complete treatment. In your case you have taken complete treatment more than once. Therefore I feel that your VDRL positivity might be biological false positivity. Some chronic illness like systemic lupus erythematosus, rheumatoid arthritis or any autoimmune or collagen disease, antiphospholipid syndrome, drug addiction, liver disease, malignancy etc are causes of chronic biological false positivity. Besides many febrile illnesses such as malaria, tuberculosis, filariasis, and conditions such as pregnancy, aging, and immunization might result in transient false positivity. I feel you should not be worried about having syphilis, but it is a good idea to consult a physician to rule out causes of VDRL Biological false positivity. Physician will do certain blood tests like Complete blood count, Peripheral smear, ANA, RA factor, ANA Profile, liver function tests, Chest Xray, Mantoux test etc for ruling out some common causes of false positivity. Hope this helped, Take care.