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What Does My Liver Panel Test Report Indicate?
Question: I Bad a Hepatic Function Panel Serum Test done today and my SGOT came back 168 and my SGPT at 230. 10 dass ago Levels where normal at 15 and 22. Alkaline Phosphatase Double from 68 to 120. just wondering what could cause this. I have a History of Sjogrens and just resently Startes in Imuran.
Brief Answer:
Azathioprine associated liver damage
Detailed Answer:
Hello,
I can understand your concern for abnormal liver functions.
1) Abnormal level of SGPT and SGPT indicate deranged liver function either due to decreased functional capacity of liver cells or presence of high amount of metabolites to processes or appearance of liver disease.
2) History of recent increase in liver enzymes and absence of abdominal symptoms rule out possibility of having liver disease.
3) History of recent initiation of Azathioprine medicine indicate possibility of Azathioprine medicine associated hepatotoxicity. This appear in first few weeks after starting treatment and it is self-limiting condition.
4) Majority of patients are asymptomatic and this can be evident by elevated liver enzymes only.
5) Also, this medicine may cause cholestatic (sluggish flow of bile inside liver) liver damage.
6) It is highly recommended to consult your physician about this issue to consider dose-modification of Azathioprine, if required. Also I would recommend to do LFT periodically to check level of liver enzymes.
Hope I answered your query. If you have any further doubts, I would be happy to help you.
Have a good day!
Azathioprine associated liver damage
Detailed Answer:
Hello,
I can understand your concern for abnormal liver functions.
1) Abnormal level of SGPT and SGPT indicate deranged liver function either due to decreased functional capacity of liver cells or presence of high amount of metabolites to processes or appearance of liver disease.
2) History of recent increase in liver enzymes and absence of abdominal symptoms rule out possibility of having liver disease.
3) History of recent initiation of Azathioprine medicine indicate possibility of Azathioprine medicine associated hepatotoxicity. This appear in first few weeks after starting treatment and it is self-limiting condition.
4) Majority of patients are asymptomatic and this can be evident by elevated liver enzymes only.
5) Also, this medicine may cause cholestatic (sluggish flow of bile inside liver) liver damage.
6) It is highly recommended to consult your physician about this issue to consider dose-modification of Azathioprine, if required. Also I would recommend to do LFT periodically to check level of liver enzymes.
Hope I answered your query. If you have any further doubts, I would be happy to help you.
Have a good day!
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Above answer was peer-reviewed by :
Dr. Nagamani Ng
Answered by
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