Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
188 Doctors are Online

What does my cytometry test result report indicate?

User rating for this question
Answered by

Practicing since : 2004
Answered : 1464 Questions
Hi there,
Wondering if you could interpret some flow cytometry results for me. I am a 27-year-old female who recently underwent lingual tonsillectomy. Initial biopsy done a few weeks prior just showed follicular hyperplasia. I do have a post-op appointment this coming Monday, but would sincerely appreciate a second opinion of sorts.

Here's the report (it wouldn't let me upload):
"Flow cytometric immunophenotyping demonstrates approximately 93% events with CD45/scatter characteristics of lymphocytes. 65% are B lymphoid- type events (CD19 positive), with dim partial CD5 and CD10 coexpression on subset (some nonspecific, dual; CD10 coexpression suggests germinal center cells), and with polyclonal surface immunoglobulin light chain expression overall (kappa: lamda ratio of 1.5), and when specifically analyzed on the CD5 (partial/subset) or CD10 positive subsets. T lymphoid type events (CD3/CD5 positive) comprise 30% with a CD4:CD8 ratio of 5, and no abnormalities of tested T-cell antigen.
The abundantly cellular preparation with numerous small lymphocytes, admixed with rare larger forms, plasma cells histiocytes and squamous cell clusters"

From what I can gather, the T cells look good, but everything regarding the B cells is confusing me. Being a typical patient these days I, of course, try to research everything, and the CD5/CD10 information sounds kind of bad. I want to make sure my surgeon isn't going to blow this off on Monday if it could potentially be something serious. Bacterial culture showed "Few Staphylococcus aureus" and gram stain showed "Many WBC per low power field."

Thank you in advance for any advice/direction you can provide!
Tue, 17 Apr 2018 in Blood Disorders
Answered by Dr. Indranil Ghosh 5 hours later
Brief Answer:
This is just response to infection

Detailed Answer:
Thanks for your query. I understand your concerns.

This report shows predominantly b lymphoid cells, which are polyclonal, admixed with T lymphoid and other cells. The B cells have germinal center phenotype. So everything is suggestive of response to infection, which is pretty much expected in the setting of tonsillitis.

The gram stain and culture reports corroborate this.

So overall, there is nothing to worry in this report.

Hope this helps.
Above answer was peer-reviewed by
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Diseases and Conditions
Medical Procedures
Lab Tests

The user accepted the expert's answer

Ask a Hematologist

© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor