Brief Answer: Better to restart it Detailed Answer: HI Thanks for asking query on healthcare magic. I, Dr Abhishek Kapoor, would try to solve your problem. This condition is called SSRI discontinuation syndrome and this occur following the interruption, dose reduction, or discontinuation of SSRI (selective serotonin re-uptake inhibitor) or SNRI antidepressant medications. The time of onset of symptoms depends upon the elimination half-life of the drug and the patient's metabolism. Withdrawal can be broken into two phases- immediate symptoms, occurring within 6 weeks of discontinuation and less frequently, persistent symptoms that occur months or years after discontinuation. In your case you were on tab Zoloft whose elimination half life is 23 -26 hours. That why you got persistent symptoms. Treatment is dependent on the severity of the discontinuation reaction. In mild symptoms, patient just need assurance, but in cases where further antidepressant treatment is required, then the only step required is restarting the antidepressant. Same thing is in your case. If you are feeling sad and heavy severe persistent withdrawal, then there is nothing harm in restarting it. You can also use Benzodiazepines for insomnia. Rest you can discuss with your treating psychiatrist. I hope with that i would able to solve your query. Regards Dr. Abhishek Kapoor Psychiatrist

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