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What causes severe fatigue, elevated liver enzymes and cyst in lower kidney?

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Posted on Thu, 19 May 2016
Question: Hello, I have been feeling unwell and very fatigued for quite some time now...months. I have been going through many tests and recently my blood work showed high in liver and lymphocyte white blood cells. An ultrasound was done and showed 7x7x5mm complicated cyst in the lower kidney calcified. About 8 months ago I was diagnosed with very high blood pressure and am on Coversyl. I am wondering what all this can mean and if I should be seeing a specialist of some kind.
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Answered by Dr. Luchuo Engelbert Bain (1 hour later)
Brief Answer:
See a Nephrologist. Urgent to esnure kidney function is within normal limit

Detailed Answer:
Hi and thanks for the query,

I understand this could be very disturbing as you rightly put it.

First high liver enzyme tests on its own can be difficult to interpret. It might be a reason not to worry in case the ultrasound you did never revealed any problems or changes in the liver architecture. However, many factors could alter liver function tests like exercise, stress and drugs. I would advice screening for viral hepatitis and running the liver function tests again.

Raised lymphocytes are seen commonly in viral infections. It becomes serious when these remain persistently high or remain excessively high more than 20 000cells/mm3.

My major concern is with the cyst that was seen in the kidney and raised blood pressure. It is imperative for you to seek the opinion of a nephrologist (kidney specialist). Other kidney function tests are required like blood urea and creatinine levels and testing for ions in blood like Sodium, calcium and Potassium. Changes in levels of these hormones, usually seen in kidney disease could partly explain the fatigue. It might of interest to be sure that your hemoglobin levels were ok with your complete blood count, for anemia could also partly explain fatigue.

I strongly advice you book an appointment with a nephrologist. Hypertension of kidney origin must be excluded, especially in your case.

Thanks and kind regards as I wish you the best of health.

Dr Bain


Above answer was peer-reviewed by : Dr. Arnab Banerjee
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Follow up: Dr. Luchuo Engelbert Bain (10 minutes later)
Thank you I appreciate your advice and will see if my doctor will refer me. I don't have a family doctor currently so am just attending a walk in clinic so am concerned about the care I'm receiving.
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Answered by Dr. Luchuo Engelbert Bain (9 hours later)
Brief Answer:
Your walk clinic doctor for sure will refer you.

Detailed Answer:
Hi and thanks for the update,

I understand how disturbing this could be. I think your doctor in the walk clinic hopefully should for sure refer you.

Thanks and kind regards as I wish you the very best of health.

Dr Bain
Above answer was peer-reviewed by : Dr. Prasad
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Answered by
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Dr. Luchuo Engelbert Bain

General & Family Physician

Practicing since :2009

Answered : 3092 Questions

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What causes severe fatigue, elevated liver enzymes and cyst in lower kidney?

Brief Answer: See a Nephrologist. Urgent to esnure kidney function is within normal limit Detailed Answer: Hi and thanks for the query, I understand this could be very disturbing as you rightly put it. First high liver enzyme tests on its own can be difficult to interpret. It might be a reason not to worry in case the ultrasound you did never revealed any problems or changes in the liver architecture. However, many factors could alter liver function tests like exercise, stress and drugs. I would advice screening for viral hepatitis and running the liver function tests again. Raised lymphocytes are seen commonly in viral infections. It becomes serious when these remain persistently high or remain excessively high more than 20 000cells/mm3. My major concern is with the cyst that was seen in the kidney and raised blood pressure. It is imperative for you to seek the opinion of a nephrologist (kidney specialist). Other kidney function tests are required like blood urea and creatinine levels and testing for ions in blood like Sodium, calcium and Potassium. Changes in levels of these hormones, usually seen in kidney disease could partly explain the fatigue. It might of interest to be sure that your hemoglobin levels were ok with your complete blood count, for anemia could also partly explain fatigue. I strongly advice you book an appointment with a nephrologist. Hypertension of kidney origin must be excluded, especially in your case. Thanks and kind regards as I wish you the best of health. Dr Bain