Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

160 Doctors Online
Doctor Image
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

What causes raised DGP-IgG levels in a child?

Answered by
Dr.
Dr. Pradeep Kumar

Pediatrician, Cardiology

Practicing since :2006

Answered : 1946 Questions

default
Posted on Fri, 23 Oct 2015 in Child Health
Question: Hi, are there any other conditions / causes besides celiac disease that can result in high levels of DGP IGG for a little boy. The DGP IGA and TTG IGA and TTG IGG results were all < 1 thank you
doctor
Answered by Dr. Pradeep Kumar 1 hour later
Brief Answer:
Cause other than celiac disease is not well known

Detailed Answer:
Hello

Welcome on HCM

I can understand your concern as this is a very confusing situation even for the physicians.
Anti-dGp IgG is considered to be most sensitive and early marker to detect celiac disease.I went through the literature and research articles after my previous conversation with you.
I found that it is the symptom of celiac disease which is more decision making rather than the test reports in such situations.
According to one large study which included over three thousand children,it has been seen that only Anti-dGp IgG was raised in some of them.In follow up many of them become negative for Anti-dGp over a period of 12-16 months,but those who became symptomatic(diarrhea,indigestion,poor growth,nutritional deficiencies)underwent biopsy and more than 95% of them were suggestive of celiac disease.
So it can be concluded from this and many other studies that although Anti-dGp is highly sensitive test for celiac, there are other causes also which can cause the raised level of dGp,but these are not well described and research is still going on.
There is one condition called IgA deficiency where you can get all other test negative because of low IgA levels.
Haplotype analysis and antiendomysial antibodies if comes positive also gives a clue to the diagnosis.
But the final thing is that whether symptoms of celiac disease are present or not.
So if symptoms appear/persistent consult your physician and discuss for the need of investigations like IgA levels,antiendomysial antibody,haplotype analysis and biopsy.Otherwise keep him in regular follow up with serial anti-dGp assessment.

I hope this helps.
Please let me know if you have any more query.
Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
premium_optimized

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,   ,  
Medical Procedures
Medical Topics

Recent questions on  Iga deficiency

doctor1 MD

Hello, I recently had blood work done and my iga level was 61. They repeated the test along with my other immunoglobulins . They all came back normal including my iga that had raised up to 78 which was in normal range. Can iga levels fluctuate /...

doctor1 MD

THIS IS A REQUEST FOR SECOND OPINION The essentials of my dilemma are these: Long-time allergy/hay fever sufferer. Typically, I respond poorly to non-sedating antihistamines. On occasion, I require antibiotics and oral/injectable steroids. I am...

doctor1 MD

I am IGa deficient. 49 years ago my daughter was born with IGa deficiency. My daughter 53 and son 45 are both normal IGa.



About 40 years ago (I was not aware of IGa) I donated blood. Since I worked in the lab I was aware that the recipient had a reaction to the blood. - The lab went crazy rechecking all availble factors. -



A few years later the same thing happened.



I have not donated blood since but am curious if the IGa could be the cause of these reactions.



I am told to have washed cells only as a recipient but I couldn't have developed anti-bodies.



What is your opinion.



My daughter and one grandaughter would like to know also.



Phyllis Dubey



doctor1 MD

my son age 15 was diagnosed tuesday with IgA deficiency his level is <6 now a month ago it was <7...we were told he would not beable to have blood transfusion if he ever needed one..can he store his own blood in a blood bank or can he..what are the options for blood transfusion..

doctor1 MD

Hello Doctor, My Son has just been diagnosed with CIDP and igA deficiency. I would like information on these types of diseases and what is the best treatment for the diseases he has. He has already lost 85% of the muscles in his
legs and 75% in his hands & arms. He also has started having tremors and is shaking like he is cold but he is not cold.
Thank You, Joanne Love

doctor1 MD

I had a pomeroy tubal 14 years ago. My cycle has run like clockwork every 23 days. My last cycle was 11/12/13. When my cycle was supposed to start I spotted a brown discharge for 2 days. I took a HPT and the first one came out positive. I took a second one and it was negative. I have been having mild cramping, headaches, mild back pain, nausea, bloating, gas and flutters in my belly. I took a progesterone blood test and it was negative. I also have Lupus. Please explain what is going on.