What causes protein in urine?
protein in the urine is a serious finding. Normally there is no protein in the urine. Sometimes some protein can be detected for various reasons, without kidney disease. The protein quantity is very important to know. Various diseases or syndromes may cause protein leakage. In order to find out what caused it a careful review of your medical history, drugs, symptoms and tests is required.
Some important tests to consider include the following:
- 24 hour urine collection for protein.
- antinuclear antibodies (ANA), anti-glomerular basement membrane antibodies (anti-GBM)
- serum protein and albumin
- serum protein electrophoresis
- complete blood count
- erythrocyte sedimentation rate
- urine, creatinine
- urinalysis (including microscopic analysis for sediment)
- kidney ultrasound scan
These are some very basic tests. Depending on the findings, other tests might be considered.
Let me add a few words about some fairly common benign conditions with protein in the urinalysis.
- too dense urine (specific gravity close to 1030) may cause detection of protein.
- urinary tract infection
- orthostatic proteinuria, which means that protein is excreted in the urine when the patient is physically active but not during rest.
Depending on the final diagnosis, the prognosis may be great or pretty bad. Being swollen probably means that your albumin levels in the serum are low, which probably means that you're loosing too much protein in the urine or it could mean a faulty kidney function and fluid retention.
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you'd better check this as soon as possible
I don't know if you've already checked that, but dark urine and decreased quantity of urine may be caused by muscular damage (rhabdomyolysis). When too much myoglobin enters the urine, the urine turn red (like if there's blood) and the kidneys are in danger. The serum CPK levels may be very high. In cases like this, it's common for the patient to experience back pain. Lasix won't help much if low albumin caused the swelling.
Rhabdomyolysis is treated by increased urinary flow. In the most serious cases, intravenous fluids are administered. The serum potassium may be abnormal.
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