Brief Answer: Nexium gives positive urine drug screen... Detailed Answer: Hi, The drugs you are taking (rocephin shot, decadron shot, mucinex, and Claritin) do not cause positive drug screen. Unless you are using a combination form of mucinex with pseudoephedrine, then, the urine drug screen will result positive. You are reporting to be using Nexium for ulcer, which belongs to the drug class named proton pump inhibitors. There are reported cases of positive urine drug screen for such drugs. Please bare in mind that there are 2 main drug tests: 1) screening - immunoassay tests 2) confirmation tests - GC/MS If the screening test will result positive, you can ask to sent your urine specimen for confirmation tests, where it will be reported as negative. In fact, this kind of test eliminates problems related to false positive results. Hope it helped! Let me know if you have further queries! Dr.Albana

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