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What causes myelodysplastic syndromes while suffering from CLL?

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Posted on Fri, 13 May 2016
Question: What are the chances, what is the relationship even, of having MDS develop out of CLL.?
My wife has the chronic lymphacytic leukemia, with some suspicion of the myeloid dysplastic syndrome, which as I understand, CAN/or DOES turn into ALL…which is fatal. Whereas the CLL is pretty much a lifelong pain in the ass, but not what kills you. This is pretty advanced stuff..we're in a clinical trial at Ohio State w one of the country's best leukemia oncologists… and he says he doesn't THINK she has the MDS, or if she does, it's very early stages…too early to tell, I guess. But it's in the back of my mind all the time, like, whenever I look at her. You can imagine. So….you know anything about all that?
I'd be astounded if you did, and answered. ! And thanks for your attention anyway. XXXXXXX
YYYY@YYYY
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Answered by Dr. Hardik Sanghvi (4 hours later)
Brief Answer:
It depends on treatment.

Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.
She has CLL. It is chronic lymphocytic leukemia. It is very slow growing leukemia with best prognosis. Chances of MDS from CLL is not common.

But chemotherapy induced changes also contribute.
In MDS there is pancytopenia. Means all cells are decreased in number. It can be easily distinguished by routine complete blood count and peripheral smear examination.

Don't worry much about that. Send me her last complete blood count report. so that I can help you further.

Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Hardik Sanghvi

Hematologist

Practicing since :2008

Answered : 7040 Questions

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What causes myelodysplastic syndromes while suffering from CLL?

Brief Answer: It depends on treatment. Detailed Answer: Hi, dear I have gone through your question. I can understand your concern. She has CLL. It is chronic lymphocytic leukemia. It is very slow growing leukemia with best prognosis. Chances of MDS from CLL is not common. But chemotherapy induced changes also contribute. In MDS there is pancytopenia. Means all cells are decreased in number. It can be easily distinguished by routine complete blood count and peripheral smear examination. Don't worry much about that. Send me her last complete blood count report. so that I can help you further. Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using health care magic. Wish you a very good health.