What causes inflammation around cancer tissues?

Posted on Sat, 29 Aug 2015 in Cancer
Question: Academic question.
If there is inhibition of T cell activation in cancer how do you explain why there is often inflammation in the surrounding tissues, eg esophageal cancer.
Answered by Dr. Indranil Ghosh 1 hour later
Brief Answer:
There are many pathways going on

Detailed Answer:
Thanks for your query.

In tumor microenvironment there are many cells and pathways going on. On one hand there are Treg cells which inhibit immunity/inflammation. On another hand are proinflammatory cells and helper T cells. The balance determines the level of inflammation and prognosis.

In general, infiltrating tumor lymphocytes are dissociated with better prognosis in cancer.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
Answered by
Dr. Indranil Ghosh


Practicing since :2004

Answered : 1495 Questions


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