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What causes increase in thyroid antibodies in my thyroid test report?

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Posted on Tue, 24 Mar 2015
Question: How does a number like 37 compare to the normal range for Thyroid antibodies...order of magnitude outside of it included. What are the most likely diagnosis suggested....or at least things that should be considered first. How can genetics impact this number? And, if vitamin D is low, is that another related indicator?
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Answered by Dr. Shehzad Topiwala (27 minutes later)
Brief Answer:
Thyroid

Detailed Answer:
In order for me to comment on the value of 37, I need to know couple things first ; a) are these anti TPO ( thyroid peroxidase ) antibodies or anti thyroglobulin antibodies b) what is the laboratory range specified on your report for this test result of 37? To elaborate, there are two types of thyroid autoantibodies as mentioned above and they both have different normal ranges. Moreover, the normal range friends on the method used ie there are more than one test techniques ('assay') to run these tests and so the normal range can be very different for the same test from lab to lab. The order of magnitude also varies by the same token. Furthermore there is not much to be gained by interpreting antibody levels. Just the fact that they are positive is enough evidence to suggest that your thyroid is being attached by your own immune system. Such medical conditions are referred to as Auto immune diseases. What you likely have , provided your value of 37 is above the normal range for that particular lab, is Hashimoto's thyroiditis especially considering the condition runs in your family. Regarding the role of genetics the answer is yes that there is a tendency for this condition to affect family members and particularly females. Low vitamin
D is an independent condition that is not known to be related directly to this thyroid problem
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Shehzad Topiwala

Endocrinologist

Practicing since :2001

Answered : 1663 Questions

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What causes increase in thyroid antibodies in my thyroid test report?

Brief Answer: Thyroid Detailed Answer: In order for me to comment on the value of 37, I need to know couple things first ; a) are these anti TPO ( thyroid peroxidase ) antibodies or anti thyroglobulin antibodies b) what is the laboratory range specified on your report for this test result of 37? To elaborate, there are two types of thyroid autoantibodies as mentioned above and they both have different normal ranges. Moreover, the normal range friends on the method used ie there are more than one test techniques ('assay') to run these tests and so the normal range can be very different for the same test from lab to lab. The order of magnitude also varies by the same token. Furthermore there is not much to be gained by interpreting antibody levels. Just the fact that they are positive is enough evidence to suggest that your thyroid is being attached by your own immune system. Such medical conditions are referred to as Auto immune diseases. What you likely have , provided your value of 37 is above the normal range for that particular lab, is Hashimoto's thyroiditis especially considering the condition runs in your family. Regarding the role of genetics the answer is yes that there is a tendency for this condition to affect family members and particularly females. Low vitamin D is an independent condition that is not known to be related directly to this thyroid problem