What causes elevated blood sugar level while on blood-glucose lowering medicine?
She has been following a sensible (low-carb/sugar) diet as well.
She currently takes trileptal, myfortic & tacrilmus. She is a recipeant of a donated kidney (3 years).
Diabetes can be complex to analyze many a times.
It is a complicated interplay of a myriad factors such as
Stage of disease
Effects of other medications
These are only a few examples.
In your wife's case, the other medications she is on, are likely playing a role. Tacrolimus is very well known to raise blood glucose levels. There are reports of myfortic and trileptal being capable of the same.
Now oyur question is why the sugars are rising depsite medication dose increases.
As explained, there can be one or more of the above mentioned factors playing into this.
Moreover, there is a 20% variation in the meter readings compared to the real blood glucose values. So if your blood glucose (if it were taken from a blood sample from your veins, as in a laboratory blood draw) is 100, the meter may show anything between 80 to 120.
So it is best to not analyze such variations in readings from a monitoring device. It has it's limitations.
Rather, it is important to go by broad trends in the sugar values. So if it is persistently climbing, say for example over 200 and 250 for a few days then it is a worrisome pattern.
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