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What causes elevated alkaline phosphatase levels in blood?

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Posted on Thu, 3 Dec 2015
Question: My ALK level rapidly went from 203 to 531,now Doctors are going to a biopsy very scared.I don't know how high it has to get to indicate severe problems.Other liver test have also been abnormal just not to this extreme? Thank you.
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Answered by Dr. Shafi Ullah Khan (4 hours later)
Brief Answer:
Need work up and a complete clinical correlation

Detailed Answer:
Thank you for asking

I read your question and i understand your concern. Your Alkaline phosphatase levels are threefold of normal and likely indicate some extrahepatic biliary obstruction like stone, cholecystitis etc. Simultaneous increased levels of GGT (Gamma Glutamyl Transferase) will make it more likely. Other possibilities like paget's disease, osteoporosis, primary and secondary hyperparathyroidism etc should be ruled out too

Malignancies causing increased Alkaline phosphatase but that is mostly in heads of pancreas. Lets wait for the biopsy report and see what comes up.

I hope it helps. take good care of yourself and dont forget to close the discussion please.

Regards
Khan
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Shafi Ullah Khan

General & Family Physician

Practicing since :2012

Answered : 3613 Questions

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What causes elevated alkaline phosphatase levels in blood?

Brief Answer: Need work up and a complete clinical correlation Detailed Answer: Thank you for asking I read your question and i understand your concern. Your Alkaline phosphatase levels are threefold of normal and likely indicate some extrahepatic biliary obstruction like stone, cholecystitis etc. Simultaneous increased levels of GGT (Gamma Glutamyl Transferase) will make it more likely. Other possibilities like paget's disease, osteoporosis, primary and secondary hyperparathyroidism etc should be ruled out too Malignancies causing increased Alkaline phosphatase but that is mostly in heads of pancreas. Lets wait for the biopsy report and see what comes up. I hope it helps. take good care of yourself and dont forget to close the discussion please. Regards Khan