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What causes drowsiness after taking Trazodone?

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Posted on Mon, 25 Jul 2016
Question: Serum digotin or phenytoin levels. I was taken 300 mg of Trazodone and it made me sleep drive and I woke up in jail the next morning.

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Answered by Dr. Matt Wachsman (29 minutes later)
Brief Answer:
Drug levels are often helpful.

Detailed Answer:
Sadly, I think you are going to be guilty.

Note that none of these are addictive, controlled, nor abused drugs. Furthermore, while on the high side, 300 mg trazodone is a commonly prescribed usual dose. While I cannot say in your particular case wtihhout being there, examining, you, etc, the sitaution described would be someone taking their prescribed drugs at their prescribed doses and not doing anything wrong. But still, driving under the influence includes regular medications used correctly. Certainly the person in jail would want to show that they had no drugs of abuse in their system and a urine or hair analysis is best for that. Blood levels of all medications may be useful BUT the level in the blood rapidly declines for most medications including the ones mentioned. FOr this reason, blood levels 24 hrs after the incident won't necessarily be helpful.

There is another issue in that people on dilantin are generally epileptic and driving in these people is dangerous and needs to be approved by a physiician.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Matt Wachsman (3 hours later)
I was also on amitriptyline 25 mg, Wellbutrin, Xanax, Oxycodone, Topamax, Gap, Paxil, Mobic, I drug test every 2 months at my pain dr. All my doctor said I should have been taken to the hospital. I don't remember anything. But thinks
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Answered by Dr. Matt Wachsman (3 hours later)
Brief Answer:
that is a lot of drugs.

Detailed Answer:
Trazodone, paxil, amitryptiline, and welbutin are all antidepressants.

Putting all of them together causes the chemical they all increase in the brain (serotonin) to increase to the point where it causes problems
https://www.yyy.yyyy.yyy/yyyyyy/ency/yyyyyy/007272.htm
This is called serotonin syndrome. It doesn't show up on drug tests. If there were other symptoms when you came around (diarrhea and flushed feeling being the most common) then it would imply serotonin syndrome.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Matt Wachsman

Addiction Medicine Specialist

Practicing since :1985

Answered : 4201 Questions

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What causes drowsiness after taking Trazodone?

Brief Answer: Drug levels are often helpful. Detailed Answer: Sadly, I think you are going to be guilty. Note that none of these are addictive, controlled, nor abused drugs. Furthermore, while on the high side, 300 mg trazodone is a commonly prescribed usual dose. While I cannot say in your particular case wtihhout being there, examining, you, etc, the sitaution described would be someone taking their prescribed drugs at their prescribed doses and not doing anything wrong. But still, driving under the influence includes regular medications used correctly. Certainly the person in jail would want to show that they had no drugs of abuse in their system and a urine or hair analysis is best for that. Blood levels of all medications may be useful BUT the level in the blood rapidly declines for most medications including the ones mentioned. FOr this reason, blood levels 24 hrs after the incident won't necessarily be helpful. There is another issue in that people on dilantin are generally epileptic and driving in these people is dangerous and needs to be approved by a physiician.