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What causes depression symptoms despite taking anti-depressants?

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Posted on Fri, 20 May 2016
Question: unfortunately your answer isn't any different than what my doctor and psychiatrist already told me except for that those symptoms can be caused by depression they have done all the tests that rule all of those that you said could cause these problems. So if I am on all these antidepressants why am I having these symptoms?
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Answered by Dr. Seikhoo Bishnoi (1 hour later)
Brief Answer:
Resistant depression can be managed.

Detailed Answer:
Hello again, thanks for asking again

What type of antidepressants you are taking?

Some times even while on antidepressants individuals fail to respond and this results in resistant depression. Associated hypothyroidism, vitamin B12 deficiencies are commonly seen in such patients. If you haven't undergone these tests then go for these tests.

Addition of Vitamin B12 (Methylcobalamine especially) to conventional prescription results in better response to medicines. Augmentation of therapy with drugs like Bupropion, Lithium has shown to greatly effective in poor responders. This will result in quick recovery.

I'd advise you to take Omega-3-Fatty Acid supplements which also helps a lot in depression. These are available with most of chemists. These also increase the response of other medicines.

Thanks. Hope this helps. Still have doubts please ask again.

Take care
Above answer was peer-reviewed by : Dr. Yogesh D
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Follow up: Dr. Seikhoo Bishnoi (22 minutes later)
I am taking Abilify 7 mg and 60 mg Fluoxetine as well as 1mg of clonazepam everyday, I have been on these meds for years should i be talking to my doctor about a medication review?
doctor
Answered by Dr. Seikhoo Bishnoi (1 hour later)
Brief Answer:
Yes the medicines should be reviewed.

Detailed Answer:
Hello again and thanks for asking a follow up

Abilify is Aripiprazole and the drug is an antipsychotic mood stabiliser drug. Fluoxetine is an antidepressant. If these drugs are not working then either the drugs should be changed or should be augmented with some other drug.

Amisulpiride can be used in low doses in place of Abilify and this will help to lift your mood and you will feel better. The drug is safe and helps to increase the antidepressants actions. Other option is to replace the Fluoxetine with some other antidepressant preferably with a SNRI drug. Venlafaxine is better choice and this drug helps a lot in moderate to severe depression. You can discuss with your doctor for either of these drugs.

Thanks, Hope this helps. Please don't hesitate to ask again for more uncleared doubts.
Above answer was peer-reviewed by : Dr. Yogesh D
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Answered by
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Dr. Seikhoo Bishnoi

Psychiatrist

Practicing since :2007

Answered : 5187 Questions

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What causes depression symptoms despite taking anti-depressants?

Brief Answer: Resistant depression can be managed. Detailed Answer: Hello again, thanks for asking again What type of antidepressants you are taking? Some times even while on antidepressants individuals fail to respond and this results in resistant depression. Associated hypothyroidism, vitamin B12 deficiencies are commonly seen in such patients. If you haven't undergone these tests then go for these tests. Addition of Vitamin B12 (Methylcobalamine especially) to conventional prescription results in better response to medicines. Augmentation of therapy with drugs like Bupropion, Lithium has shown to greatly effective in poor responders. This will result in quick recovery. I'd advise you to take Omega-3-Fatty Acid supplements which also helps a lot in depression. These are available with most of chemists. These also increase the response of other medicines. Thanks. Hope this helps. Still have doubts please ask again. Take care