Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

129 Doctors Online
Doctor Image
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

What causes cramping and continuous periods while on Depo-Provera or Mirena IUD?

Answered by
Dr. Aarti Abraham


Practicing since :1998

Answered : 6011 Questions

Posted on Mon, 14 May 2018 in Women's Health
Question: Hello, my 18 year old daughter has been having HORRIBLE female problems. Within the last year she has been on Deproprevara, exploratory endometriosis surgery and then switched to Mirena IUD. Last week she switched to a new OBGYN and he put her on NuvaRing. She is at college and called me late last night because she feels extremely depressed and had spent hours crying for no reason. She has taken the ring out, but doesn’t feel that she has any options left. She had continuous periods and constant cramping on regular birth control, the Depo and Mirena. Help!
Answered by Dr. Aarti Abraham 3 hours later
Brief Answer:
As below

Detailed Answer:
Thanks for trusting us with your health concern.
It sounds like she has severe endometriosis.
She can consider Lupride ( leuprolide ) shot or danazol oral medication.
Alternatively, Seasonale birth control that would have her menstruate only once in 3 months is a good option.
Please provide me with her medical history records and imaging details so that I can assess the severity of her condition.
Looking forward to hearing from you.
Take care.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
Follow up: Dr. Aarti Abraham 2 hours later
She started her period when she was 11 and immediately had heavy flow with severe cramps and was put on oral birth control. She was fine until September of 2016 when she presented with severe cramping and heavy and constant breakthrough bleeding. Her OBGYN put her on Depro-Prevera shots every 3 months. After 6 months she was having breakthrough bleeding and cramping again so the doctor changed her to every 2 months. Late Spring 2017, she still had spotting and cramping so her doctor recommended a CT with contrast, which showed "cloudy spots" so she had exploratory laparoscopic surgery to look for endometriosis but it did not show any adhesions. Her ovaries and fallopian tubes were clear and healthy. September of 2017 she was put on Mirena IUD and after 3 months, nothing had changed. Her OBGYN basically gave up on her so she saw a new OBGYN last week. He put her on NuvaRing and after a week, she has been severely depressed...crying for no reason. Yesterday, she removed the NuvaRing and reported this afternoon that she was already feeling much better.
Answered by Dr. Aarti Abraham 21 hours later
Brief Answer:
As below

Detailed Answer:
Thank you for the details.
I am still not clear whether she has a diagnosis of Endometriosis or not.
There were no adhesions, but was it diagnosed as Endometriosis?
If not what is her diagnosis post the CT, imaging and the surgery?
From what you tell me, the Nuvaring and Mirena have not suited her.
Is the Mirena out?
Has she remained absolutely hormone free recently to see how bad her symptoms are?
And yes, if there is no obvious pathology, this could be plain puberty menorrhagia which will settle down.
Has she been investigated for associated possibly contributory medical conditions such as diabetes, hypothyroidism,anemia, bleeding disorders?
A hormone free interval with just plain tranexamic acid to control heavy bleeding should be tried in there is no identifiable pathology.
Waiting to here more.
Take care
Above answer was peer-reviewed by : Dr. Raju A.T

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,  
Drug/Medication ,   ,  
Medical Procedures
Medical Topics ,  

Recent questions on  Lupride

doctor1 MD

Hi doctor, Im 30 year old female married for 5 years. Trying to concieve our first baby. Husband works abroad so we are together on and off. Tried normally but could not get pregnant so doctor suggested iui. Had hsg XXXXXXX test in july and both...

doctor1 MD

Hi doctor Iam 28yrs old having PCOS I had an abortion a year back. We are TTC from 3 months last month my follicular study said egg size was19mm endo as 12mm and I was given luproid injection and duphaston in first cycle still I dint conceive...

doctor1 MD

Is there any relation between Lupride injection and TSH levels being increased?
I am 35yrs old, 5.7ft ht, 81Kgs wt. I have PCO, cornual block in 1 tube and had 3-4 failed attempts of IUI.
I would undergo ivf next month, n so doc put me on Lupride injection in preparation for the next cycle.
When I did the test of TSH, my results were out of range with 11.31. I take thyroxin 25mg daily. Earlier when I had done this test in January this yr, it was normal.

So, wanted to know if the Lupride injection had some effect on my TSH and also will it be a problem if I have elevated TSH levels during IVF???

doctor1 MD

Hi Doc, we were planning for IVF as one of my tube was blocked. So in the initial phase of it I was on Lupride injection from my 14th day of period. My
I didn't got my obgyn has asked me to visit on the 3rd day of my next period. Surprisingly I didn't got my period and after a week delay I visited her. She did sonography and prescribed 5 days pills to get the period. I was in a dilemma and didn't took those medicine. Yesterday after 10 days of my period delay, I went to her and she did sonography again and asked to take those pills to get period but for my satisfaction she asked for the pregnancy test. Surprisingly it was positive. Now I am really not sure how to trust my obgyn coz had I taken those pills, I would have aborted. She is a very senior Doc for IVF. After this she has prescribed Naturogest 200mg thru Vagina twice a day as my earlier test of hormones was 0.8 level which is considered to be very low. Please advise can I continue with Naturogest and Folvite? Also I need to take weekly two injections of Karagon (5000 IU) for first 3 months. Is this safe?

doctor1 MD

i m 34 years old, had a laproscopy on 30.08.13 and was diagnosed with endometriosis. was given Lupride injection. After 2 months my FSH-7.2, LH-2.7 and AMH-1.12. in the November cycle-had Siphene tablets for 5 days, Humog injection on day 5 & 7. Had injection Decepeptyl 0.1 mg on day 11. There were 3 follicles in the right ovary and 2 in the left. on the 15th day only one follicle have busted. 2 follicles have become cysts. please help

doctor1 MD

I m 34 yrs. old and has been diagnosed with proliferative endometrium cyst . We have already done RT. overian cyst operation on 2 and 1/2 month before. now the cyst has been diagnosed on left overy. our dr. has given a luprid inj. 3.75 mg and told us surgery not need now. could you please help us and confirm,the cyst will dissolve with medication?Cyst is approx. 91mm.