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What Causes Abdominal Pain, Fatigue, Insomnia And Depression When Diagnosed With Hypergammaglobulinemia?

Posted on Sat, 6 Aug 2016

Question: I tested positive twice for polyclonal hypergammaglobulinemia. Could that be what is causing all my symptoms? What other blood tests should be performed to determine a diagnosis?

Answered by Dr. Hardik Sanghvi (48 minutes later)

Brief Answer:
Please tell me about your symptoms.

Detailed Answer:
Hi, dear
I have gone through your question.
I can understand your concern.
You are tested positive for hypergammaglobulinemia.
But please tell me about your symptoms so that I can tell you whether it is due to hypergamma globulinemia or some other cause. And tests you required.

Common symptoms are pain, insomnia, fatigue, weakness, anxious and depressed mood etc.
Symptoms of associated liver disease or connective tissue disease can be there.

So provide me your symptoms.

Thanks for using health care magic.
Wish you a very good health.

Above answer was peer-reviewed by : Dr. Veerisetty Shyamkumar

Follow up: Dr. Hardik Sanghvi (11 hours later)

I have abdominal pain, chest pain, and headache. It is so debilitating I couldn't function.

symptoms

feels like my blood is being poisoned
headache that makes me barely able to open my eyes
chest pain fast heart rate
stomach tightening pain
stomach cramps
loose tissue on chest
no appetite
resolves at night, intense at daytime
easily get startled
sensitive to pain and distress
sensitive to medicine
weight loss from 170 lbs in nov 2014 to 140 lbs in jun 2016
twitching eyes
ground moves constantly
tired and anxious
heart rate always high 90-164 bpm
feels like something is pushing down on my head
dizzy
gets tired easily
sensitive to medicine
sensitive to sound
gets easily startled
bloody stools

Answered by Dr. Hardik Sanghvi (16 hours later)

Brief Answer:
Hyperviscosity and anxiety disorder symptoms.

Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.

Your most of the symptoms are due to hyper viscosity caused by polyclonal gamma globulinemia. You also have some issues related to anxiety. So symptoms are aggravated.

For anxiety disorder you should consult psychiatrist.

For hyper gamma globulinemia you should search the cause for it and take treatment accordingly.

You should go for complete blood count, liver function test, ANA by IIF. This will help you to find the primary cause of hyper gamma globulinemia.

Plasmapheresis and steroids are helpful.

Consult your doctor and plan accordingly.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Hardik Sanghvi (17 hours later)

I already consulted my doctors and they cannot find where the inflamation is. They cannot determine a diagnosis. I attached my hospital record maybe you can help me.

Answered by Dr. Hardik Sanghvi (5 hours later)

Brief Answer:
Detailed answer given below.

Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.

I have gone through your all reporta and record. You already have gone through many investigations.

Your ESR is slightly high.
Your liver function test is normal. Your ANA test is also normal. You don't have any malignancy in major organs. Rest all other investigations are also normal.

So its very difficult to search the cause of hyper gamma globulinemia.

But still you should take steroids to reduce inflammation.

If still you have symptoms of hyper viscosity then go for plasmapheresis.

Take treatment of your anxiety disorder according to advise of psychiatrist.

Hope I have answered your question. If you have any doubts then feel free to ask me. I will be happy to answer.
Thanks for using health care magic.
Wish you a very good health.

Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar