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What Are The Toxic Effects Of Overdosed Restly O.5mg Tablets?

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Posted on Mon, 8 Dec 2014
Question: Hi Doctor, One of friend has taken 25 restly .5 tab. Will that cause any harm to her.
doctor
Answered by Dr. Suresh Heijebu (1 hour later)
Brief Answer:
Can cause Cardiorespiratory depression

Detailed Answer:
Hi. Sir.

I understand your concern.

25 tabs of alprazolam 0.5 mg each would mount to 12.5mg which is 50 times the lowest dose advised therapeutically.

Definitely it can cause toxic effects like excessive sedation,respiratory center depression,low blood pressure.

The blood values in the range of 300-2000 mcg/l can prove lethal.

Thank you.
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
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Follow up: Dr. Suresh Heijebu (2 hours later)
Thank u so much sir, hope there is no problem for her life.
And also she is now pregnant with 3rd month.
doctor
Answered by Dr. Suresh Heijebu (1 hour later)
Brief Answer:
My best wishes to your friend.

Detailed Answer:
Hi,Sir

Pregnancy can worsen the toxicity of alprazolam. I hope she has seen a doctor and is being monitored by the doctor.

My best prayers and wishes to your friend.

Thank you.
Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. Suresh Heijebu (2 hours later)
Sir Thank u so much for ur ans. But i dint undstood ur ans. Can u plz explain briefly. Is there any problem to her life.
Or will it harm baby in stomach.

I hope she has been taken to hospital. I dint got any update frm my other friends. I just got dis news dat she has taken pills. Am in other place trying to knw what happens in dis case.

doctor
Answered by Dr. Suresh Heijebu (14 minutes later)
Brief Answer:
Alprazolam will affect both mother and baby.Intensive care monitoring is needed.

Detailed Answer:
Hi Sir,

I mean it will affect both the mother and the baby.

Pregnancy can increase the dangers of alprazolam ingestion. In this case a cautious approach towards the patient is a basic rule. Both the health of the mother and the baby has to dealt separately.

Management in an intensive acute medical care unit is the basic prerequisite here.

Since the ingested dose of alprazolam is quite high about 25 tablets, its advisable to have a baseline blood alprazolam levels. The definitive management would be is to place the patient on a ventilator to improve the oxygen status and arrest the progression of the respiratory depression. The vital parameters like blood pressure and oxygen saturation has to be normalised.

Simultaneously the baby's health should be assessed through non stress tests and biophysical profile scoring. Hemodialysis in the mother can largely remove the toxic products of alprazolam and improve the health condition.

In all such cases expert management in a tertiary health care center under the guidance of critical care specialist ,obstetrician and a cardiologist has to be followed. Expert medical scrutiny is needed for the next 48-72 hours to assess the overall final prognosis .

Management of such cases at home is not advisable. Therefore if your friend is not hospitalised, I recommend she gets shifted immediately to a high dependancy units at sophisticated centers.

Keep in touch with your friends and track her health status and post your further queries,if any.

Thank you
Note: For further follow-up it is advisable to consult an emergency medicine specialist. Click here.

Above answer was peer-reviewed by : Dr. Prasad
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Answered by
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Dr. Suresh Heijebu

Psychiatrist

Practicing since :2010

Answered : 3646 Questions

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What Are The Toxic Effects Of Overdosed Restly O.5mg Tablets?

Brief Answer: Can cause Cardiorespiratory depression Detailed Answer: Hi. Sir. I understand your concern. 25 tabs of alprazolam 0.5 mg each would mount to 12.5mg which is 50 times the lowest dose advised therapeutically. Definitely it can cause toxic effects like excessive sedation,respiratory center depression,low blood pressure. The blood values in the range of 300-2000 mcg/l can prove lethal. Thank you.