Brief Answer:
Side effects include weight gain, gastritis etc

Detailed Answer:
Hi XXXX,

Welcome to HCM. I have gone through your questions and understand your concerns.

Yhe common side effects seen with these medications other than low sugars are

1 Glyburide:

Giddiness, rash, weight gain, breathing difficulties etc

2. Metformin:

Abdominal pain, gastritis, diarrhoea, decreased appetite, anaemia, muscle pain etc

3. Insulin:

Allergic reactions, weight gain, local skin problems etc

Hope I have answered your questions. If you have any further queries I will be happy to help you.

Regards,

Dr Ajish TP [MD,DM]
Consultant Endocrinologist

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Brief Answer:
There is no added risk when used in combination

Detailed Answer:
Hi XXXX,

There is no other added risk other than hypoglycaemia when these drugs are used in combination.

Glyburide is not a safe drug from cardiac point. Metformin won't cause kidney problems , but if you have kidney problems due to diabetes we cannot continue Metformin as side effects like lactic acidosis increases.

If you are using basal insulin ( NPH or Glargine or detemir) there rationale in taking it with Glyburide and Metformin. But if you are taking twice daily pre mixed insulin it is recommended to stop Glyburide.

Hope this information was useful to you.

Regards
Dr Ajish TP

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