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What Are The Side Effects Of Prednisone, Prograf And Cellcept?

Posted on Thu, 13 Mar 2014

Question: I have had a renal transplant for 12 years. I am taking prednisone, prograf and cellcept for anti-rejection. I have recently developed interstitial fibrosis in the lower lobes of my lungs. My pulmonary Doc and my Oncologist think one of the drugs may be causing this development. Have you ever heard of this side effect for any of those drugs?

Answered by Dr. Shanthi E (5 hours later)

Brief Answer: cellcept is likely cause Detailed Answer: Hello, I have read your concerns. Yes, Cellcept or Mycophenolate mofetal can cause interstitial fibrosis as a side effect. In fact, interstitial fibrosis of the lung is one of the potentially fatal adverse effects of the drug. Prograf or Tacrolimus can rarely cause interstitial fibrosis. There are hardly any studies to prove the same. Hence, both your pulmonary and oncology doctors are right in their interpretation. This side effect is more common with Cellcept than Prograf. Hope this information helps you. Regards,

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Shanthi E (17 hours later)

Just to say THANK YOU very much...bad news for me, but a straight answer. XXXXXXX

Answered by Dr. Shanthi E (16 minutes later)

Brief Answer: always weight risk benefit ratio Detailed Answer: Hello XXXXXXX Thank you too. Your doctor would always weigh the risk-benefit ratio of using any drug in you. So, you must go along with what your treating doctor does. Take care!

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar