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What are the long term side effects of Enbrel injection?

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Posted on Fri, 24 Aug 2018
Question:
One of my family friends is suffering from Ankylosing Spondylitis, the doctor has advised with treatment of s/c injection of Enbrel weekly for 6 months.
Please advise on the effective outcome of this treatment & any side effects .
Does he need to get admitted in the hospital for this treatment.



doctor
Answered by Dr. Praveen Tayal (27 minutes later)
Brief Answer:
Detail below.

Detailed Answer:
Hello,

Thanks for posting your query.
Enbrel is etanercept,it is a biological medicine which is used for treating inflammatory conditions such as rheumatoid arthritis and ankylosing spondylitis. Intacept Injection blocks the TNF (tumor necrosis factor alpha) that causes inflammation.
Etanercept works by decreasing a certain protein produced by the immune system. The immune system helps the body fight infections. In people with autoimmune disorders, the immune system mistakes the body's own cells for invaders and attacks them.
This is very effective treatment.
The drug is especially dangerous for people with chickenpox. It can also lead to nervous system problems such as sclerosis and seizures. It can also weaken the heart and lead to heart problems. It should be avoided by people who are allergic to latex, are pregnant or are planning to do so, have been in close proximity to a person with chicken pox.
fever, night sweats, weight loss, tiredness;
feeling full after eating only a small amount;
pain in your upper stomach that may spread to your shoulder;
easy bruising or bleeding, pale skin, feeling light-headed or short of breath, rapid heart rate; or
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Stop using etanercept and call your doctor at once if you have any of these other serious side effects:

signs of infection (fever, chills, sore throat, body aches, confusion, neck stiffness, flu symptoms);
shortness of breath with swelling, rapid weight gain;
chest pain, ongoing cough, coughing up mucus or blood;
signs of skin infection such as itching, swelling, warmth, redness, or oozing;
black, bloody, or tarry stools;
changes in mood or personality (in children);
numbness, burning, pain, or tingly feeling;


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Enbrel Patient Information Including Side Effects
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Moderate to Severe Forms of Psoriasis Slideshow

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Brand Names: Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick
Generic Name: etanercept (Pronunciation: ee XXXXXXX er sept)

What is etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?
What are the possible side effects of etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?
What is the most important information I should know about etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?
What should I discuss with my healthcare provider before using etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?
How should I use etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?
What happens if I miss a dose (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?
What happens if I overdose (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?
What should I avoid while using etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?
What other drugs will affect etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?
Where can I get more information?

What is etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?

Etanercept works by decreasing a certain protein produced by the immune system. The immune system helps the body fight infections. In people with autoimmune disorders, the immune system mistakes the body's own cells for invaders and attacks them.

Etanercept is used to treat the symptoms of rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis, and to prevent joint damage caused by these conditions. It is also used to treat plaque psoriasis in adults and polyarticular juvenile idiopathic arthritis in children who are at least 2 years old.

Etanercept may also be used for purposes not listed in this medication guide.

What are the possible side effects of etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using etanercept and call your doctor right away if you have any of these symptoms of lymphoma:

fever, night sweats, weight loss, tiredness;
feeling full after eating only a small amount;
pain in your upper stomach that may spread to your shoulder;
easy bruising or bleeding, pale skin, feeling light-headed or short of breath, rapid heart rate; or
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Stop using etanercept and call your doctor at once if you have any of these other serious side effects:

signs of infection (fever, chills, sore throat, body aches, confusion, neck stiffness, flu symptoms);
shortness of breath with swelling, rapid weight gain;
chest pain, ongoing cough, coughing up mucus or blood;
signs of skin infection such as itching, swelling, warmth, redness, or oozing;
black, bloody, or tarry stools;
changes in mood or personality (in children);
numbness, burning, pain, or tingly feeling;
joint pain or swelling with fever, swollen glands, muscle aches, chest pain, unusual thoughts or behavior, and/or seizure (convulsions); or
patchy skin color, red spots, or a butterfly-shaped skin rash over your cheeks and nose (worsens in sunlight).

Less serious side effects may include:

mild nausea, vomiting, mild diarrhea, mild stomach pain;
runny or stuffy nose, cold symptoms; or
headache.
I hope this answers your query.
In case you have additional questions or doubts, you can forward them to me, and I shall be glad to help you out.


Hope I have answered your query.
Let me know if I can assist you further.


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Praveen Tayal (2 hours later)
Dear Doctor,
Thanks for the reply
However this a very detailed explanation

We would like to know if there is any requirement for him to be hospitalised for taking injection Enbrel.
doctor
Answered by Dr. Praveen Tayal (2 hours later)
Brief Answer:
No.

Detailed Answer:
Hello.


There are also several ways for patients to self-administer ENBREL after receiving training from healthcare providers.
Prior to self-administration, patients should receive injection training from a health care professional and refer to the Instructions for Use. ... The AutoTouch device should be requested through your rep (once per patient).

Take Care!
Dr. Praveen Tayal,
Orthopaedic Surgeon
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Praveen Tayal

Orthopaedic Surgeon

Practicing since :1994

Answered : 4874 Questions

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What are the long term side effects of Enbrel injection?

Brief Answer: Detail below. Detailed Answer: Hello, Thanks for posting your query. Enbrel is etanercept,it is a biological medicine which is used for treating inflammatory conditions such as rheumatoid arthritis and ankylosing spondylitis. Intacept Injection blocks the TNF (tumor necrosis factor alpha) that causes inflammation. Etanercept works by decreasing a certain protein produced by the immune system. The immune system helps the body fight infections. In people with autoimmune disorders, the immune system mistakes the body's own cells for invaders and attacks them. This is very effective treatment. The drug is especially dangerous for people with chickenpox. It can also lead to nervous system problems such as sclerosis and seizures. It can also weaken the heart and lead to heart problems. It should be avoided by people who are allergic to latex, are pregnant or are planning to do so, have been in close proximity to a person with chicken pox. fever, night sweats, weight loss, tiredness; feeling full after eating only a small amount; pain in your upper stomach that may spread to your shoulder; easy bruising or bleeding, pale skin, feeling light-headed or short of breath, rapid heart rate; or nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Stop using etanercept and call your doctor at once if you have any of these other serious side effects: signs of infection (fever, chills, sore throat, body aches, confusion, neck stiffness, flu symptoms); shortness of breath with swelling, rapid weight gain; chest pain, ongoing cough, coughing up mucus or blood; signs of skin infection such as itching, swelling, warmth, redness, or oozing; black, bloody, or tarry stools; changes in mood or personality (in children); numbness, burning, pain, or tingly feeling; home drugs a-z list side effects drug center enbrel (etanercept) drug - patient side effects and images Enbrel Patient Information Including Side Effects Psoriasis: Rashes, Symptoms, Treatments Psoriasis Slideshow Pictures Psoriasis Quiz: Test Your Medical IQ Moderate to Severe Forms of Psoriasis Slideshow Find Lowest Prices on Brand Names: Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick Generic Name: etanercept (Pronunciation: ee XXXXXXX er sept) What is etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? What are the possible side effects of etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? What is the most important information I should know about etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? What should I discuss with my healthcare provider before using etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? How should I use etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? What happens if I miss a dose (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? What happens if I overdose (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? What should I avoid while using etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? What other drugs will affect etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? Where can I get more information? What is etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? Etanercept works by decreasing a certain protein produced by the immune system. The immune system helps the body fight infections. In people with autoimmune disorders, the immune system mistakes the body's own cells for invaders and attacks them. Etanercept is used to treat the symptoms of rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis, and to prevent joint damage caused by these conditions. It is also used to treat plaque psoriasis in adults and polyarticular juvenile idiopathic arthritis in children who are at least 2 years old. Etanercept may also be used for purposes not listed in this medication guide. What are the possible side effects of etanercept (Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using etanercept and call your doctor right away if you have any of these symptoms of lymphoma: fever, night sweats, weight loss, tiredness; feeling full after eating only a small amount; pain in your upper stomach that may spread to your shoulder; easy bruising or bleeding, pale skin, feeling light-headed or short of breath, rapid heart rate; or nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Stop using etanercept and call your doctor at once if you have any of these other serious side effects: signs of infection (fever, chills, sore throat, body aches, confusion, neck stiffness, flu symptoms); shortness of breath with swelling, rapid weight gain; chest pain, ongoing cough, coughing up mucus or blood; signs of skin infection such as itching, swelling, warmth, redness, or oozing; black, bloody, or tarry stools; changes in mood or personality (in children); numbness, burning, pain, or tingly feeling; joint pain or swelling with fever, swollen glands, muscle aches, chest pain, unusual thoughts or behavior, and/or seizure (convulsions); or patchy skin color, red spots, or a butterfly-shaped skin rash over your cheeks and nose (worsens in sunlight). Less serious side effects may include: mild nausea, vomiting, mild diarrhea, mild stomach pain; runny or stuffy nose, cold symptoms; or headache. I hope this answers your query. In case you have additional questions or doubts, you can forward them to me, and I shall be glad to help you out. Hope I have answered your query. Let me know if I can assist you further.