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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What are the chances of cervical cancer despite negative HPV test results?

Answered by
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Dr. Suresh Heijebu

General & Family Physician

Practicing since :2010

Answered : 3576 Questions

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Posted on Tue, 21 Aug 2018 in Cancer
Question: If a woman tests positive for HPV, but negative for HPV 16, 18 and 45, how much is her risk for any cancer increased over testing completely negative for HPV?
Is there a reference somewhere to find which strains of HPV put a woman at risk and for what? Same question for a man.
Is it currently possible for a man to get tested to determine if he is a carrier?
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Answered by Dr. Suresh Heijebu 2 hours later
Brief Answer:
Risk of cervical cancer still exists from other strains.

Detailed Answer:

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

Usually the strains that cause cervical cancer from a standard international souce are/ reference as follows -16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 70, 73, 82.

Among which strain 16, 18 are more common.

Hence based on above facts the risk of acquiring cervical cancer from other strains still exists even though it's lower.

Cervical smear testing helps to identify if there is any changes suggestive of HPV induced cancer, rather than screening for viral strains.

In case of a male the following strains are responsible

Carcinoma of anus

16, 31, 32, 33

Carcinoma of penis

16, 18

Yes, a man can also screen himself for these strains through appropriate blood tests.

Hope I have answered your query. Let me know if I can assist you further.

Above answer was peer-reviewed by : Dr. Nagamani Ng
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Follow up: Dr. Suresh Heijebu 7 hours later
What is the name of the test (How do I ask for it) that a man can request to determine if he is positive for HPV and the specific strain? The information I keep finding says there is no "approved" test. I am not as concerned with whether the FDA has approved the test as I am getting accurate information.
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Answered by Dr. Suresh Heijebu 2 hours later
Brief Answer:
FDA non approved ELISA can be taken by men

Detailed Answer:
Hello Sir,

Detection of human papillomavirus (HPV) DNA is now approved by the US Food and Drug Administration (FDA) and is valuable as a screening tool in women older than 30 years.

Currently, there is no HPV test recommended for men.

The only approved HPV tests on the market are for screening women for cervical cancer. They are not useful for screening for HPV-related cancers or genital warts in men. Screening for anal cancer is not routinely recommended for men.

But having said that, if a man wishes to detect the viral load in his body, the following tests are advised:

Enzyme-linked immunosorbent assay (ELISA) for immunoglobulin G (IgG) antibody (Ab) against HPV 16 capsid.

Southern blot (highly sensitive but time-consuming), dot blot, and in situ hybridization.

Hope I have answered your query.

Take care

Dr. Suresh Heijebu, General & Family Physician

Above answer was peer-reviewed by : Dr. Arnab Banerjee
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