Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
186 Doctors are Online

Taking simvistatin. Test showed elevated AST and AST level. What's going on?

Mar 2013
User rating for this question
Very Good
Answered by
Practicing since : 1998
Answered : 5956 Questions
Hi i just recieved liver test results ast 38, alt 61. I have been on simvistatin for 6 months.
what is going on with my liver??
Posted Wed, 6 Mar 2013 in Liver and Gall Bladder
Answered by Dr. Aarti Abraham 48 minutes later
Thanks for your query.
Your liver performs many functions pertaining to digestion, detoxification and protein, carbohydrate and medication metabolism. It produces and secretes several enzymes that have various roles throughout the body systems. Elevated levels of these enzymes can indicate mild to severe diseases that affect the liver or other organs. Treatment to control high cholesterol can also contribute to elevated liver enzymes.
AST (Aspartate transaminase) also called SGOT (Serum Glutamic Oxalocetic Transaminase) or ASAT (Aspartate Aminotransferase) is similar to ALT (Alanine Transaminase). AST is an enzyme associated with liver parenchymal cells found primarily in the liver, heart, kidney, pancreas and muscles. It is seen in tissue damage, especially the heart and liver. The lab values are raised in acute liver damage, but is also present in red blood cells, cardiac and skeletal muscle and is therefore not actually specific to the liver.

Normal Adult Range: 5 - 40 IU/L

ALT (Alanine Transaminase) also called SGPT (Serum Glutamic Pyruvic Transaminase) or or ALAT (Alanine Aminotransferase) is an enzyme present in hepatocytes (liver cells). Decreased ALT in combination with increased cholesterol levels is seen in cases of a congested liver. We also see increased levels in mononucleosis, alcoholism, liver damage, kidney infection, chemical pollutants or myocardial infarction.

Normal Adult Range: 7 - 56 IU/L

Hence, your results are not ominous, but high normal.
According to the Centers for Disease Control and Prevention, cholesterol medications are among the most prescribed medications in the United States. Among the many medications used to control cholesterol are statins. Statins work primarily in the liver by blocking a substance it needs to produce cholesterol, forcing the liver to remove cholesterol from the blood. Statins have many side effects, including increasing liver enzyme production. Untreated elevated enzymes can eventually lead to permanent liver damage. Therefore, if you start a statin regimen to manage your cholesterol, your physician may begin routine liver function tests to monitor your liver enzyme levels and adjust your treatment as necessary.

I think your liver enzymes are mildly elevated due to Simvistatin ( statin group ) and you need not worry at present.

Please consult your treating physician to make relevant dose adjustments and to rule out other causes of elevated liver enzymes.

Take care, and feel free to ask for further clarifications.
Above answer was peer-reviewed by
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Lab Tests
Medical Topics

The user accepted the expert's answer

Ask a Gastroenterologist

© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor