Suggest ways to wean off Isosorbide mononitrate

Posted on Tue, 26 Apr 2016 in Medicines and Side Effects
Question: I am concerned about the side effects of isosorbide mono,because I have taken 60 mg. for 4 yrs. after 5 stents and triple bypass....Was hoping to get off of it...but it looks like it's what's keeping me alive,the pain in muscles,legs,etc. is really bad. Is there another way?
Answered by Dr. Muhammad Hanif 6 hours later
Brief Answer:
Nitrates are mandatory to keep your blood vessels patent!!!

Detailed Answer:
Welcome to HCM!

Thanks for consulting at this health forum. I am happy to assist you today with all the genuine health concerns you have.

I feel sorry for the health issues you have. Nitrates are the lifesaving medications that cause dilatation of blood vessels and keeps the heart vessels patent too. It also decreases the workload on heart muscles that eases the failing heart's functions.

There isn't a direct musclular side effect that may have caused issues for you. It actually causes lowering of blood pressure that may also lead to Orthostatic hypotension in addition to muscle weakness. For symptoms like you have, we usually suggest more precautions rather than discontinuing the drug. You are right in your statements about this medication as this really is a lifesaving drug. You need to avoid standing long upright. Avoid fast standing from sitting or laying down posture. Avoid strenuous work, running, brisk walking, lifting weight etc. Avoid hot and humid environment and keep yourself well hydrated.

I also suggest you to ask your Physician for your Thyroid Profile testing, Vit. B12 and Vit. D levels, Serum proteins, lipid profile and CBC to rule out other causes of muscles aches.

Keep a balanced and healthy diet. Seafood, salads, fruits, vegetables are best for you. Avoid processed red meat and refined food.

Final Suggestion :-
Before you stop taking any medications please check with your treating Physician and ask to rule out other major causes of muscle aches first. Nitrates are lifesaving medication and needed for you on regular basis. Also ask your Physician if any other medication is interaction with your Isosorbide mononitrate.

Hope it helps you today. Please feel free to ask for further assistance if you gave more queries. I will be happy to help.

Above answer was peer-reviewed by : Dr. Prasad
Answered by
Dr. Muhammad Hanif

General & Family Physician

Practicing since :2009

Answered : 2369 Questions


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