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Suggest Treatment For Thyroid

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Posted on Wed, 25 Feb 2015
Question: had a TT 3 years ago. tsh 0.21 and normal range t3 and t4. on 88mcgs synthroid qd
endo just reduced by 1/2 tab 1 day/week
doctor
Answered by Dr. Binu Parameswaran Pillai (1 hour later)
Brief Answer:
Low TSH indicates over replacement

Detailed Answer:
Good day,
Noted your concern. If you have total thyroidectomy, you will need full replacement dose of thyroxine. May i know your weight please?

TSH of 0.21 is little on the lower side and indicates over replacement. That is the reason why your doctor reduuced the dose of synthroid .
Please recheck TSH after 6 weeks on new dose
Regards
Binu
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Binu Parameswaran Pillai (13 minutes later)
Its around 165-170
Doctors cannot understand why I need such a low dose
How long will it take for a normal level
And why wouldn't he take me down to next lower dose
Thank you
doctor
Answered by Dr. Binu Parameswaran Pillai (15 minutes later)
Brief Answer:
You may have some thyroid tissue left behind

Detailed Answer:
Thank you for the reply. If you are 170 lbs, then your total requirement would be approx 120 mcg daily of synthroid. If you are requiring a smaller dose, that means, you still have some thyroid tisue left behind in your neck on the operated site. I often come across this scenario. An ultrasound may show some thyroid tissue in your neck.

Once the dose has been modified, it takes around 6 weeks for the TSH to stabilize and that is the best time to recheck again.
It is not good to cut down the dose too much at a time,

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Binu Parameswaran Pillai (28 minutes later)
Wow
That's what I thought
I had an ablation x 2 then finally a total substernal thyroidectomy
But can't understand why my levels have gone down after 4 months of the same dose And always compliant
doctor
Answered by Dr. Binu Parameswaran Pillai (8 hours later)
Brief Answer:
Viable thyroid cells in neck

Detailed Answer:
May i know what was the indication of idoine ablation ( Grave's disease?).
There is something called "Thyroid stunning" by radio idoine ablation. You have required 2 doses of iodine ablation and still didnt become normal or hypothyroid and required a surgery. This means that, your thyroid cells were not fully killed by the radio idoine doses. Rather, some of the thyroid tissues would have been stunned by radio idoine. These tissues can recover their function gradually over a period of time and start secreting thyroid hormone again. If the surgery didnt remove all the thyroid tissues, gradually the left over thyroid tissues will recover from the previous stunning and start secreting. This is my "hypothesis". This would explain your situation.

As i explained earlier, an ultrasound of neck will probably give an answer. If it shows thyroid tissue in neck with normal vascularity, that means those thyroid cells are still viable and would be secreting atleast some Thyroid hormone. However, i must say that many of these cells eventually die from previous exposure of radio iodine and in that case, in future, the requirement of thyroxine can go up.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Binu Parameswaran Pillai (1 hour later)
Ablation x2 in 2001 due to multinodular goiter
Did not need replacement therapy
Then tt from substernal thyroid of rather large size in 2012
doctor
Answered by Dr. Binu Parameswaran Pillai (46 minutes later)
Brief Answer:
Multinodular goiter

Detailed Answer:
Okay. It means the thyroid cells were not fully killed by two ablations. It probably was due to either mutation in the multinodular goiter or due to large volume of thyroid cells in multi nodular goiter. From the history so far, I suspect you may have some small thyroid tissue in neck area which is still secreting small amount of hormone.
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Binu Parameswaran Pillai

Endocrinologist

Practicing since :2003

Answered : 1439 Questions

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Suggest Treatment For Thyroid

Brief Answer: Low TSH indicates over replacement Detailed Answer: Good day, Noted your concern. If you have total thyroidectomy, you will need full replacement dose of thyroxine. May i know your weight please? TSH of 0.21 is little on the lower side and indicates over replacement. That is the reason why your doctor reduuced the dose of synthroid . Please recheck TSH after 6 weeks on new dose Regards Binu