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Suggest Treatment For Side Effects Of Xolair

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Posted on Fri, 16 Jan 2015
Question: My urticaria started 8 moths ago and until the November no drug was able to fix my situation.My doctor told me that there is a injection named as XOALIR and it cures the urticaria.I took the injection a month ago and my problems started immedietly.(150+150 mg from both arms)

Chornicles of what happened to me after the injection.

November 20th - November 21th : I took the injection in November 20th at 05.00 PM.Immedietly after taking the injection I felt terrible vertigo and dizznes,it felt like my blood pressure dropped.I went home hardly and slept all night,my doctor told me that it will pass.

November 21 th –€・November 25 th : Dizznes and vertigo almost past but I had a chest pain,I was afraid maybe its was releated to a heart problem and went to hospital.They checked it and they found no problems.Until the november 25 everything seemed fine except chest pain.

November 25 th –€・December 7:This where the nightmare begin,in the morning of the November 25th at 09:00 am while driving a car I felt terrible dizznes and vertigo suddenly.I was too harsh and terrible and I barely reached to school.For an hour I wait for it pass and then I talked with my doctor.Again she said that it was not releated to the Xoalir and told me to go to neurologist.I went to hospital they made some tests(Brain Mr and EKG).My neurologist didnt found any problems so she told me that maybe it was something releated to diabetese.Couple days later a diabet doctor made me some blood test(diabet test) and again nothing was found.Days later.I went to a another neurologist and she recognies the drug.She read the description of the drug and told me that these are all known side effects and these will pass.Unil I reached the december things were terrible,I was not able to drive a car and my life was ruined.Vertigo and dizznes were too strong and it ruined my life.I failed on all my exams and lessons during this time.

December 7 th –€・December 15 th : Things got better during this period,the chest pain was almost gone,dizzness and vertigo was very little.I returned school and I was able to drive a car again.I thought that things will get better when I reach the end of the December,because doctors said that this injection will last on your body for a month.

December 15 th –€・December 20 th : Things got worse again.Starting from december 15th dizzness and vertigo come back.I just dont feel well.This time I tried to fight against it but I am getting tired of feeling like a zombie everyday.

So today is December 20 th its has been a month since I take the injection and with the returning of the side effects again my life is ruined.My psycology is at the bottom and I dont know how the hell I will live like this.I prey god everday to save me from this nighthmare.During all these period urticaria was not seen on body so drug really stops it but I wish it come back now because all these side effects are much worse than that.

So is my problems are caused because of XOALIR,for me its the reason but I really want you to tell me the problem is.
doctor
Answered by Dr. Prasanna Heijebu (3 hours later)
Brief Answer:
Xoalair side effect.Deslor and Betahistine will help.

Detailed Answer:
Hi Sir,

I understand your query and concern.

The symptoms of Dizziness and recurrent vertigo in your case are strongly related to the side effect of the drug XOALIR.

This drug is known to cause serious dizziness and vertigo in sensitive individuals.This dizziness can be long lasting in few individuals.

Its extremely important that you be placed on medications that relieve these attacks of vertigo and dizziness so that you show a faster clinical recovery before it worsens the quality of your life.

Drugs like Betahistine and Desloratidine at bedtime can cause rapid amelioration of your symptoms.

Please note these drugs have to be taken only under strict medical supervision.

XOALAIR will take apprx 3-6 weeks from the body to washout completely.

Post your further queries,if any.
Thank you.
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Prasanna Heijebu (3 hours later)
I received xolair because of urticaria so is these drugs cause urticaria problem ? Also are they going to make me feel well for a night or for all day ?

Is these side effects will pass ? Why do you think that they come back after some time ?

I will inform my doctor about the situation but any further info will be good.

Thanks
doctor
Answered by Dr. Prasanna Heijebu (3 hours later)
Brief Answer:
Sideeffects will fade away gradually

Detailed Answer:
Hi Sir.

I understand your query and concern.

Xoalir is absolutely not indicated to treat urticaria.You have been misguided at some point.

Betahistine and Deslor absolutely do not cause any urticaria.

Deslor is rather used in the treatment of urticaria.Its a excellent drug used to control urticaria and itching.

The above mentioned drugs are long acting and hence keep you well all through the day.
These Xoalir related side effects will pass off gradually.Relapses are frequent due to drug redistribution.But they fade away in 3-6 weeks.

Please consult your doctor with regards to the above for more info.

Post your further queries,if any.
Thank you.
Above answer was peer-reviewed by : Dr. Yogesh D
doctor
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Follow up: Dr. Prasanna Heijebu (23 hours later)
"Xoalir is absolutely not indicated to treat urticaria.You have been misguided at some point."

What ?? Even the xoalir website says that its meant for Chronic Idiopathic
Urticaria ???

Are you sure ?
doctor
Answered by Dr. Prasanna Heijebu (35 minutes later)
Brief Answer:
Xoalir is only rarely used for urticaria based on risk benefit ratio only

Detailed Answer:
Hi Sir.

I understand your query and concern.

Let me clarify to you that xoalir contains Omalizumab which is an antiIgE monoclonal antibody.

Its predominantly introduced to treat the allergic broncho spasm of asthma.

Its prime role is never to treat urticaria.

Its never used in any urticaria except Chronic idiopathic urticaria(only as a last resort drug) -meaning urticaria lasting for more than 6 months without any demonstrable identifiable cause including allergy(negative skin tests to all available standard skin tests) and that which has not responded to any standard first line drugs like antipruritic and antihistamine drugs for more than 3 months of continuous use.

I hope this is definitely not the case with you.

More over Xoalir is still under clinical evaluation trials for urticaria as the treatment duration for CIU is not evaluated as yet.

A drug can have multiple actions, but it does not imply that it can be used for all such conditions.

Thank you.
Above answer was peer-reviewed by : Dr. Ashwin Bhandari
doctor
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Follow up: Dr. Prasanna Heijebu (3 hours later)
My urticaria lasted more than 8 months also 5 years ago it lasted for 3 weeks so this 8 month period was a comeback.

The antihistamins were not useful in my condition only kortizol works but it also had side effects and after using it a lot I accepted to take xoalir.

So still wrong theratment ?

Also is this going to pass ? Is it possible that this problem will stay ?

İs there anything I can get out of this misery ?
doctor
Answered by Dr. Prasanna Heijebu (6 hours later)
Brief Answer:
You will get well soon ,dont worry.

Detailed Answer:
Hi Sir,

I do not mean wrong treatment by my earlier answer,but i want to say that its not the standard choice of therapy based on risk benefit ratio.

Recurrence does not account to CIU.

CIU should primarily include negative skin tests to all standard investigations,which is absent in your case.

The risk benefit ratio pertaining to Xoalir is >1,which means the advantage obtained by using the drug xoalir for urticaria is far less than the risk of acquiring vertigo with the use of xoalir.

Finally i suggest you not to get overwhelmed with worry,as this dizziness is going to wane off slowly.

This problem will definitely not persist.

Please do not go into misery as this is very much a reversible situation.

Thank you.
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
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Follow up: Dr. Prasanna Heijebu (20 hours later)
Thank you for these words it didnt made me feel better (vertigo all over) but at least I am hopeful now.

These dizzness situation followed a strange path actually.

If we didnt count first couple days,I felt bad at the start then for a week I was okay then I felt bad again,it was like drug entered my body and my body reacted it after some time it got used to it then now maybe its absent on my body and again my body is getting used to its absencty.This is just a stupid theory of mine so is it true ?

Can you give a me a date or an guess,I always expected to feel well after 30 days and today its the 33 day and I am bad,you said that it can last for 6 weeks so is this thing continue for two or weeks or it may go off tomorrow ?

Lastly for gods sake will it ever return if it pass in later times ?
doctor
Answered by Dr. Prasanna Heijebu (1 hour later)
Brief Answer:
It should hopefully pass away in another 2 weeks.

Detailed Answer:
Hi Sir,

I understand your query and concern.

The frequent unpredictable attacks of vertigo in your case is due the phenomenon of drug redistribution.

The attacks come and go as long as the drug stays in the body.

The drug is slowly released from the depot sites until its is fully washed away.

It may take another 2 weeks to resolve.

Once it passes off on a longer interval, it will not probably return again.

Thank you.

Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
Answered by
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Dr. Prasanna Heijebu

General & Family Physician

Practicing since :2010

Answered : 1422 Questions

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Suggest Treatment For Side Effects Of Xolair

Brief Answer: Xoalair side effect.Deslor and Betahistine will help. Detailed Answer: Hi Sir, I understand your query and concern. The symptoms of Dizziness and recurrent vertigo in your case are strongly related to the side effect of the drug XOALIR. This drug is known to cause serious dizziness and vertigo in sensitive individuals.This dizziness can be long lasting in few individuals. Its extremely important that you be placed on medications that relieve these attacks of vertigo and dizziness so that you show a faster clinical recovery before it worsens the quality of your life. Drugs like Betahistine and Desloratidine at bedtime can cause rapid amelioration of your symptoms. Please note these drugs have to be taken only under strict medical supervision. XOALAIR will take apprx 3-6 weeks from the body to washout completely. Post your further queries,if any. Thank you.