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Suggest Treatment For Postpartum Preeclampsia And Hypertension

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Posted on Mon, 10 Aug 2015
Question: I am a 41 year old female who developed postpartum preeclampsia, with a bp of 180/100 and protein in my urine. My blood work was normal. The protein reduced and I was medicated for the bp and discharged.

I am now 7 weeks postpartum and still medicated. My urine no longer has protein. My doctor thinks I have essential hypertension but the medication keeps my bp too low
100/70. However, in the late evening it spikes to around 170/105. I can usually bring it down to 130/80 through breathing and relaxing. I do have anxiety but I am on atenolol that brings my hr down to about 55 and I don't feel stressed when I take it. What could be causing these spikes? They are nearly every night. I take the atenolol at 8am and the spikes happen around 10pm. However, I always wake up with normal numbers. Last night I went as high as 170/105 at 11pm and this morning (25 hours after my 50mg dose of atenolol and 13 hours after my 10mg dose of enalapril) my bo was 120/80. I'm so confused.
doctor
Answered by Dr. Rakesh Madhyastha (24 minutes later)
Brief Answer:
inadequate dosing

Detailed Answer:
hello

Thanks for the query

Your doctor is right about it being essential hypertension and you are on the right pills however you are not taking the adequate dosing.
Here is what I recommend

1. Atenolol is ideally taken twice daily. I suggest you to taken atenolol in the evening as well
2. continue to take enalapril, it protects your kidneys. However I must warn you that it should not be taken if you are planning pregnancy
3. if you are not tolerating atenolol dual dose then I recommend you to be switched to amlodipine instead

I hope I was of help, if you have any further queries please get back to me

Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Rakesh Madhyastha (20 minutes later)
Until a couple of days ago I was on labetalol 200 mg 3 times daily. I took a dose at 8pm as well as 10mg of enalapril. I would still get the spikes at around 10/11pm. Also, if my pressure on the atenolol 50mg is 100/70 with a pulse of
50-55, wouldn't an increased dose send me too low? Especially sleeping
doctor
Answered by Dr. Rakesh Madhyastha (28 hours later)
Brief Answer:
Dividing the dose is essential

Detailed Answer:
Hello

Thanks for getting back. I am sorry for the short delay in my reply, I was on call at my hospital

I am very confused about what you are taking currently.

I want to clarify it properly so that I don't make any mistake
1. You currently on atenolol 50 mg in the morning and enalapril twice a day
2. you have stopped taking labetolol
3. what is your heart rate in the evening when you are having high blood pressure ? do you get dizzy as well?

I were to be you doctor I would stop atenolol as both enalapril and atenolol act on the renin angiotensin system. I would continue enalapril ( most essential medication ) and add amlodipine. The advantage being it won't cause fall in heart rate and is a long acting drug

I am once again sorry for the delay

Regards
Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
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Follow up: Dr. Rakesh Madhyastha (4 hours later)
I am on 50mg of atenalol at 8 in the morning. I take 10mg of enalapril at 8 at night.

When my BP goes high my heartrate doesn't change - its still below 55.

I have been tracking my BP every hour for the last couple of days to review the medication change. Tonight it didn't go as high: the highest was 140/105 and 158/95. However, these were first readings and I had a heartrate of around 70 when I took them so I must have been stressed. I settled at around 120/85 with a heartrate of 53.

I am very keen to come off beta blockers. I have a normal heart and I am disappointed that my doctor went to them first (Labetalol was prescribed postpartum at the hospital and so was enalapril as my BP didnt respond to labetalol at first). I am only 41 and I have two infant children - I feel like a zombie. How would you suggest that I wean off them? My doctor is a good one but clearly not skilled in this sort of thing.

I have been thinking that enalapril at 10mg twice a day (so 20mg) and another drug that is not a beta blocker may be the way to go for me. Can you tell me about the drug that you suggest and why you have selected that?

One last question: do you have any idea why this has happened to me? I am in excellent health and I have no family history of high BP. No one ever commented about my BP before pregnancy or at the beginning of this pregnancy either. My doctor thinks that underneath all these meds my BP is running at 150-160/95-100, which is significant hypertension. I wasn't even prehypertensive before.
doctor
Answered by Dr. Rakesh Madhyastha (10 hours later)
Brief Answer:
Uncontrolled hypertension

Detailed Answer:
Hello

Thanks for sorting things out for me.

I recommend that you come off atenolol. There is no weaning off, you will just have to take amlodipine from the next day.
Amlodipine is a longer acting drug than atenolol and does not reduce heart rate like atenlol. So if bp goes high in the evening you can take another pill.

The most important aspect of blood pressure control is to restrict salt intake and also exercise daily. Cardiovascular exercises like jogging, running , cycling are the best.

Essential hypertension need not be familial and I am not suspecting secondary hypertension where one's blood pressure goes high for several other reasons.

Regards
Note: For further queries related to kidney problems and comprehensive renal care, talk to a Nephrologist. Click here to Book a Consultation.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Rakesh Madhyastha

Nephrologist

Practicing since :2009

Answered : 4364 Questions

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Suggest Treatment For Postpartum Preeclampsia And Hypertension

Brief Answer: inadequate dosing Detailed Answer: hello Thanks for the query Your doctor is right about it being essential hypertension and you are on the right pills however you are not taking the adequate dosing. Here is what I recommend 1. Atenolol is ideally taken twice daily. I suggest you to taken atenolol in the evening as well 2. continue to take enalapril, it protects your kidneys. However I must warn you that it should not be taken if you are planning pregnancy 3. if you are not tolerating atenolol dual dose then I recommend you to be switched to amlodipine instead I hope I was of help, if you have any further queries please get back to me Regards