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Suggest Treatment For Mysasthenia Gravis

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Posted on Mon, 16 Jun 2014
Question: Thank you, Doctor Munoz, for answering my question regarding Mysasthenia Gravis and current allopathic treatment. Frankly I am not favorably disposed toward the standard medical treatment for this ailment.

First, I would proffer that it is a disappointment that allopathic medicine can offer no cure for the disease, MG. Second, I find it incredulous how casually the next course in futility is recommend. i.e.,to begin taking a statin drug (with a menu of probable or possible adverse effects). Thirdly, to suggest suppressing my immune system to quiet (?) the vigorous gnawing activity of straying T-Cells--only to expect an infection or two from this strident act, is, well, pick an expression of disbelief. All that without any hope of a cure in sight.

I have spent somewhere close to $6000 for doctor visits and treatment over the past 10 months. Have I seen improvement ? Not an iota! Still have double vision. Still have weak neck muscles so that I must hold my head up when I go for a walk. And, perhaps the second obstacle to recovery is difficulty swallowing--second to double vision. Since Christmas Day, 2013, I have been forced to "chew my cud," or regurgitate almost every bite of well-chewed morsels.

On the pharmacy printout on Pyridostigmine, there is a paragraph on Overdosing. Of course, overdosing can mean different doses to each different patient. (My neurologist felt at ease to raise my doses to 90 mg four time a day.) In concert with the overdose write-up, I was sweating heavily, salivating profusely, experiencing blurred vision, and having great difficulty swallowing anything.
(I even had a Barium test to see if I had an obstruction in my throat.) No obstruction was found; however, the camera study did discover that the peristalsis of the esophagus had ceased. Eureka!
The gastroenterologist still wanted to run a camera down my throat to have a look for himself. No!

I took it upon myself to independently experiment for two days by withdrawing from taking Pyridostigmine, and what happened? 1. No dizziness. 2. No sweats. 3. No blurred vision, and 4.
No difficulty swallowing!! I could swallow everything I ate! I don't know if the peristalsis returned or not, but I could swallow without drinking several sips of water to wash the food down and into the stomach. Wow!

Then I thought to myself, maybe I shouldn't quit the drug altogether, so I took 2 tables at 60 mg yesterday 4 hours apart. How did I do today? Not well. I regurgitated almost everything I ate.
I could not get anything down without water following. I ate some mixed nuts coming home from the grocery store. I got home just in time to jump out of the car and regurgitate all of the masticated and swallowed nut meat back out of my mouth and onto the lawn. I also have a hiatal hernia, but it appears to have no part in the swallowing drama. Tonight, as I write this email, Doctor, I am still generating a large amount of saliva.

Maybe tomorrow I'll ingest only one pill and follow me around taking note of what is measurably
taking place.

Thank you for your interest, Doctor.

XXXX
doctor
Answered by Dr. Jose Ignacio Artero Munoz (12 hours later)
Brief Answer:
Myasthenia Gravis,

Detailed Answer:
Hello.Delighted to be able to help.
I will try to explain point by point what you say.
1.-About"allopathic medicine can offer no cure for the disease, MG",the called Biological Therapy (monoclonal antibodies)currently is getting remission of the disease in a considerable percentage of cases. In cases with poor response to pharmacological treatments, the extirpation of the Thymus (immune organ located in the chest)too is getting remission of the disease in a considerable percentage of cases.
2.-About "Statins",are drugs contraindicated in a person suffering miastenis gravis because increases muscle weakness.
3.-The drugs that suppress the immune system can cause infections but too achieve stable disease.
4.-About Pyridostigmine;increased salivation, increased sweating, dizziness and blurred vision are side effects of pyridostigmine but weak neck muscles, double vision and difficulty swallowing are not side effects of pyridostigmine, are symptoms of the disease.As you say," the camera study did discover that the peristalsis of the esophagus had ceased".Pyridostigmine is a powerful stimulant of peristalsis of the esophagus.The difficulty for the transit of food from esophagus
to the stomach (by the cessation of peristalsis of the esophagus) is not caused by pyridostigmine(cause the opposite effect),it is a symptom of the disease.
5.-About the measurable dose of pyridostigmine,say that Pyridostigmine is not the most appropriate drug to treat your symptoms currently:Despite the decrease in the dose, you have significant side effects (sweating...)and
even with high doses your symptoms (neck muscle weakness, double vision ...)
dont improve.In this situation, as I said a few days ago, the use of Corticosteroids by mouth is recommended (Prednisone or similar).
In the short term, your doctor should consider replacing Pyridostigmine by Prednisone for improvement of your symptoms.
In the medium term, others mentioned treatments can get remission of the disease.
I Hope I have answered your query. If you have any further questions, I will be happy to help.If you do not have any clarifications, please don’t forget to evaluate my answer.I wish you good health.
Above answer was peer-reviewed by : Dr. Yogesh D
doctor
Answered by
Dr.
Dr. Jose Ignacio Artero Munoz

General & Family Physician

Practicing since :2001

Answered : 1118 Questions

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Suggest Treatment For Mysasthenia Gravis

Brief Answer: Myasthenia Gravis, Detailed Answer: Hello.Delighted to be able to help. I will try to explain point by point what you say. 1.-About"allopathic medicine can offer no cure for the disease, MG",the called Biological Therapy (monoclonal antibodies)currently is getting remission of the disease in a considerable percentage of cases. In cases with poor response to pharmacological treatments, the extirpation of the Thymus (immune organ located in the chest)too is getting remission of the disease in a considerable percentage of cases. 2.-About "Statins",are drugs contraindicated in a person suffering miastenis gravis because increases muscle weakness. 3.-The drugs that suppress the immune system can cause infections but too achieve stable disease. 4.-About Pyridostigmine;increased salivation, increased sweating, dizziness and blurred vision are side effects of pyridostigmine but weak neck muscles, double vision and difficulty swallowing are not side effects of pyridostigmine, are symptoms of the disease.As you say," the camera study did discover that the peristalsis of the esophagus had ceased".Pyridostigmine is a powerful stimulant of peristalsis of the esophagus.The difficulty for the transit of food from esophagus to the stomach (by the cessation of peristalsis of the esophagus) is not caused by pyridostigmine(cause the opposite effect),it is a symptom of the disease. 5.-About the measurable dose of pyridostigmine,say that Pyridostigmine is not the most appropriate drug to treat your symptoms currently:Despite the decrease in the dose, you have significant side effects (sweating...)and even with high doses your symptoms (neck muscle weakness, double vision ...) dont improve.In this situation, as I said a few days ago, the use of Corticosteroids by mouth is recommended (Prednisone or similar). In the short term, your doctor should consider replacing Pyridostigmine by Prednisone for improvement of your symptoms. In the medium term, others mentioned treatments can get remission of the disease. I Hope I have answered your query. If you have any further questions, I will be happy to help.If you do not have any clarifications, please don’t forget to evaluate my answer.I wish you good health.