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Suggest Treatment For Hypertension And Sleeplessness

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Posted on Thu, 4 Sep 2014
Question: Yes Doctor...This is my wife's case Aged 52 Known case of Hypertension (since early twenties.. probably not treated before marriage) and DM II since last 15 yrs. After her marriage at age 35 she is being treated for these conditions. [ Also she was almost given up as dead @ age 29 when there was no pulse(due to acute dehydration; but survived after hospital treatment ] After marriage i had also noticed a state of agitated and discontented mind for which off-on psychiatric treatment was given.
July 2013 she started complaining of acute sleeplessness and constant dizziness for which treatment was given but no respite ; also some tendency of appearing to fall down while standing was noticed ; immediately Neurologist was contacted and MRI done. Findings: Study reveals multiple confluent and discrete T2W / FLAIR hyperintense foci in bilaterol supertentorial periventricular and subcortical white matter as well as in right pontine delly without any evidence of restricted diffusion on DWI. Findings are suggestive of microangiopathic white matter ischemic demyelination changes. The Neuro advised Ecospirin 150 OD ; Coltro 20 TDS & Vertin 8 mg TDS . This treatment alongwith Psychiatric treatment enabled her Travel alone from XXXXXXX to XXXXXXX (and return after 2 months) by Train (a journey of 17 hrs. with Boarding and deboarding help @ either side)
In XXXXXXX 2014 2nd half of the mo. she fell down at home uncontrolled. Hospital admission was done and after various tests like Doppler , Holter and others she was discharged after one week with diagnosis of Type 2 DM; HTN, Vertigo, and Depression...medicines adviced include amongst others Ecospirin 75 OD & Trental 400 mg. TDS. After discharge it was noticed that she was gradually getting immobile and she also sufferd a fall injury on her forehead. Advised admission again 24 days after the last discharge... and as it turned out there was a huge big hematoma on left side of head. she remained in hospital for 3 weeks and discharged on 29th march ' 14 with following Diagnosis: Left frontotemporo-parietal SDH ; Type 2 DM ; HTN ; Depression ; Bilateral Knee OA. Also it skipped Hospitals attention that she also has a vaccu-compressed L2-L3 zone for which thgere is distress in the Lumbar region. Earlier on regularly she was being given 10 sessions of Physio / mo. @ cervical / Lumbar /Knee areas for the last many years. I am skipping the medicines for DM@ and HTN / acidity /constipation and mild Thyroid. Other (Brain ) medicines given were Levepil 500mg. BD ; Amantrol 100 mg BD Proctanil 1.25 mg TDS Physio / mobilisation was advised. The medicines continued till last week of July. In the first three mos. there was very small improvements in her walking assisted....(steadiness) but since 1st wk. July the condition seemed deteriorated with tendency to fall and even some stooping at times during assisted walking. Agaim matter was taken up with the earlier doctor who advised admission again... But we declined and instead went to another Neurologist. The New Neurologist got a fresh MRI and EMG/NCV/EP ; VEEG & BAER Tests done.Last MRI opinion : Findings suggestive of old hemrrohage sequelae with hemosiderin staining in left basal Ganglia with chronic supratentoril lacunar infarcts and significant periventricular ischemic demyelination along with age related cerebral atrophic changes. Pl. correlate clinicalyy... VEEG... Normal awake VEEG recordThe NeuroNCS study is abnormal suggestive of moderatemixed sensory motor. axonal and demyelinating peripheral Neuropathy (left> Right) BAER study ...also normal
Now the Brain medicines suggested are as before But..... Levepil 250 .. BD ; Inderal 20 TDS ; Amantrol 100 BD... additionally Syndopa 125 TDS Lecosam 50 BD ; Samemax 200 BD ; & Cap ARQ-10
Doctor concerned did not give a very good longterm Prognosis (worst case scenario ultimately bed-ridden with very little limb movements) so i consulted another renowned Neuro who said that with drugs she can be somewhat XXXXXXX
Due to all these negatives (as against after the hematoma the earlier doctor had guranteed full recovery) i have started Ramdev's XXXXXXX (ayurvedic) as well as Homeopathic treatments.
Meanwhile HTN and DM are being kept under control and regular Physio/assisted walking being done (But there is convulsive type whole body undulations about once/2 ice especially at nights; Kindly advice a single/two allopathic medicines for this condition alone)
Also Kindly advise the Long-term possibility of cure (i.e she starting to walk normally with steadiness
alone as before if it exists in allopathic system of medicine.
Any other advice you kindly give would be appreciated. Thanks and regards..
doctor
Answered by Dr. Dr. Prasad J (8 hours later)
Brief Answer:
Seems to be progressive condition...

Detailed Answer:
Hi,

I went through your post with diligence and from what I read it looks like your wife is suffering with a progressive degenerative/ischemic condition which is affecting her body function. The events have flared up after the fall accident. She has been put on anticonvulsant drugs and dopaminergic drugs which have known for good convulsion control and improve mobility. With regular follow ups, the dose of these can be adjusted in an effort to help her move around.

As far as possibilities for long term cure is concerned, it doesn't seem to be a condition that can be reversed. However the treating doctor (with whom you regularly follow up) will be able to predict prognosis and action plans which may improve her quality of life.

Both levepil and lecosam are good anticonvulant drugs. You should talk about those convulsive type of events with the treating doctor. The doctor can analyse/compare with her past events to arrive at a conclusion which will help him/her to make adequate changes to those drugs.

Lastly, this doesn't seem to be a condition that can be treated with single or set of drugs. Her treatment has to be constantly revised based on results and side effects. Therefore it is essential to follow up with her neurologist.

Since you posted your question to general pool of doctors this query has not reached specialist (neurologist) here. I have tried to answer you with the best of my abilities based on my 4 years experience in the field of neurology. If you wish for a strong second opinion on your wife's case, I urge you to post your questions to top neurologist through Ask A Specialist option.

Wish her a speedy recovery.

Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Dr. Prasad J

General & Family Physician

Practicing since :2005

Answered : 3708 Questions

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Suggest Treatment For Hypertension And Sleeplessness

Brief Answer: Seems to be progressive condition... Detailed Answer: Hi, I went through your post with diligence and from what I read it looks like your wife is suffering with a progressive degenerative/ischemic condition which is affecting her body function. The events have flared up after the fall accident. She has been put on anticonvulsant drugs and dopaminergic drugs which have known for good convulsion control and improve mobility. With regular follow ups, the dose of these can be adjusted in an effort to help her move around. As far as possibilities for long term cure is concerned, it doesn't seem to be a condition that can be reversed. However the treating doctor (with whom you regularly follow up) will be able to predict prognosis and action plans which may improve her quality of life. Both levepil and lecosam are good anticonvulant drugs. You should talk about those convulsive type of events with the treating doctor. The doctor can analyse/compare with her past events to arrive at a conclusion which will help him/her to make adequate changes to those drugs. Lastly, this doesn't seem to be a condition that can be treated with single or set of drugs. Her treatment has to be constantly revised based on results and side effects. Therefore it is essential to follow up with her neurologist. Since you posted your question to general pool of doctors this query has not reached specialist (neurologist) here. I have tried to answer you with the best of my abilities based on my 4 years experience in the field of neurology. If you wish for a strong second opinion on your wife's case, I urge you to post your questions to top neurologist through Ask A Specialist option. Wish her a speedy recovery. Regards