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Suggest Treatment For Extra-pulmonary TB

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Posted on Sat, 22 Aug 2015
Question: Hi Doctor,

I am speaking about my mother who is aged 54 years. Last XXXXXXX 2014 she was diagnosed with Extra-pulmonary TB due to enlargement of Left armpit lymphnodes. Her fever started from 12th May 2014. She was diagnosed on 23/6/2014. She was also complaining about severe headache. Tests were carried out and TB Meningitis was proved. She started with the first line of drugs consisting of
Isoniazid-300mg
Rifampicin-450mg
Pyrazinamide
Ethambuto-1000mg
She continued Ethambutol till November 2014 when suddenly she complained of blurriness and also Green Colour blindness(to slight extent) and was diagnosed Retrobulbar Neuritis. Ethambutol was discontinued at once followed by Isoniazid within one week. MRI was carried out which confirmed the same but of very low intensity.
The drugs she had and duration:-
1) Pyrazinamide:- 2 months
2) Ethambutol and Isoniazid:- 4.5 months
3) Streptomycin:- 60 days
4) Rifamcin:- 11 months
5) Ofloxacin:- 7 months
6) Levofloxacin:- 5 months.

Doctor has asked to stop all drugs at the moment.

Her Blood Test report:-

Basophil-4(Normal is said as 3 or below)
ESR-27(Normal 20 and below)
Lymphocyte:- 44%
WBC-6800(normal below 11000)


I have also attached the recent MRI report of the brain. Can you tell me what it means?

Thanks and Regards,
XXXX XXXXXXX
Hi Doctor,

One thing I forgot to mention. Right now she is suffering from a little high pressure(155/95) which is leading to a little pain on her head.

Thanks and Regards,
XXXX XXXXXXX
doctor
Answered by Dr. Sudhir Kumar (4 hours later)
Brief Answer:
MRI brain shows mild ischemia

Detailed Answer:
Hi Mr XXXX,

Thank you for posting your query.

I have noted your mother's symptoms, diagnosis and past medical treatments.

I have seen the MRI brain report, which is suggestive of ischemia (lack of blood supply to brain). This is most probably caused due to mild increase in blood pressure.

There is no need to worry, as it can be treated with medications such as clopidogrel (to prevent further ischemia of brain).

I hope my reply has helped you.

I would be pleased to answer, if you have any follow up queries or if you require any further information.
     
Best wishes,     
Dr Sudhir Kumar MD (Internal Medicine), DM (Neurology) XXXXXXX Consultant Neurologist
Apollo Hospitals, XXXXXXX
For DIRECT QUERY to me: http://bit.ly/Dr-Sudhir-kumar
My blog: http://bestneurodoctor.blogspot.com/

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sudhir Kumar (5 minutes later)
Hi Doctor,

Thanks a lot.

Is this anything to do with TB Meningistis?

Thanks and Regards,
XXXX XXXXXXX
doctor
Answered by Dr. Sudhir Kumar (3 minutes later)
Brief Answer:
No

Detailed Answer:
Thank you for getting back.

There is no relation to TB meningitis.

Best wishes,

Dr Sudhir Kumar MD DM (Neurology)
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sudhir Kumar (2 minutes later)
Hi Doctor,

Thanks for your reply.

I forgot to mention an important detail. She was given steroids for more than three months at the beginning.

Is is needed to continue with her medicines?

Thanks and Regards,
XXXX XXXXXXX
doctor
Answered by Dr. Sudhir Kumar (7 minutes later)
Brief Answer:
Steroids are not needed now.

Detailed Answer:
Thank you for getting back.

Steroids are given in the initial 6-12 weeks of TB meningitis. Now, there is no need to give steroids.

Best wishes,

Dr Sudhir Kumar MD DM (Neurology)
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sudhir Kumar (2 days later)
Hi Doctor,

My mother has been suffering from Retrobulbar Neuritis issue from last November. She can see around 60%-70%. How long will it take to heal? She cannot read Newspapers or see person at a distance.

She stopped taking Isoniazid and Ethambutol at once after Retrobulbar Neuritis was detected(last November.

It has been almost 8.5 months that she left taking those drugs.

Thanks and Regards,
XXXX XXXXXXX
Hi,

Forgot to mention one thing. She discontinued Ethambutol and Isoniazid around 8.5 months back.

Her MRI report also shows something about Retrobulbar Neuritis.

Thanks and Regards,
XXXX XXXXXXX
doctor
Answered by Dr. Sudhir Kumar (10 hours later)
Brief Answer:
Exact timeframe for recovery can not be predicted.

Detailed Answer:
Thank you for getting back.

Retrobulbar neuritis can improve slowly on own at this stage, however, exact timeframe can not be predicted. In some cases, complete recovery may not occur.

Best wishes,

Dr Sudhir Kumar MD DM (Neurology)
Above answer was peer-reviewed by : Dr. Yogesh D
doctor
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Follow up: Dr. Sudhir Kumar (25 hours later)
Hi Doctor,

When MRI was done at the beginning it only showed mild retrobulbar neuritis. Also the opthalmologist confirmed that the damage was very less. Still there is no chance of recovery?

Thanks and Regards,
XXXX XXXXXXX
doctor
Answered by Dr. Sudhir Kumar (2 hours later)
Brief Answer:
Recovery may occur.

Detailed Answer:
Thank you for getting back.

As mentioned, recovery may occur on its own slowly; however, the exact time frame for recovery and the amount of recovery can not be predicted.

Let us hope that she recovers.

Best wishes,

Dr Sudhir Kumar MD DM (Neurology)
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Sudhir Kumar

Neurologist

Practicing since :1994

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Suggest Treatment For Extra-pulmonary TB

Brief Answer: MRI brain shows mild ischemia Detailed Answer: Hi Mr XXXX, Thank you for posting your query. I have noted your mother's symptoms, diagnosis and past medical treatments. I have seen the MRI brain report, which is suggestive of ischemia (lack of blood supply to brain). This is most probably caused due to mild increase in blood pressure. There is no need to worry, as it can be treated with medications such as clopidogrel (to prevent further ischemia of brain). I hope my reply has helped you. I would be pleased to answer, if you have any follow up queries or if you require any further information. Best wishes, Dr Sudhir Kumar MD (Internal Medicine), DM (Neurology) XXXXXXX Consultant Neurologist Apollo Hospitals, XXXXXXX For DIRECT QUERY to me: http://bit.ly/Dr-Sudhir-kumar My blog: http://bestneurodoctor.blogspot.com/