Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
125 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction

Suggest treatment for elevated liver enzymes

Answered by
Dr. Sunil


Practicing since :1982

Answered : 351 Questions

Posted on Fri, 9 Jun 2017 in Digestion and Bowels
Question: Dr., I have been diagnosed with stetohypetitis in January 2016 (F1-F2, A1-A2). Early sign was elevated liver enzymes. Part of the problem was traced to taking 40 mg of simvastatin for cholesterol, which was more than I needed because cholesterol well under control. (Dr. raised it to 40 mg solely because it was "recommended".) After I went back to 20 mg of statin, liver enzymes returned to normal. The doctor also put me on vitamin E, 400 mg. Last fibrosure test in January 2017 showed activity stage down to A0-A1. I praise the Lord for that. Two questions: Is there a chance that the progression of this liver problem can be reversed? Also, I was prescribed omeprazole 40 mg for acid reflux, but side effects literature says, "very bad pancreas, liver and white blood cell problems have happened in people taking this medication." Also, online website raises caution in using omeprazole for people with "liver disease". Will omeperzale make my liver condition worse (raise liver enzymes, fibrosure results, etc.)? Would substituting omeperzale with ranitidine be better? Please advise and many thanks. --XXXX
Answered by Dr. Sunil 2 hours later
Brief Answer:
Proton pump inhibitor is one of the safest class of drugs.

Detailed Answer:
Thanks for posting the query on this forum.

As per your concerns answers are-

1) Statin-induced hepatotoxicity is fully reversible and all the liver enzymes should return back to normal within 6-8 weeks.

2) Theoretically cases of acute liver failure due to proton pump inhibitors have been described, but they are exceedingly rare.Proton pump inhibitor is one of the safest medicines used ever. Don't worry, too much googling can only cause unnecessary worries. Hepatotoxic effect of proton pump inhibitor is something very very rarely encountered in clinical practice.

Ranitidine is an H2 blocker but effectivity in treating Reflux of acid is far less as compared to omeprazole, Frankly speaking, I don't think omeprazole 40 mg once daily is going to do any harm to you. However, in case you want to follow the theory, you can switch over to Ranitidine 150 mg twice a day. It's safer but less effective compared to proton pump inhibitors.

Follow ups are most welcome.
Warm Regards.

Above answer was peer-reviewed by : Dr. Arnab Banerjee

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,  
Drug/Medication ,   ,  
Medical Topics ,   ,  

Recent questions on  Simvastatin

doctor1 MD

Was on Simvastatin (high cholesterol) and read in AARP that it is a statin and causes symptoms that I have had since taking it and they are...

doctor1 MD

I am experiencing some hair loss on my legs and arms, which I think may be due to Metoprolol. I don t want to loose my hair over b.p. medicine. Any...

doctor1 MD

My husband takes metropolol 300 mgs a day as well as minoxodil 20 mg per day. He also takes simvastatin 20 mg and hydrochlorothiAzide 25 mg and an...

doctor1 MD

hi, this week my doc started me on 40mg lisinopril a day added to my 25mg hydrochlorothyazide. he also started me on 20mg zocor and raised my...

doctor1 MD

I am 75 years of age and have recovered from a small cerebellar stroke three years ago.My medication is Tamulosin 400mg, Amoldipine 10mg,...

doctor1 MD

I have been taking Clonanzepam for 6 months and would like to know how to withdraw from this drug. The other drugs I take are Omeprazole once a...

doctor1 MD

I recently saw urologist have me taking tamsulosin hcl 0.4 mg have not stated taking it has yet cause I am worried about interaction with other...