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Suggest Remedy For Short Term Memory Loss

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Posted on Mon, 12 Oct 2015
Question: Hi,
My husband has recently showed signs of short term memory loss and an inability to figure out solutions to simple problems. he is a civil engineer and so this is very unusual for him. He has recently begun biting or chewing on the tip of his tongue, first on one side of his mouth, and then the other. When questioned about it, he denies that he is doing it. Also, he has begun to have difficulty driving within a single XXXXXXX of travel, and when we point it out to him he feels it is not a big issue.
I know his mother has Parkinson's but he has not shown any signs of balance disorder or tremors in his hands or legs. He is physically fit and his blood tests are always within normal ranges with the exception of triglycerides. He has some difficulty swallowing but usually when he is in a hurry and does not chew completely. Any ideas?
doctor
Answered by Dr. Dariush Saghafi (1 hour later)
Brief Answer:
Which blood tests are normal?

Detailed Answer:
Good afternoon. My name is Dr. Saghafi and I'm a neurologist from the XXXXXXX OHIO area of the world. Greetings all the Way out in Wyoming. Certainly, cognitive dysfunction can start at any age but at 61 I feel he is a bit on the younger side of the Alzheimer's Spectrum or anything similar in terms of chronic neurodegenerative dementing illness.

When you say "blood tests" are normal...exactly WHICH blood tests are obtained. Also, does your husband smoke cigarettes, drink alcohol, or currently use any OVER THE COUNTER drugs? Does his family history have anything in it with respect to Alzheimer's disease or similar?

If you could upload a copy of his latest blood work results then, I could tell you what I thought about them. I would be very interested in knowing the latest values on him such as Vitamin B12 levels, Vitamin D levels, TSH, and FT4 levels. I'd like to know what his CBC actually is with the differential count which means I want to know what the breakdown of the different cells are in the blood. I'd also ask for an ESR and CRP just to see if anything inflammatory could be going on in the body to explain this sudden change.

How is he doing on the job itself? Have you spoken to his boss or his coworkers to see if he performing up to snuff or if he's been off center lately? Has he had an imaging study of the brain such as CT scan or MRI?

I hope these suggestions satisfactorily address your question and give some additional information you can discuss with your doctor for how to attack this problem. If so, may I ask your favor of a HIGH STAR RATING with some written feedback?

Also, if there are no other comments, may I ask you not forget to CLOSE THE QUERY on your end so the question can be transacted and archived for further reference by colleagues as necessary?

You are invited to direct more comments or inquiries to me in the future by going to my web address at:

bit.ly/drdariushsaghafi

I would be honored to answer you quickly and comprehensively.

Please keep me informed as to the outcome of your husband's situation.

The query has required a total of 11 minutes of physician specific time to read, research, and compile a return envoy to the patient.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dariush Saghafi (27 hours later)
Hello Dr. Saghafi,

Thank you for your prompt response. I am attaching the results of my husbands last blood tests, taken in February, 2015.

You asked about his habits. He has never smoked, drinks one drink a day, always a beer or a wine cooler (no hard liquor).

He had his prostrate removed 5 1/2 years ago and has had .01 or less on his PSA tests every year since.

He takes indomethacin for gout on occasion (several times a year); 40 mg of pantoprazole for acid every day, and 20 mg of simvastatin for triglycerides every day.

There is no family history of Alzheimer's but his mother does have Parkinson's which was diagnosis about 4 years ago and she has displayed memory loss. She was recently placed in a nursing home. Both of his parents are alive - his dad is 84 and his mother is 83.

My husband recently retired from his job when they offered a buy out so his leaving was not job related, but last year his boss commented in a review that his poor memory was causing him to have to ask more questions about assignments.

He has never had a CT or other brain scan.

I need to know if I am just over reacting to normal aging memory loss. He began to have difficulty remembering numbers or dates perhaps as much as two years ago, but insisted he just did not feel they were necessary to remember if he wrote them down. For the last year he has refused to learn new games, card or board games, saying they no longer interest him although we have played games as a family for decades. He does not see any changes in himself, especially no memory loss but the problem is becoming more apparent to both myself and our children. The tongue chewing also concerns me although I don't know why. He does not cause any harm to his tongue with his actions and he does not even know he is doing it.

While we live in a rural area, we do have a number of medical professionals to consult should you suggest he go to see a doctor. And if you suggest we go to see a doctor should I start with his GP or do you recommend we see a specialist?

Thank you, XXXXXXX
doctor
Answered by Dr. Dariush Saghafi (16 hours later)
Brief Answer:
So let's go through each part of your response--- Ready?

Detailed Answer:
Blood results reviewed. They do not contain all the minimal elements necessary to consider a case such as this fully worked up from a metabolic point of view. He is lacking at least the following tests:

1. Thyroids (I would do a screening TSH and an FT4- if either of those were abnormal then, I'd do a full blown assay which should be handled by an endocrinologist)

2. Vitamin B12, Vitamin D, D2, D3, Folate, ESR, CRP, cortisol levels (random is fine for our purposes right now). If Vitamin B12 levels are 350 or below then, I would get confirmatory tests of a homocysteine in serum and urine (though the urine has to be processed within 30 min. of receiving the specimen so don't let him pee until he gets to the lab itself...AND THEN, make sure the technician understands it needs to be either processed immediately or kept cool until processed). You should also get a METHYLMALONIC ACID if the B12 is low or thresh hold low.

3. Vitamin D levels (if low and they almost invariably are VERY LOW in the majority of us northerners that never sunbathe after age 6 when our parents would take us to the beaches to play!) should be a minimum of 60 if not closer to 70 or even 80. That's slightly tricky but well worth the effort to get up that high and maintain it since Vitamin D is great for all sorts of things.

4. Did he have prostate cancer? You say that his PSA is good...and that's fine....but if his mental status is becoming this deficient in the face of prostate CA then, I would definitely consider getting an imaging study of the head in the form of an MRI with gadolinium contrast. Chances are it will come out normal....but prostate CA does frequently metastasize to the brain and it can be so subtle in its presentation that nobody ever even looks for it because they're not aware of how much that sort of cancer likes going to that location and so young people (such as your husband) can have problems that others may just pass off as stress, anxiety, "getting old"....which heck....61?? I'm there in the next 6 years and I'll be GD'ed if anybody's gonna call me old because of anything that might happen physically or mentally.....horse dung on that idea......so you get him that MRI with the contrast.

5. Now, about the contrast, he'll need to get a clearance on his kidneys which has to be within 30 days of the test so the one you got with the lab tests is too old....weren't they done in like February?? What he needs for clearance is something that I believe I saw on the original set of tests which is a creatinine AND a calculated EGFR. You can get that all done with the other tests...no big deal....

6. 1 drink is not that much....but with his mental status being compromised and not knowing from what.....any little bit of alcohol could be toxic to the brain and right now he needs to be firing on all cylinders as much as possible while we get this thing figured out....so my recommendation is that he become a teetotaler for now...or at worst a wine cooler a couple times a week......You drink the rest of the stash up from here on out and tell him you've suddenly taken a liking to the high powered grape juice and he better get whatever he can while it's around cuz you're planning on puttin' some cowgirl boots on as well and headin' out to the closest XXXXXXX XXXXXXX concert comin to town! LOL!!

Seriously, as little alcohol as possible will preserve as much as possible while we figure out what's going on.

7. Pantoprazole (as well as all of its cousins...meaning anything whose name ends in an -PRAZOLE) has been strongly implicated in compromised cognition and should not be ingested if alternatives are available. I understand why he's doing it because of the indomethacin which can really tear up the stomach. However, one medication that I've found very good in my patients with gout which allows us to avoid this class of medication is CYTOTEC. It's a bit pricey and some insurance plans don't cover it if he tolerates the lower scaled antacid medications. But that's my advice if we want to try and cut out any and all things that could be interfering with his brain's function at this point.

8. 61 is way too young for him to be suffering from Alzheimer's Disease (AD) in my opinion. I understand that there may be a family history in the mother who also has Parkinson's Disease (PD) and probable dementia associated with the PD....actually, the current thinking is that when patients with PD develop it probably ends up being AD. Still he is about 20 years ahead of his predicted time if she in fact, has AD. So, I would definitely be focused on something metabolic going on as well as the prostate issue if in fact, it was a cancer he had removed.

9. As far as getting him off the couch to do active things....I wish I had the magic answer...I don't....send him back to work would be the best thing but I also heard you when you said that even being on the job ended up getting him asked to leave because he was starting to flounder and it affected his work....again, a very good reason to think that this is NOT TYPICAL run of the mill aging or unlucky AD....something else is pushing him down the tracks at a faster pace than usual. But clearly, both PHYSICAL AND MENTAL ACTIVITIES are his best hedges against further decline and even a little bit of a turn around. You need to find a creative way to get him interested again in games, sports, family get togethers, maybe building you a few new cabinets....just don't let him use power tools! OUCH!

10. I saw you mentioned CT...forget the CT in his case. I would go for the MRI with gadolinium contrast and make sure the radiologist knows he has a history of early cognitive demise and prostate (cancer?) issues. Is he still taking the medicine for the prostate problem whatever it was? Some of that stuff can make people goofy upstairs as well...don't know if that has anything to do with it...but I'd track it down if he's still taking anything.

11. Clearly his triglycerides were way up and that's a risk factor for vascular disease of the brain. On the other hand simvastatin is not that great for the brain either from a chemical point of view.

12. Again, I underscore how far away I want you to run from the phrase, "normal aging memory loss..." You say he was having problems as far back as 2 years ago which probably goes farther back than that since he noticed it but just probably didn't say anything to you until you noticed it....so even if we want to assume he was 58 or 59 when he started having trouble and began developing apathy/denial whatever you want to call it....that is not part of the normal aging process in a person still in their 6 decade of life (No- I did not miswrite....at age 58 he was in his SIXTH decade of life...you'll see it when you do the math! HA!).

13. I would definitely seek out a neurologist and couple that up with a neuropsychologist would I would utilize if he were here with me as his doctor.....in fact, let me just throw out this crazy idea.....I-80 runs right through XXXXXXX OH.....and we'll just leave it at that! HAHA! Hey, nothing like spiking up an interest by taking a road trip out East, don't you think? LOL!

I hope these suggestions satisfactorily address your questions and give some additional information you can discuss with your NEUROLOGY DOCTOR regarding the concerns you have. If so, may I ask your favor of a HIGH STAR RATING with some written feedback?

Also, if there are no other comments, may I ask you not forget to CLOSE THE QUERY on your end so the question can be transacted and archived for further reference by colleagues as necessary?

You are invited to direct more comments or inquiries to me in the future by going to my web address at:

bit.ly/drdariushsaghafi

I would be honored to answer you quickly and comprehensively.

Please keep me informed as to the outcome of your situation.

The query has required a total of 85 minutes of physician specific time to read, research, and compile a return envoy to the patient.


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dariush Saghafi (48 hours later)
Thank you so very much for your time and the detail you put into answering my question. I intend to schedule an appointment with a neurologist to follow up on all you have suggested. I also appreciate your humor in responding to my question. You obviously picked up on my dark mood and you took the time to set me at ease as well as set me on a path that includes some much more positive alternatives than just AD and PD.

I was wondering what medical institute you practice at in Cleveland? I was unable to get through on the web address you provided. We do travel to the east coast once or twice a year and who knows, we may meet yet!

Thank you again and I will be closing the query and leaving my comments.
doctor
Answered by Dr. Dariush Saghafi (4 hours later)
Brief Answer:
Parma neurology (On Facebook)

Detailed Answer:
Your comments are too kind....I am Chief Neurologist of Parma Neurology which is my own proprietary practice and I also work at the XXXXXXX Stokes VA Hospital and run their Headache Division as well as do Medical Educational Programming for the physicians and a few other things.

The VA is right down the street from some terrific places that you'd enjoy touring:

1. Severance Hall- Home of the world renowned XXXXXXX Orchestra
2. Progressive Field- Home of the XXXXXXX Indians (are we still mathematically in it?)
3. First Energy Field- Home of the XXXXXXX Browns (still looking for that SuperBowl Ring...and probably won't find it in my lifetime..... :( )
4. The Great Lakes Science Museum (Next to the Rock 'n Roll Hall of Fame)
5. And then, there's this great little Starbuck's right in the heart of the campus of Case Western Reserve University....with the dubious fame of having a CharterOne Bank inside there with it which has been robbed twice during daylight hours by thieves who first stopped at the Starbucks counter to BUY...THEY BOUGHT their coffees...sat down at the tables chit chatting with each other and then, proceeded to XXXXXXX the Charterone Bank on the other side of the lobby!!! What the heck was in that coffee?? LOL......

And I love that place...go to it all the time....I'm always watching for people now in ski masks having coffee and talking with each other so I get ready my iphone camera....get it on YouTube and make a million!! HAHA!

Hope all goes well and yes, I would be honored to meet up with you and your husband if you do come out this way....gut impression tells me that there's at least an even chance he's got something fixable due to his age and the fact that this all started when he was in his 50's....really shouldn't be Alzheimer's.....I'm crossing fingers that the MRI can come out clean....

Keep me apprised of what you find out.....

My address on this network is: bit.ly/drdariushsaghafi

Cheers!
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Dariush Saghafi

Neurologist

Practicing since :1988

Answered : 2473 Questions

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Suggest Remedy For Short Term Memory Loss

Brief Answer: Which blood tests are normal? Detailed Answer: Good afternoon. My name is Dr. Saghafi and I'm a neurologist from the XXXXXXX OHIO area of the world. Greetings all the Way out in Wyoming. Certainly, cognitive dysfunction can start at any age but at 61 I feel he is a bit on the younger side of the Alzheimer's Spectrum or anything similar in terms of chronic neurodegenerative dementing illness. When you say "blood tests" are normal...exactly WHICH blood tests are obtained. Also, does your husband smoke cigarettes, drink alcohol, or currently use any OVER THE COUNTER drugs? Does his family history have anything in it with respect to Alzheimer's disease or similar? If you could upload a copy of his latest blood work results then, I could tell you what I thought about them. I would be very interested in knowing the latest values on him such as Vitamin B12 levels, Vitamin D levels, TSH, and FT4 levels. I'd like to know what his CBC actually is with the differential count which means I want to know what the breakdown of the different cells are in the blood. I'd also ask for an ESR and CRP just to see if anything inflammatory could be going on in the body to explain this sudden change. How is he doing on the job itself? Have you spoken to his boss or his coworkers to see if he performing up to snuff or if he's been off center lately? Has he had an imaging study of the brain such as CT scan or MRI? I hope these suggestions satisfactorily address your question and give some additional information you can discuss with your doctor for how to attack this problem. If so, may I ask your favor of a HIGH STAR RATING with some written feedback? Also, if there are no other comments, may I ask you not forget to CLOSE THE QUERY on your end so the question can be transacted and archived for further reference by colleagues as necessary? You are invited to direct more comments or inquiries to me in the future by going to my web address at: bit.ly/drdariushsaghafi I would be honored to answer you quickly and comprehensively. Please keep me informed as to the outcome of your husband's situation. The query has required a total of 11 minutes of physician specific time to read, research, and compile a return envoy to the patient.