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Suggest dosage for Oxycodone while on Morphine Sulfate

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Posted on Wed, 6 Jan 2016
Question: If I am taking 60mg of Morphine Sulfate (immediate release) 3 times a day, what would be the equivalent dose of Oxycodone?
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Answered by Dr. Matt Wachsman (29 minutes later)
Brief Answer:
not as straightforward as it sounds!

Detailed Answer:
There are all these tables on this topic. and they mainly give the same answer. (by the way, I have to mention that 180 mg of morphine is considered a high dose and statistically associates with an increased risk of complications).

The equivalent oxycodone is less, maybe 20 mg per 30 mg of morphine
XXXX

BUT !
It turns out that reality trumps charts that do not give their basis for their calculations! There are a lot of genetically based differences on how people handle and react to different narcotics. Individual results on this vary tremendously. Furthermore of a given dose of a given drug, while the FDA closely regulates how much gets in the pill and how much gets into the person, there is no regulation on how fast that amount gets in then wears off (how tightly the pill is packed together).

You can get an estimate; it will be wrong.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Matt Wachsman

Addiction Medicine Specialist

Practicing since :1985

Answered : 3703 Questions

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Suggest dosage for Oxycodone while on Morphine Sulfate

Brief Answer: not as straightforward as it sounds! Detailed Answer: There are all these tables on this topic. and they mainly give the same answer. (by the way, I have to mention that 180 mg of morphine is considered a high dose and statistically associates with an increased risk of complications). The equivalent oxycodone is less, maybe 20 mg per 30 mg of morphine XXXX BUT ! It turns out that reality trumps charts that do not give their basis for their calculations! There are a lot of genetically based differences on how people handle and react to different narcotics. Individual results on this vary tremendously. Furthermore of a given dose of a given drug, while the FDA closely regulates how much gets in the pill and how much gets into the person, there is no regulation on how fast that amount gets in then wears off (how tightly the pill is packed together). You can get an estimate; it will be wrong.