• question-icon

    Suggest dosage for Allopurinol

Posted on Wed, 2 Aug 2017 in Lupus
Question: Hello - I have been taking 100 mg of allopurinol for a year to manage attacks of the gout. I increased the does to 200 mg for a week to see if this would help. I have reduced kidney function with a GFR of 69 as a result of a silent kidney stone that caused a blockage I was not aware of . No symptoms. Other kidney is normal and healthy. After a week, I stopped taking the higher dose of Allopurinol for fear that the higher dose might damage my kidney function. I am back to the usual 100 mg. dose. I get all panicked about my kidney function - some might say obsessively so. I am a male - 64 years of age. I have had 2 recent gout attacks - one that was aided with a cortisone shot however the current attack has been ongoing for 6 plus weeks now. Dr. prescribed various meds with no success. Also had a cortisone shot which assisted in reducing the pain however my toe is still swollen although less so now. I apologize for the length of my question.I had my uric acid tested as well as various blood tests. Results came back and my uric acid is 300. Why I was concerned about my GFR is that is has been rising over the past year from around the 56 - 58 mark 82, then 88 and then 92. As indicated, the test results that just came back pegged it at 69. That is when I thought I might have damaged my kidneys ( the damaged kidney still has very limited function ) by taking the increased dose of Allopurinol ( 200 mg ) for a week before stopping and reverting back to 100 mg. My GP has been out of the country for 6 weeks so I am dealing with a locum.
Answered by Dr. Divya Agarwal 1 hour later
Brief Answer:
Don't worry it is a small dose

Detailed Answer:
This is a small dose.
This drug Will not impair renal function however there may be side effects in people who have impaired renal function.
So I suggest that Keep the drug at the same level especially since you are suffering an acute attack presently.
There is another drug called febuxostat which is slightly safer in people with impaired renal function
This can be considered.
An anti inflammatory like cortisone or colchicine should also be considered for your acute attack.
Above answer was peer-reviewed by : Dr. Remy Koshy
Answered by
Dr. Divya Agarwal


Practicing since :1999

Answered : 616 Questions


The User accepted the expert's answer

Share on

Recent questions on  Febuxostat

doctor1 MD

I started taking allopurinol 4 days ago 100mg daily for high uric acid levels. Have had gout on & off for years but this flare-up has been the...

doctor1 MD

Yes, I have was taking 100 mg of allopurinol and 0.6 colcrys to control my uric acid. When I saw the dr 2 weeks ago my uric acid was even higher....

doctor1 MD

I have pain in my coccyx .i consultted a orthologist,he identified it as increase in uric acid(8.0).and avdice to take febuxostat 40mg.but after 15...

doctor1 MD


doctor1 MD

Since November 1 I have had an inflammation in the large toe of my right foot and my doctor said it was gout . I have had gout in the past but...

doctor1 MD

I have constant foot pain. The pain moves from one foot to another - literally. The most recent was heal pain - the back of my heal, not the...

Get personalised answers from verified doctor in minutes across 80+ specialties

158 Doctors Online

By proceeding, I accept the Terms and Conditions

HCM Blog Instant Access to Doctors
HCM Blog Questions Answered
HCM Blog Satisfaction
Questions Answered By Dr. Divya Agarwal
  • Q - How common is for a person in 60s or 70s of developing rheumatoid...

  • Q - Having severe abdominal pain. Tested negative for rheumatoid arthritis...

  • Q - Taking folitrax 7.5 mg. Having joint pains. Is rheumatoid arthritis...

  • Q - Have wrist pain, negative for rheumatoid factor. Had ITP and...

  • Q - Getting tingling fingers, nodule at knuckle. What is the difference...

  • Q - Tiredness, headache, taking depression medication. Any suggestions?

  • Q - 84 year old having severe arthritis. On morphine patches. How to improve...

  • Q - Fall on buttocks. Suffering from back pain. Diagnosed with si joint...

  • Q - Tested HLA B27 positive. Feeling fatigued, sensitive back and buttocks....

  • Q - Thumb is very sore at the base and noticed swollen blood vessels. How to...