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Dr. Andrew Rynne

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Suggest alternate medicine for Pregabalin in treating neuropathic pain in cancer patients

Answered by
Dr. Dariush Saghafi


Practicing since :1988

Answered : 2034 Questions

Posted on Mon, 19 Oct 2015 in Brain and Spine
Question: Hi,
What pain relief medications are suitable as an adjunct to pregabalin spinal cancer?
Answered by Dr. Dariush Saghafi 51 minutes later
Brief Answer:
Breakthrough Cancer pain is VERY CHALLENGING to treat

Detailed Answer:
Very sorry to hear that your BIL is suffering from metastatic bony lesions. In oncology this is one of the most challenging and difficult forms of Cancer Pain to adequately treat. Breakthroughs are constantly occurring and often do not really involve specific triggers, etc.

Here is a list of commonly employed drugs for this type of pain. You will want to ask either the surgeon or anesthesiologist opinions directly from them as to their preferences for breakthrough pain.

1. sublingual ketamine (high potential for addiction)
2. High dose and frequent corticosteroid infusions either manually or by your symptoms.
3. Levobupivicaine (anesthetic)
4. Xgeva (preventative used in conjunction with PAIN MEDICATIONS in order to avoid bone fractures and compressions which can escalate pain level).
5. Oxcarbazepine, Phenytoin, Carbamazepine, Nortriptyline, Amitriptyline, Lamotrigine, and Topiramate

Best of luck.

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