Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

186 Doctors Online
Doctor Image
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

Pregnant. Blood test showed low MCV and MCH level. Chances of child having thalassemia?

Answered by
Dr. Das Arindam

General & Family Physician

Practicing since :2008

Answered : 1416 Questions

Posted on Tue, 22 Jan 2013 in Pregnancy
Question: Hi ,
I am XXXXXXX from New Delhi. My wife is 3 weeks pregnant. Today an utrasound was carried out and it was told by our doctor that every thing is ok. Also doctors has seen the hemoglobin test report. The test report findings are HB F is 26.90% ( SHOULD BE <1.50) , HB A2 is 2.20 ( SHOULD BE BETWEEN 1.50 TO 3.00), and Hemoglobin is 12 g/dL. doctors looks bit worried after seeing the report and asked me to go for Hemoglobin HPCL test. is there any chance that our child may suffer from thalaseemia!!!
Answered by Dr. Das Arindam 32 minutes later
Thank you for posting a query.

After seeing the reports, I have found that the MCV and MCH are lower than normal value. It may be due to the iron deficiency that usually occurs at this stage of pregnancy. Consult with your treating doctor about it.

Now, the Hemoglobin report.

In thalassemia carrier state, the HbA2 level should be more than 4%. Your wife’s HbA2 is below that range. So, thalassemia carrier state is not possible.

In some individual, HbF level may be high idiopathically. That means, no definite disease condition is present. But persistently high level of fetal hemoglobin is detected.

In this situation we generally advice to repeat the HPLC test from another laboratory. If that report also becomes inconclusive, then we generally advice to do a parental study. That means HPLC study of the parents of your wife to rule out possibility of any mild abnormality in hemoglobin.

lastly, it is mandatory to do a HPLC test of both husband and wife at this stage. Because, thalassemia is a genetic disease. If any one of you has any abnormality that has a chance to get transmitted in your baby.

So, without your HPLC report, it is not possible to comment whether you child may suffer from thalassemia or not.

Hope this information suffices. Let me know, if you have any more question.


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,   ,   ,  
Medical Topics ,   ,  

Recent questions on  Hemoglobin

doctor1 MD

My age is 40,weight is 76kgs and height is 5 feet and 11 inches. My heartbeat is 82 and blood pressure is 130/80. When ever I try to exercise, after someday my blood pressure becomes high and I feel problem in breathing. I did lung x-ray and it shows o.kay. I tested my lipid profile and hemoglobin test and eeg[color doppler] test. Av is slightly enlarged. In lipid profile triglyceride is 345 and cholesterol is 240. I checked my diet and took medicines. The problem is less but not totally cured.

doctor1 MD

I have been running a fever and having bodyache since i started prednisone, I finished prednisone last friday for poison oak and the poison oak cleared however bodyache/headache and fever are persisting. my doctor ordered several blood tests to try to find out whats going on and found my hgb elevated and my lfts elevated....she cannot explain to me what is going on and is blaming the high hgb on smoking...?

doctor1 MD

My 2 year old son has a hemoglobin level of 9.1 and his platelet count is high but not sure of number. Something in his urine also showed an issue with his kidneys. The past 2-3 weeks he has had very excessive thirst and urinating very frequently. Pcp has referred him to a pediatric nephrologist. Is there anything I can do to help him before this appointment. Also how soon should he be seen if the appointment isn't very soon?

doctor1 MD

The right lower limb is noticeably shorter than the left. The right limb is externally rotated, and the patient is unable to change the limb s position without considerable pain. On palpation, the groin region is tender, but no swelling is obvious. Passive movement of the hip causes extreme pain, especially upon external and internal rotation. WBC is 20 Hemoglobin (Hgb) is 9.8 what is is?

doctor1 MD

A co-worker was fine one minute..then suddenly said she didn't feel well. Moments later, she passed out for a minute or two. We shook her awake and she simultaneously vomited blood clots and spoiled her pants. She turned completely white - almost...

doctor1 MD

Do you think at ESA therapy is a good option for a 90 yo male with CKD stage 3A? RBC count is 2.91; HGB 9.9; HCT 29.1; platelet count 104; GFR est non-AA 58; Micralb/Crea ratio (ug/mg creat) 59.0; Pt is always cold , extremely fatigued-sleeps 15...

doctor1 MD

Hi doctor My age is 32 years and weight 55kg, from last 3-4 months im feeling so much of weekness and always feel like sleeping. Even if i sleep early i dont feel like getting up early in the morning. Im usually a hard working women stretch...