Question: My daughter (18 years old ) has been on a very low dose of Aygestin (2.5mg=one half of the lowest dose pill available) for about a year and a half to stop periods because of endometriosis discovered during an appendectomy. She has also been diagnosed with autonomic dysfunction and is suspected to have Ehlers Danlos Syndrome (Type 3 hypermobility). She was put on the progesterone type pill because of a history of migraines. She has started having depression and anxiety and is on zoloft (50mg) which has helped her dad and brother (who also has autonomic dysfunction). She expresses "upset and sadness" which seems to relieve a little and then return. She has started college, which has added to the stress, but this goes way beyond the normal homesick and/or school stress. Is it possible that her body is fighting the low dose aygestin (trying to break through), or that the aygestin is causing any of this...or any other ideas. She also has persistent GI issues which they now think are part of the big picture (autonomic as opposed to strictly GI). Any thoughts for this great kid. She's working hard and doing well in school, but really suffering.
She had RSD (reflex sympathetic dystrophy) in the past after a misdiagnosed ankle fracture. Her current symptoms include, in addition to GI ("visceral hyperalgesia" now thought to be related to the autonomic issues), Depression and anxiety, coldness, fatigue.....
She has had thyroid tests (normal), blood counts (normal), GI scopes (largely normal) autonomic testing (dysfunctional) and a variety of tests in the past.
She is very aware of her issues and has always worked hard to push through and remain active and successful. This increase in the "upset" feelings is very difficult. She thinks that she has had some "sadness" or disinterest in things for a year or two, but has noticed a great increase in the last few months (a couple of months before starting school). She is very aware of the "upset" that seems unrelated to particular events..... She was out with me yesterday and said that Sunday had been a little better than Saturday (felt like crying, but persisted with activities), but then suddenly felt the upset come on out of the blue.

I know that depression...is a listed side effect. She is on an extremely low dose. I had asked about any possible effects of the low dose-such possibility of her period trying to break through leading to a persistent sort of PMS state.
The aygestin is prescibed to eliminate periods to reduce damage and scar tissue from monthly shedding of the endometrial tissue, not necessarily for symptoms.
I also stated that her GI and other symptoms are thought to be autonomic.
I was just looking for some insight into the interplay of these problems and any possible hormonal effects, or suggestions on the depression type feelings. Your response gave me no new information. I know that this a complex problem, I was just hoping to happen to hit someone who might have some incidental experience that could come to bear.