Need opinion on treatment course for my wife for invasive
PR: Positive (70% of tumour cells show nuclear staining with strong intensity, Allred score 8/8).
HER2/neu (Ventana): Positive (Score 3+)
Total mastectomy is needed.
Thanks for posting your query.
I have gone through your query and understand your health concerns.
An invasive carcinoma of breast Grade III with ER and PR positive needs a radical mastectomy. Only lumpectomy is associated with very high chances of recurrence and the five year survival decreases considerably due to recurrence. Whole breast along with regional lymph nodes need to be removed to prevent further spread of the disease. Chemotherapy only restricts the tumor growth for a short period of time.
I hope this answers your query.
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Wishing you good health.
Dr. Rakhi Tayal