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My HBa2 Is 5.8 ( Beta-thalassemia Trait ) And My

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Posted on Sun, 26 Jul 2020
Question: My HBa2 is 5.8 (Beta-thalassemia trait) and my husband HBa2 is 4....we have daughter whose HBa2 is 3.6 (Delta Beta Thalassaemia Trait.)... we dont have any issues still now....we are planning for 2 nd...plz suggest for any test is required or how much safety is there.
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Answered by Dr. Shailja Puri (28 hours later)
Brief Answer:
Molecular testing to detect Hb mutation for your family is suggested

Detailed Answer:
Hello,
Thanks for posting your query on Ask A Doctor forum.
The haemoglobin electrophoresis reports give a clear picture that you and your husband have elevated HbA2 which is suggestive of thalassemia trait.
These results should be followed by molecular tests for detecting mutations in haemoglobin chain.
You have had a one year old child with 20% fetal haemoglobin which is high as compared to normal range for age.
In addition, there is elevated level of HbA2 also.
Your child also needs to undergo molecular test.
I would suggest you to get the molecular test done before planning second pregnancy.
In addition, subsequent pregnancies should be tested for any mutation during pre-natal period.
Since, both you and your husband have thalassemia trait, precautions in the form of counselling and pre-natal testing should be done to avoid any pregnancy with thalassemia major or intermedia.

Thanks and take care
Dr Shailja Puri

Above answer was peer-reviewed by : Dr. Raju A.T
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Answered by
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Dr. Shailja Puri

Pathologist and Microbiologist

Practicing since :2006

Answered : 8332 Questions

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My HBa2 Is 5.8 ( Beta-thalassemia Trait ) And My

Brief Answer: Molecular testing to detect Hb mutation for your family is suggested Detailed Answer: Hello, Thanks for posting your query on Ask A Doctor forum. The haemoglobin electrophoresis reports give a clear picture that you and your husband have elevated HbA2 which is suggestive of thalassemia trait. These results should be followed by molecular tests for detecting mutations in haemoglobin chain. You have had a one year old child with 20% fetal haemoglobin which is high as compared to normal range for age. In addition, there is elevated level of HbA2 also. Your child also needs to undergo molecular test. I would suggest you to get the molecular test done before planning second pregnancy. In addition, subsequent pregnancies should be tested for any mutation during pre-natal period. Since, both you and your husband have thalassemia trait, precautions in the form of counselling and pre-natal testing should be done to avoid any pregnancy with thalassemia major or intermedia. Thanks and take care Dr Shailja Puri