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Is There Interaction Between Metoprolol Tartrate And Uroxatrol?
Question: I just started taking metoprolol tartrate mg 25 but I also take uroxatrol and I see there may be an interaction. I have taken 1 metoprolol and I felt weird and weak as well as nauseated but it is better. should I continue and see what happens or call the doctor Monday and not take more?
Brief Answer:
Should not be combined
Detailed Answer:
Hello. Thank you for your question and welcome to Health Care Magic. I understand your concern.
Metoprolol, a beta-blocker, has a moderate risk to be combined with alfuzosine or tamsulosine, alpha agonists. This is mainly because the inhibition of the beta-blockade, caused by beta-blockers, and stimulation of alpha-adrenergic receptors, can promote the alpha route and, therefore, over express the alpha-adrenergic actions. The most important one is over constriction of the smooth muscle of various arteries.
I would recommend you to discontinue metoprolol, since uroxatral is necessary for your benign hypertrophy of the prostate. If metoprolol is taken for blood pressure-lowering aim, then an angiotensinogen converting enzyme inhibitor (ACE-I) can be taken instead. I would recommend ramipril. I recommend you to discuss with your cardiologist about the dosage and frequency of taking. It should be 5 mg and divided in to halves. Even though a combination of a beta-blocker with alpha-agonist carries only moderate risk, as I mentioned above, my advice would be not to "mix" them together, because of the direct opposing effects they possess.
I hope I was helpful with my answer. If you have follow-up questions, I am happy to help. Please rate the answer, if you do not. Wish you a good health.
Best regards,
Dr. Meriton
Should not be combined
Detailed Answer:
Hello. Thank you for your question and welcome to Health Care Magic. I understand your concern.
Metoprolol, a beta-blocker, has a moderate risk to be combined with alfuzosine or tamsulosine, alpha agonists. This is mainly because the inhibition of the beta-blockade, caused by beta-blockers, and stimulation of alpha-adrenergic receptors, can promote the alpha route and, therefore, over express the alpha-adrenergic actions. The most important one is over constriction of the smooth muscle of various arteries.
I would recommend you to discontinue metoprolol, since uroxatral is necessary for your benign hypertrophy of the prostate. If metoprolol is taken for blood pressure-lowering aim, then an angiotensinogen converting enzyme inhibitor (ACE-I) can be taken instead. I would recommend ramipril. I recommend you to discuss with your cardiologist about the dosage and frequency of taking. It should be 5 mg and divided in to halves. Even though a combination of a beta-blocker with alpha-agonist carries only moderate risk, as I mentioned above, my advice would be not to "mix" them together, because of the direct opposing effects they possess.
I hope I was helpful with my answer. If you have follow-up questions, I am happy to help. Please rate the answer, if you do not. Wish you a good health.
Best regards,
Dr. Meriton
Note: For further queries related to coronary artery disease and prevention, click here.
Above answer was peer-reviewed by :
Dr. Arnab Banerjee
Answered by
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